Integrin alpha-IIb

Description:

Description
  • Accession: P08514
  • Swissprot: ITA2B_HUMAN
  • Organism: Homo sapiens
  • Gene: ITGA2B
  • Target class: Adhesion

Drug Relations:

abciximab
a monoclonal antibody Fab fragment that blocks the platelet glycoprotein IIb/IIIa receptor & potently inhibits platelet aggregation; used in treatment of refractory unstable angina Bioactivity details MOA
eptifibatide
used in clinical studies as a platelet glycoprotein IIB/IIIA antagonist Bioactivity details MOA
tirofiban
a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor, the major platelet surface receptor involved in platelet aggregation, when administered intravenously inhibits ex vivo platelet aggregation in a dose- and concentration-dependent manner Bioactivity details MOA