Glucocorticoid receptor

Description:

Description
  • Accession: P06536
  • Swissprot: GCR_RAT
  • Organism: Rattus norvegicus
  • Gene: Nr3c1
  • Target class: Transcription factor

Drug Relations:

androstanolone
A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE. Bioactivity details MOA
beclometasone dipropionate
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA. Bioactivity details MOA
betamethasone dipropionate
Bioactivity details MOA
budesonide
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS. Bioactivity details MOA
clobetasol propionate
A derivative of PREDNISOLONE with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than FLUOCINONIDE, it is used topically in treatment of PSORIASIS but may cause marked adrenocortical suppression. Bioactivity details MOA
dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid. Bioactivity details MOA
dexamethasone palmitate
a liposteroid for treatment of hemophagocytic lymphohistiocytosis Bioactivity details MOA
dexamethasone phosphate
Bioactivity details MOA
dexamethasone valerate
Bioactivity details MOA
fluticasone furoate
Fluticasone furoate is a synthetic trifluorinated corticosteroid with anti‑inflammatory activity. Fluticasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor. The precise mechanism of corticosteroid action on asthma is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of actions on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, cytokines) involved in inflammation. These anti-inflammatory actions of corticosteroids contribute to their efficacy in asthma. Bioactivity details MOA
fluticasone propionate
A STEROID with GLUCOCORTICOID RECEPTOR activity that is used to manage the symptoms of ASTHMA; ALLERGIC RHINITIS, and ATOPIC DERMATITIS. Bioactivity details MOA
mifepristone
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME. Bioactivity details MOA