Transthyretin

Description:

Description
  • Accession: P02766
  • Swissprot: TTHY_HUMAN
  • Organism: Homo sapiens
  • Gene: TTR
  • Target class: Secreted

Drug Relations:

tafamidis
may be effective in treating transthyretin amyloid polyneuropathy Bioactivity details MOA
aceclofenac
Bioactivity details MOA
diclofenac
A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt. Bioactivity details MOA
diflunisal
A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of ASPIRIN. Bioactivity details MOA
flufenamic acid
An anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically. (From Martindale, The Extra Pharmacopoeia, 30th ed, p16) Bioactivity details MOA
gemfibrozil
A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. Bioactivity details MOA
levothyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. Bioactivity details MOA
masoprocol
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. Bioactivity details MOA
meclofenamic acid
A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. Bioactivity details MOA
nifedipine
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure. Bioactivity details MOA
niflumic acid
An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. Bioactivity details MOA
nitrendipine
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive. Bioactivity details MOA
tolfenamic acid
Bioactivity details MOA