drotaverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| spasmolytics with a papaverine-like action | 969 | 14009-24-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Hungarian drug; RN given refers to parent cpd; structure
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
| 0.10 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 7.90 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 58 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.90 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 3.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 9.30 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 13.75 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Abdominal pain | 46.26 | 41.95 | 32 | 607 | 389537 | 79354212 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03AD02 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Papaverine and derivatives |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D010276 | Parasympatholytics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.16 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Enzyme | WOMBAT-PK | |||||||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D07088 | KEGG_DRUG |
| 985-12-6 | SECONDARY_CAS_RN |
| C0058762 | UMLSCUI |
| CHEBI:135630 | CHEBI |
| CHEMBL551978 | ChEMBL_ID |
| DB06751 | DRUGBANK_ID |
| C005317 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1712095 | PUBCHEM_CID |
| 2239 | INN_ID |
| 98QS4N58TW | UNII |
| 23684 | RXNORM |
| 007309 | NDDF |
| 007310 | NDDF |
| 1173005008 | SNOMEDCT_US |
| 1173007000 | SNOMEDCT_US |
| 719933003 | SNOMEDCT_US |
Pharmaceutical products:
None