Aromatic-L-amino-acid decarboxylase


  • Accession: P20711
  • Swissprot: DDC_HUMAN
  • Organism: Homo sapiens
  • Gene: DDC
  • Target class: Enzyme

Drug Relations:

An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no antiparkinson actions by itself. Bioactivity details MOA
An inhibitor of DOPA DECARBOXYLASE that does not enter the central nervous system. It is often given with LEVODOPA in the treatment of parkinsonism to prevent the conversion of levodopa to dopamine in the periphery, thereby increasing the amount that reaches the central nervous system and reducing the required dose. It has no antiparkinson actions when given alone. Bioactivity details MOA
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent. Bioactivity details MOA