dorzolamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 949 | 120279-96-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
topically effective ocular hypotensive carbonic anhydrase inhibitor; RN refers to mono-HCl (4S-trans)-isomer
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.30 | ml | None |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 14 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.08 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 9, 1994 | FDA | MERCK |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Intraocular pressure increased | 304.09 | 16.27 | 83 | 8213 | 5995 | 63474731 |
| Eye irritation | 287.31 | 16.27 | 108 | 8188 | 21863 | 63458863 |
| Treatment failure | 278.05 | 16.27 | 220 | 8076 | 198823 | 63281903 |
| Eye pain | 147.72 | 16.27 | 77 | 8219 | 33777 | 63446949 |
| Ocular hyperaemia | 132.53 | 16.27 | 65 | 8231 | 25079 | 63455647 |
| Visual acuity reduced | 113.75 | 16.27 | 56 | 8240 | 21770 | 63458956 |
| Glaucoma | 109.06 | 16.27 | 52 | 8244 | 18853 | 63461873 |
| Product quality issue | 105.60 | 16.27 | 63 | 8233 | 35802 | 63444924 |
| Product delivery mechanism issue | 71.04 | 16.27 | 15 | 8281 | 357 | 63480369 |
| Ocular surface disease | 64.62 | 16.27 | 10 | 8286 | 34 | 63480692 |
| Choroidal detachment | 59.92 | 16.27 | 12 | 8284 | 218 | 63480508 |
| Corneal oedema | 54.72 | 16.27 | 16 | 8280 | 1477 | 63479249 |
| Hypotony of eye | 51.98 | 16.27 | 10 | 8286 | 146 | 63480580 |
| Product packaging quantity issue | 51.74 | 16.27 | 15 | 8281 | 1344 | 63479382 |
| Burns second degree | 50.28 | 16.27 | 16 | 8280 | 1962 | 63478764 |
| Catarrh | 49.80 | 16.27 | 15 | 8281 | 1534 | 63479192 |
| Steroid dependence | 47.88 | 16.27 | 15 | 8281 | 1749 | 63478977 |
| Product container issue | 47.64 | 16.27 | 15 | 8281 | 1778 | 63478948 |
| No adverse event | 45.51 | 16.27 | 40 | 8256 | 41365 | 63439361 |
| Punctate keratitis | 43.09 | 16.27 | 11 | 8285 | 610 | 63480116 |
| Iridocyclitis | 42.61 | 16.27 | 15 | 8281 | 2507 | 63478219 |
| Choroidal effusion | 40.87 | 16.27 | 10 | 8286 | 466 | 63480260 |
| Thermal burns of eye | 39.60 | 16.27 | 8 | 8288 | 152 | 63480574 |
| Vision blurred | 39.29 | 16.27 | 54 | 8242 | 91870 | 63388856 |
| Hypopnoea | 36.61 | 16.27 | 15 | 8281 | 3791 | 63476935 |
| Iritis | 35.69 | 16.27 | 14 | 8282 | 3161 | 63477565 |
| Visual impairment | 33.69 | 16.27 | 48 | 8248 | 84398 | 63396328 |
| Bradycardia | 31.25 | 16.27 | 43 | 8253 | 73184 | 63407542 |
| Glaucoma surgery | 31.23 | 16.27 | 6 | 8290 | 87 | 63480639 |
| Gingival pain | 31.15 | 16.27 | 17 | 8279 | 8145 | 63472581 |
| Trabeculectomy | 31.11 | 16.27 | 5 | 8291 | 23 | 63480703 |
| Eye pruritus | 31.07 | 16.27 | 23 | 8273 | 18648 | 63462078 |
| Accidental overdose | 30.70 | 16.27 | 25 | 8271 | 23284 | 63457442 |
| Ulcerative keratitis | 30.64 | 16.27 | 12 | 8284 | 2698 | 63478028 |
| Superficial injury of eye | 30.64 | 16.27 | 7 | 8289 | 242 | 63480484 |
| Hyphaema | 29.36 | 16.27 | 7 | 8289 | 292 | 63480434 |
| Foreign body sensation in eyes | 29.22 | 16.27 | 11 | 8285 | 2223 | 63478503 |
| Acute generalised exanthematous pustulosis | 28.80 | 16.27 | 18 | 8278 | 11081 | 63469645 |
