Neuraminidase

Description:

Description
  • Accession: P03474
  • Swissprot: NRAM_INBLE
  • Organism: Influenza B virus (strain B/Lee/1940)
  • Gene: NA
  • Target class: Enzyme

Drug Relations:

oseltamivir
Oseltamivir phosphate is an ethyl ester prodrug requiring ester hydrolysis for conversion to the active form, oseltamivir carboxylate. Oseltamivir carboxylate is an inhibitor of influenza virus neuraminidase affecting release of viral particles. The median IC50 values of oseltamivir against influenza A/H1N1, influenza A/H3N2, and influenza B clinical isolates were 2.5 nM (range 0.93-4.16 nM, N=74), 0.96 nM (range 0.13 - 7.95 nM, N=774), and 60 nM (20-285 nM, N=256), respectively, in a neuraminidase assay with a fluorescently labeled MUNANA substrate. Bioactivity details MOA
peramivir
Peramivir is an inhibitor of influenza virus neuraminidase, an enzyme that releases viral particles from the plasma membrane of infected cells. Bioactivity details MOA
zanamivir
A guanido-neuraminic acid that is used to inhibit NEURAMINIDASE. Bioactivity details MOA