Dihydrofolate reductase

Description:

Description
  • Accession: P16184
  • Swissprot: DYR_PNECA
  • Organism: Pneumocystis carinii
  • Target class: Enzyme

Drug Relations:

trimetrexate
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect. Bioactivity details MOA
brodimoprim
inhibits dihydrofolate reductase Bioactivity details MOA
cycloguanil
was MH 1975-92 (see under TRIAZINES 1975-90); use CYCLOGUANIL EMBONATE was see CYCLOGUANIL PAMOATE 1975-92; TRIAZINES to search CYCLOGUANIL PAMOATE 1975-92; metabolite of chloroguanide Bioactivity details MOA
dapsone
A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Bioactivity details MOA
iclaprim
has antiviral activity Bioactivity details MOA
methotrexate
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Bioactivity details MOA
pyrimethamine
One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. Bioactivity details MOA
sulfamethoxazole
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208) Bioactivity details MOA
trimethoprim
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. Bioactivity details MOA