doxercalciferol indications/contra

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 957 54573-75-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hectorol
  • doxercalciferol
decrease of bone density caused by prednisolone was prevented by above cpd; decreases number of osteoclast areas in normal rats; RN given refers to (1alpha,3beta,5Z,7E,22E)-isomer
  • Molecular weight: 412.66
  • Formula: C28H44O2
  • CLOGP: 8.16
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
June 9, 1999 FDA GENZYME CORP

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypersensitivity 239.49 49.67 57 229 27843 3357730
Dyspnoea 177.94 49.67 60 226 102874 3282699
Pruritus 167.96 49.67 48 238 46785 3338788
Unresponsive to stimuli 76.01 49.67 18 268 7990 3377583
Flushing 70.59 49.67 19 267 14094 3371479
Vomiting 51.48 49.67 24 262 89507 3296066
Feeling hot 50.85 49.67 13 273 7823 3377750

Pharmacologic Action:

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SourceCodeDescription
ATC H05BX03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
ANTI-PARATHYROID AGENTS
Other anti-parathyroid agents
FDA Chemical/Ingredient N0000006337 Ergocalciferols
FDA EPC N0000175907 Vitamin D2 Analog
CHEBI has role CHEBI:50646 bone density conservation agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis indication
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Hypoparathyroidism contraindication 36976004 DOID:11199
Hypercalcemia contraindication 66931009 DOID:12678
Disease of liver contraindication 235856003 DOID:409
Hyperparathyroidism Secondary to Chronic Renal Failure off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST UNKNOWN CHEMBL

External reference:

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IDSource
2790 IUPHAR_LIGAND_ID
4021201 VUID
N0000179007 NUI
C0043668 UMLSCUI
D01009 KEGG_DRUG
3DIZ9LF5Y9 UNII
7878 INN_ID
4021201 VANDF
N0000179007 NDFRT
N0000148647 NDFRT
007891 NDDF
116094003 SNOMEDCT_US
11516 RXNORM
d04435 MMSL
8230 MMSL
126234006 SNOMEDCT_US
211288 MMSL
5281107 PUBCHEM_CID
CHEMBL1200810 ChEMBL_ID
DB06410 DRUGBANK_ID
C042533 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:4712 CHEBI
V2H PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0338 CAPSULE 0.50 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0339 CAPSULE 2.50 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0388 CAPSULE 1 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6154 INJECTION 2 ug INTRAVENOUS ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0781-3304 INJECTION, SOLUTION 2 ug INTRAVENOUS ANDA 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0781-3305 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1720 CAPSULE 0.50 ug ORAL NDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1721 CAPSULE 1 ug ORAL NDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1722 CAPSULE 2.50 ug ORAL NDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 17478-987 INJECTION, SOLUTION 2 ug INTRAVENOUS ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 17478-988 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 12 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0120 CAPSULE, LIQUID FILLED 0.50 ug ORAL NDA 11 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0121 CAPSULE, LIQUID FILLED 2.50 ug ORAL NDA 11 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0123 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 12 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0124 CAPSULE, LIQUID FILLED 1 ug ORAL NDA 11 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0126 INJECTION, SOLUTION 2 ug INTRAVENOUS NDA 12 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0127 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64980-228 CAPSULE 0.50 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64980-229 CAPSULE 1 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64980-230 CAPSULE 2.50 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 66993-185 CAPSULE, LIQUID FILLED 0.50 ug ORAL NDA authorized generic 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 66993-186 CAPSULE, LIQUID FILLED 1 ug ORAL NDA authorized generic 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 66993-187 CAPSULE, LIQUID FILLED 2.50 ug ORAL NDA authorized generic 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 68084-872 CAPSULE 0.50 ug ORAL ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 69189-0187 CAPSULE, LIQUID FILLED 2.50 ug ORAL NDA authorized generic 11 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 70121-1392 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 70121-1393 INJECTION, SOLUTION 2 ug INTRAVENOUS ANDA 12 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 70121-1408 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 12 sections