dyclonine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 974 586-60-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dyclonine
  • dyclonine hydrochloride
  • dyclocaine
  • dyclonin
  • dyclonine HCl
minor descriptor (66-83); on-line & Index Medicus search PROPIOPHENONES (66-83); RN given refers to parent cpd; structure
  • Molecular weight: 289.42
  • Formula: C18H27NO2
  • CLOGP: 4.83
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -3.80
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart rate abnormal 136.77 23.88 34 2876 4913 63481199
Blood magnesium decreased 107.84 23.88 35 2875 13163 63472949
Productive cough 104.38 23.88 53 2857 63155 63422957
Lymphadenitis 92.97 23.88 23 2887 3252 63482860
Muscle twitching 90.51 23.88 34 2876 19634 63466478
Broncholithiasis 85.39 23.88 14 2896 239 63485873
Infection 83.66 23.88 75 2835 229098 63257014
Lymph node calcification 81.59 23.88 14 2896 318 63485794
Soft tissue disorder 81.40 23.88 22 2888 4400 63481712
Clostridium difficile infection 76.71 23.88 34 2876 29888 63456224
Pneumonia viral 60.61 23.88 20 2890 7902 63478210
Bronchial wall thickening 60.54 23.88 14 2896 1485 63484627
Thrombosis 52.04 23.88 34 2876 64721 63421391
Soft tissue swelling 46.96 23.88 11 2899 1233 63484879
Lichen nitidus 44.76 23.88 7 2903 87 63486025
Liver function test abnormal 42.91 23.88 27 2883 48154 63437958
Lymphadenopathy 40.52 23.88 24 2886 38434 63447678
Completed suicide 40.29 23.88 41 2869 145632 63340480
White blood cell count decreased 40.03 23.88 40 2870 139064 63347048
Febrile neutropenia 39.61 23.88 37 2873 118412 63367700
Platelet count decreased 38.30 23.88 36 2874 116086 63370026
Therapeutic product effect incomplete 37.90 23.88 37 2873 125019 63361093
Leukopenia 37.75 23.88 30 2880 77260 63408852
Herpes zoster 36.05 23.88 30 2880 82432 63403680
Sexual abuse 32.24 23.88 6 2904 218 63485894
Tenderness 31.66 23.88 17 2893 22561 63463551
Toxicity to various agents 31.41 23.88 47 2863 247203 63238909
Arthritis 30.89 23.88 32 2878 115889 63370223
Blood cholesterol increased 30.70 23.88 29 2881 94003 63392109
Oral pain 30.63 23.88 18 2892 28376 63457736
Fibromyalgia 30.55 23.88 27 2883 80393 63405719
Soft tissue necrosis 26.48 23.88 6 2904 581 63485531
Obstructive airways disorder 24.66 23.88 14 2896 20685 63465427

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Choroiditis 83.72 32.26 16 898 1199 34954818
Endophthalmitis 77.30 32.26 18 896 3490 34952527
Completed suicide 64.95 32.26 37 877 98131 34857886
Visual acuity reduced 57.79 32.26 20 894 16129 34939888
Condition aggravated 57.34 32.26 44 870 192152 34763865
Intraocular pressure increased 55.30 32.26 15 899 5368 34950649
Eye pain 49.42 32.26 17 897 13445 34942572
Toxicity to various agents 37.21 32.26 35 879 200327 34755690

