efonidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 992 111011-63-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • efonidipine
  • efonidipine hydrochloride
  • zeria
  • efonidipine HCl
  • Molecular weight: 631.67
  • Formula: C34H38N3O7P
  • CLOGP: 6.54
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 1
  • TPSA: 120.24
  • ALOGS: -6.41
  • ROTB: 11

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004232 Diuretics
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35620 vasodilator agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.96 Basic
pKa2 2.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER DRUG LABEL SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.62 SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel BLOCKER IC50 7 IUPHAR

External reference:

IDSource
D07886 KEGG_DRUG
3BR983K69O UNII
111011-53-1 SECONDARY_CAS_RN
6852 INN_ID
010907 NDDF
DB09235 DRUGBANK_ID
CHEBI:135859 CHEBI
C066425 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2074922 ChEMBL_ID
119171 PUBCHEM_CID

Pharmaceutical products:

None