Proto-oncogene tyrosine-protein kinase Src
Description:
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Drug Relations:
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dasatinib
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A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB. | Bioactivity details | MOA |
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imatinib
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A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors. | Bioactivity details | MOA |
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ponatinib
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a pan-Bcr-Abl protein kinase Inhibitor | Bioactivity details | MOA |
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sunitinib
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inhibits VEGF-R2 and PDGF-Rbeta tyrosine kinase; has antineoplastic activity | Bioactivity details | MOA |
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