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart rate abnormal 129.78 23.99 34 3634 6023 79734697
Muscle twitching 100.14 23.99 39 3629 24725 79715995
Blood magnesium decreased 99.99 23.99 35 3633 16477 79724243
Productive cough 87.52 23.99 53 3615 88278 79652442
Lymphadenitis 84.85 23.99 23 3645 4632 79736088
Completed suicide 82.63 23.99 77 3591 245690 79495030
Broncholithiasis 78.85 23.99 13 3655 229 79740491
Clostridium difficile infection 76.73 23.99 38 3630 42647 79698073
Lymph node calcification 71.85 23.99 13 3655 402 79740318
Choroiditis 67.06 23.99 15 3653 1366 79739354
Infection 61.30 23.99 65 3603 241647 79499073
Toxicity to various agents 53.28 23.99 80 3588 421460 79319260
Endophthalmitis 52.21 23.99 17 3651 6411 79734309
Bronchial wall thickening 47.89 23.99 13 3655 2628 79738092
Pneumonia viral 46.32 23.99 17 3651 9141 79731579
Soft tissue swelling 44.87 23.99 11 3657 1490 79739230
Lichen nitidus 44.52 23.99 7 3661 90 79740630
Thrombosis 43.89 23.99 34 3634 84066 79656654
Soft tissue disorder 39.87 23.99 12 3656 3503 79737217
Soft tissue necrosis 39.34 23.99 9 3659 906 79739814
Lymphadenopathy 37.95 23.99 26 3642 53221 79687499
Intraocular pressure increased 35.43 23.99 14 3654 9191 79731529
Tenderness 33.64 23.99 18 3650 23624 79717096
Visual acuity reduced 32.56 23.99 19 3649 29450 79711270
Therapeutic product effect incomplete 30.47 23.99 35 3633 141610 79599110
White blood cell count decreased 30.00 23.99 40 3628 188248 79552472
Eye pain 28.32 23.99 19 3649 37559 79703161
Skin atrophy 26.66 23.99 10 3658 5708 79735012
Psoriasis 26.08 23.99 26 3642 89561 79651159
Platelet count decreased 24.56 23.99 37 3631 194627 79546093

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01BX02 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Other local anesthetics
ATC R02AD04 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Anesthetics, local
CHEBI has role CHEBI:48425 topical anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Suppression of the Gag Reflex indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Mouth Irritation indication
Conduction disorder of the heart contraindication 44808001
Bleeding hemorrhoids contraindication 51551000
Decreased respiratory function contraindication 80954004
Disorder of mucous membrane contraindication 95351003
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Denuded skin contraindication 418242004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.79 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Acetylcholinesterase Enzyme IC50 6.74 CHEMBL

External reference:

IDSource
4019739 VUID
N0000147831 NUI
D00735 KEGG_DRUG
536-43-6 SECONDARY_CAS_RN
4018913 VANDF
4019739 VANDF
C0058831 UMLSCUI
CHEBI:4724 CHEBI
N8R PDB_CHEM_ID
CHEMBL1201217 ChEMBL_ID
DB00645 DRUGBANK_ID
CHEMBL1200478 ChEMBL_ID
C100063 MESH_SUPPLEMENTAL_RECORD_UI
3180 PUBCHEM_CID
7173 IUPHAR_LIGAND_ID
640 INN_ID
078A24Q30O UNII
23744 RXNORM
4647 MMSL
72161 MMSL
001336 NDDF
005055 NDDF
23564005 SNOMEDCT_US
370307004 SNOMEDCT_US
57164003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DycloPro HUMAN PRESCRIPTION DRUG LABEL 1 0362-3971 SOLUTION 5 mg TOPICAL ANDA 18 sections
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.23 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride and Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 0363-0210 LIQUID 0.23 mg TOPICAL OTC monograph not final 15 sections
Ambix First Aid HUMAN OTC DRUG LABEL 2 10038-250 CREAM 0.01 g TOPICAL OTC monograph not final 11 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11673-629 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 11822-0128 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium Chloride and Dyclonine Hydrochloride HUMAN OTC DRUG LABEL 2 11822-0779 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 30142-150 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 30142-150 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 36800-382 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 36800-382 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 37808-512 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 37808-512 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41250-132 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41250-132 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41520-089 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 41520-089 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 46122-525 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 46122-525 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 50804-755 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 50804-755 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 55910-144 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 55910-144 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 56104-040 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 56104-040 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Premier Solutions Liquid Bandage HUMAN OTC DRUG LABEL 2 56104-246 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Premier Solutions Liquid Bandage HUMAN OTC DRUG LABEL 2 56104-246 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections
Benzethonium chloride Plus Dyclonine hydrochloride HUMAN OTC DRUG LABEL 2 59779-385 LIQUID 0.75 mg TOPICAL OTC monograph not final 15 sections