Atrial natriuretic peptide receptor 1


  • Accession: P16066
  • Swissprot: ANPRA_HUMAN
  • Organism: Homo sapiens
  • Gene: NPR1
  • Target class: Enzyme

Drug Relations:

Bioactivity details MOA
glyceryl trinitrate
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives. Bioactivity details MOA
isosorbide dinitrate
A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. Bioactivity details MOA
isosorbide mononitrate
for prevention of angina pectoris; structure given in first source; a Russian drug Bioactivity details MOA
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase. Bioactivity details MOA
Sodium nitroprusside interacts with oxyhemoglobin to produce methemoglobin, cyanide, and nitric oxide (NO). NO then reacts with guanylate cyclase in vascular smooth muscle to produce cGMP that reduces intracellular calcium concentrations resulting in relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Bioactivity details MOA