| Visual field defect | 28.80 | 16.27 | 15 | 8281 | 6546 | 63474180 |
| Intraocular pressure test abnormal | 27.58 | 16.27 | 6 | 8290 | 165 | 63480561 |
| Conjunctival follicles | 25.99 | 16.27 | 4 | 8292 | 13 | 63480713 |
| Rectal haemorrhage | 25.92 | 16.27 | 32 | 8264 | 48998 | 63431728 |
| Dysgeusia | 25.52 | 16.27 | 31 | 8265 | 46679 | 63434047 |
| Erythema of eyelid | 25.41 | 16.27 | 10 | 8286 | 2276 | 63478450 |
| Joint swelling | 25.11 | 16.27 | 6 | 8290 | 327660 | 63153066 |
| Conjunctival hyperaemia | 25.03 | 16.27 | 10 | 8286 | 2369 | 63478357 |
| Lacrimation increased | 24.83 | 16.27 | 21 | 8275 | 20610 | 63460116 |
| Conjunctivitis | 24.68 | 16.27 | 21 | 8275 | 20775 | 63459951 |
| Abnormal sensation in eye | 24.29 | 16.27 | 9 | 8287 | 1740 | 63478986 |
| Corneal deposits | 24.27 | 16.27 | 6 | 8290 | 292 | 63480434 |
| Parosmia | 23.89 | 16.27 | 13 | 8283 | 6193 | 63474533 |
| Conjunctival erosion | 23.68 | 16.27 | 5 | 8291 | 119 | 63480607 |
| Cataract | 23.59 | 16.27 | 33 | 8263 | 57020 | 63423706 |
| Rhinitis | 23.53 | 16.27 | 16 | 8280 | 11350 | 63469376 |
| Impaired quality of life | 22.98 | 16.27 | 17 | 8279 | 13766 | 63466960 |
| Genital erythema | 22.47 | 16.27 | 4 | 8292 | 37 | 63480689 |
| Swollen tongue | 22.18 | 16.27 | 25 | 8271 | 34775 | 63445951 |
| Product dose omission issue | 22.04 | 16.27 | 74 | 8222 | 234239 | 63246487 |
| Confusional state | 21.66 | 16.27 | 74 | 8222 | 236306 | 63244420 |
| Intraocular pressure fluctuation | 21.52 | 16.27 | 4 | 8292 | 48 | 63480678 |
| Conjunctivitis allergic | 21.41 | 16.27 | 7 | 8289 | 935 | 63479791 |
| Retinal disorder | 20.94 | 16.27 | 8 | 8288 | 1682 | 63479044 |
| Cardiac murmur | 19.99 | 16.27 | 16 | 8280 | 14536 | 63466190 |
| Thyroxine decreased | 19.61 | 16.27 | 6 | 8290 | 647 | 63480079 |
| Conjunctival oedema | 19.18 | 16.27 | 6 | 8290 | 696 | 63480030 |
| Eye complication associated with device | 18.81 | 16.27 | 3 | 8293 | 13 | 63480713 |
| Eye discharge | 18.74 | 16.27 | 11 | 8285 | 6052 | 63474674 |
| Intraocular lens implant | 18.62 | 16.27 | 5 | 8291 | 338 | 63480388 |
| Tinnitus | 18.42 | 16.27 | 23 | 8273 | 35605 | 63445121 |
| Blindness | 18.12 | 16.27 | 18 | 8278 | 21681 | 63459045 |
| Hypoglycaemia | 18.10 | 16.27 | 30 | 8266 | 60035 | 63420691 |
| Nightmare | 18.05 | 16.27 | 17 | 8279 | 19177 | 63461549 |
| Product package associated injury | 17.72 | 16.27 | 3 | 8293 | 20 | 63480706 |
| Uveitis | 17.67 | 16.27 | 14 | 8282 | 12539 | 63468187 |
| Retinal vascular occlusion | 17.54 | 16.27 | 5 | 8291 | 422 | 63480304 |
| Eye disorder | 17.45 | 16.27 | 18 | 8278 | 22667 | 63458059 |
| Macular oedema | 17.41 | 16.27 | 9 | 8287 | 3868 | 63476858 |
| Blepharitis | 17.26 | 16.27 | 8 | 8288 | 2717 | 63478009 |
| Eczema eyelids | 17.04 | 16.27 | 4 | 8292 | 156 | 63480570 |
| Ocular hypertension | 16.81 | 16.27 | 6 | 8290 | 1044 | 63479682 |
| Palpitations | 16.77 | 16.27 | 42 | 8254 | 112728 | 63367998 |
| Eyelid margin crusting | 16.69 | 16.27 | 6 | 8290 | 1066 | 63479660 |
| Eye swelling | 16.65 | 16.27 | 18 | 8278 | 23900 | 63456826 |
| Bronchiectasis | 16.55 | 16.27 | 15 | 8281 | 16127 | 63464599 |
