Dihydrofolate reductase type 1


  • Accession: P00382
  • Swissprot: DYR1_ECOLX
  • Organism: Escherichia coli
  • Gene: dhfrI
  • Target class: Unclassified

Drug Relations:

A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. Bioactivity details MOA