Acetylcholinesterase

Description:

Description
  • Accession: P21836
  • Swissprot: ACES_MOUSE
  • Organism: Mus musculus
  • Gene: Ache
  • Target class: Enzyme

Drug Relations:

ambenonium
A quaternary ammonium compound that is an inhibitor of cholinesterase activity with actions similar to those of NEOSTIGMINE, but of longer duration. Ambenonium is given by mouth in the treatment of myasthenia gravis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1112) Bioactivity details MOA
atropine
An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE. Hyoscyamine is the 3(S)-endo isomer of atropine. Bioactivity details MOA
carbachol
A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS. Bioactivity details MOA
decamethonium
Bioactivity details MOA
donepezil
FDA approved for the treatment of mild to moderate dementia of the Alzheimer type; structure given in first source; RN given refers to HCl; RN for parent cpd not avail 10/92 Bioactivity details MOA
galantamine
A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders. Bioactivity details MOA
meptazinol
A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain. Bioactivity details MOA
paraoxon
An organophosphate cholinesterase inhibitor that is used as a pesticide. Bioactivity details MOA
physostigmine
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. Bioactivity details MOA
rivastigmine
A carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON DISEASE. Bioactivity details MOA
suxamethonium
A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. Bioactivity details MOA
tacrine
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Bioactivity details MOA
velnacrine
Bioactivity details MOA