doxercalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 957 54573-75-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hectorol
  • doxercalciferol
decrease of bone density caused by prednisolone was prevented by above cpd; decreases number of osteoclast areas in normal rats; RN given refers to (1alpha,3beta,5Z,7E,22E)-isomer
  • Molecular weight: 412.66
  • Formula: C28H44O2
  • CLOGP: 8.16
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
June 9, 1999 FDA GENZYME CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 185.77 32.78 103 1306 310584 63177029
Peritonitis bacterial 69.17 32.78 17 1392 4862 63482751
Pruritus 63.66 32.78 57 1352 361396 63126217
Dyspnoea 50.41 32.78 67 1342 661246 62826367
Blood parathyroid hormone abnormal 43.53 32.78 7 1402 225 63487388
Vomiting 41.45 32.78 56 1353 559561 62928052
Unresponsive to stimuli 40.05 32.78 18 1391 33798 63453815

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 149.92 33.32 68 1214 80461 34875188
Pruritus 60.08 33.32 46 1236 141935 34813714
Unresponsive to stimuli 46.95 33.32 22 1260 27547 34928102
Dyspnoea 39.80 33.32 58 1224 376724 34578925
Flushing 37.78 33.32 20 1262 32400 34923249
Blood parathyroid hormone increased 36.88 33.32 9 1273 1505 34954144
Blood parathyroid hormone abnormal 35.53 33.32 6 1276 156 34955493

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 331.25 30.67 169 2379 298747 79443093
Pruritus 104.70 30.67 92 2456 394556 79347284
Peritonitis bacterial 89.96 30.67 26 2522 9541 79732299
Unresponsive to stimuli 83.39 30.67 39 2509 55749 79686091
Dyspnoea 63.34 30.67 104 2444 856921 78884919
Peritoneal dialysis complication 59.28 30.67 14 2534 2340 79739500
Vomiting 52.03 30.67 83 2465 665745 79076095
Blood parathyroid hormone abnormal 50.62 30.67 9 2539 366 79741474
Flushing 48.71 30.67 32 2516 88236 79653604
Blood parathyroid hormone increased 44.44 30.67 12 2536 3433 79738407
Feeling hot 38.77 30.67 24 2524 59710 79682130
Nephrogenic systemic fibrosis 33.48 30.67 11 2537 6149 79735691
Nausea 33.06 30.67 85 2463 957111 78784729

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC H05BX03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CALCIUM HOMEOSTASIS
ANTI-PARATHYROID AGENTS
Other anti-parathyroid agents
FDA CS M0007651 Ergocalciferols
CHEBI has role CHEBI:50188 provitamins
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:71212 prohormones
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175907 Vitamin D2 Analog

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis indication
Hyperparathyroidism Secondary to Chronic Renal Failure off-label use
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Hypoparathyroidism contraindication 36976004 DOID:11199
Hypercalcemia contraindication 66931009 DOID:12678
Disease of liver contraindication 235856003 DOID:409




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST UNKNOWN CHEMBL

External reference:

IDSource
4021201 VUID
N0000179007 NUI
D01009 KEGG_DRUG
4021201 VANDF
C0043668 UMLSCUI
CHEBI:4712 CHEBI
V2H PDB_CHEM_ID
CHEMBL1200810 ChEMBL_ID
DB06410 DRUGBANK_ID
C042533 MESH_SUPPLEMENTAL_RECORD_UI
5281107 PUBCHEM_CID
2790 IUPHAR_LIGAND_ID
7878 INN_ID
3DIZ9LF5Y9 UNII
11516 RXNORM
211288 MMSL
30992 MMSL
8230 MMSL
d04435 MMSL
007891 NDDF
116094003 SNOMEDCT_US
126234006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0338 CAPSULE 0.50 ug ORAL ANDA 24 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0339 CAPSULE 2.50 ug ORAL ANDA 24 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0054-0388 CAPSULE 1 ug ORAL ANDA 24 sections
DOXERCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 0409-1330 INJECTION, SOLUTION 2 ug INTRAVENOUS NDA 26 sections
DOXERCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 0409-1331 INJECTION, SOLUTION 2 ug INTRAVENOUS NDA 26 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0641-6154 INJECTION 2 ug INTRAVENOUS ANDA 23 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1720 CAPSULE 0.50 ug ORAL NDA authorized generic 26 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1721 CAPSULE 1 ug ORAL NDA authorized generic 26 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 0955-1722 CAPSULE 2.50 ug ORAL NDA authorized generic 26 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 17478-987 INJECTION, SOLUTION 2 ug INTRAVENOUS ANDA 25 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 17478-988 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 25 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 23155-538 CAPSULE 0.50 ug ORAL ANDA 22 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 23155-539 CAPSULE 1 ug ORAL ANDA 22 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 23155-540 CAPSULE 2.50 ug ORAL ANDA 22 sections
DOXERCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 43598-850 INJECTION 4 ug INTRAVENOUS ANDA 24 sections
Doxercalciferol Human Prescription Drug Label 1 55150-357 INJECTION, SOLUTION 2 ug INTRAVENOUS ANDA 24 sections
Doxercalciferol Human Prescription Drug Label 1 55150-358 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 24 sections
Doxercalciferol Human Prescription Drug Label 1 55150-359 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 24 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0123 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 26 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0123 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 26 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0126 INJECTION, SOLUTION 2 ug INTRAVENOUS NDA 26 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0126 INJECTION, SOLUTION 2 ug INTRAVENOUS NDA 26 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0127 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 26 sections
Hectorol HUMAN PRESCRIPTION DRUG LABEL 1 58468-0127 INJECTION, SOLUTION 4 ug INTRAVENOUS NDA 26 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 62135-450 CAPSULE 0.50 ug ORAL ANDA 17 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 62135-451 CAPSULE 1 ug ORAL ANDA 17 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 62135-452 CAPSULE 2.50 ug ORAL ANDA 17 sections
Doxercalciferol Human Prescription Drug Label 1 62332-690 INJECTION, SOLUTION 4 ug INTRAVENOUS ANDA 23 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64980-228 CAPSULE 0.50 ug ORAL ANDA 30 sections
Doxercalciferol HUMAN PRESCRIPTION DRUG LABEL 1 64980-228 CAPSULE 0.50 ug ORAL ANDA 30 sections