| Device deposit issue | 16.46 | 16.27 | 3 | 8293 | 32 | 63480694 |
| Eyelid irritation | 16.35 | 16.27 | 5 | 8291 | 538 | 63480188 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Intraocular pressure increased | 308.24 | 18.80 | 88 | 6358 | 5295 | 34945190 |
| Treatment failure | 251.97 | 18.80 | 137 | 6309 | 46560 | 34903925 |
| Eye irritation | 205.89 | 18.80 | 70 | 6376 | 7491 | 34942994 |
| Eye pain | 150.02 | 18.80 | 65 | 6381 | 13397 | 34937088 |
| Visual acuity reduced | 102.76 | 18.80 | 53 | 6393 | 16096 | 34934389 |
| Ocular hyperaemia | 97.99 | 18.80 | 46 | 6400 | 11406 | 34939079 |
| Corneal oedema | 63.63 | 18.80 | 19 | 6427 | 1332 | 34949153 |
| Ocular surface disease | 61.78 | 18.80 | 11 | 6435 | 69 | 34950416 |
| Glaucoma | 59.84 | 18.80 | 28 | 6418 | 6884 | 34943601 |
| Anterior chamber disorder | 55.59 | 18.80 | 10 | 6436 | 67 | 34950418 |
| Vision blurred | 50.95 | 18.80 | 52 | 6394 | 45911 | 34904574 |
| Blepharitis | 49.81 | 18.80 | 16 | 6430 | 1429 | 34949056 |
| Choroidal detachment | 48.55 | 18.80 | 12 | 6434 | 410 | 34950075 |
| Lacrimation increased | 45.90 | 18.80 | 25 | 6421 | 8457 | 34942028 |
| Hyphaema | 44.62 | 18.80 | 12 | 6434 | 575 | 34949910 |
| Product container issue | 42.21 | 18.80 | 12 | 6434 | 707 | 34949778 |
| Product delivery mechanism issue | 42.08 | 18.80 | 9 | 6437 | 159 | 34950326 |
| Product quality issue | 40.90 | 18.80 | 30 | 6416 | 17005 | 34933480 |
| Eye pruritus | 37.57 | 18.80 | 21 | 6425 | 7468 | 34943017 |
| Burns second degree | 36.87 | 18.80 | 12 | 6434 | 1117 | 34949368 |
| Cataract | 35.31 | 18.80 | 33 | 6413 | 26153 | 34924332 |
| Product packaging quantity issue | 34.97 | 18.80 | 11 | 6435 | 918 | 34949567 |
| Catarrh | 34.15 | 18.80 | 11 | 6435 | 991 | 34949494 |
| Steroid dependence | 33.40 | 18.80 | 12 | 6434 | 1505 | 34948980 |
| Ectropion | 33.04 | 18.80 | 7 | 6439 | 118 | 34950367 |
| Blindness | 32.86 | 18.80 | 25 | 6421 | 14961 | 34935524 |
| Iridocyclitis | 32.40 | 18.80 | 12 | 6434 | 1640 | 34948845 |
| Product substitution issue | 31.78 | 18.80 | 21 | 6425 | 10074 | 34940411 |
| Scleral hyperaemia | 30.70 | 18.80 | 6 | 6440 | 66 | 34950419 |
| Intraocular pressure test abnormal | 30.22 | 18.80 | 6 | 6440 | 72 | 34950413 |
| Blindness unilateral | 29.13 | 18.80 | 15 | 6431 | 4527 | 34945958 |
| Hypopnoea | 28.60 | 18.80 | 12 | 6434 | 2277 | 34948208 |
| Parosmia | 27.93 | 18.80 | 12 | 6434 | 2413 | 34948072 |
| Congenital muscle absence | 27.13 | 18.80 | 5 | 6441 | 39 | 34950446 |
| Congenital vas deferens absence | 27.13 | 18.80 | 5 | 6441 | 39 | 34950446 |
| Thermal burns of eye | 25.68 | 18.80 | 4 | 6442 | 9 | 34950476 |
| No adverse event | 25.49 | 18.80 | 26 | 6420 | 22901 | 34927584 |
| Gingival pain | 25.29 | 18.80 | 12 | 6434 | 3040 | 34947445 |
| Cardioactive drug level increased | 24.85 | 18.80 | 10 | 6436 | 1707 | 34948778 |
| Ocular hypertension | 23.68 | 18.80 | 8 | 6438 | 836 | 34949649 |
| Conjunctival oedema | 23.63 | 18.80 | 7 | 6439 | 477 | 34950008 |
| Systemic lupus erythematosus | 23.03 | 18.80 | 12 | 6434 | 3712 | 34946773 |
| Myopic chorioretinal degeneration | 22.80 | 18.80 | 3 | 6443 | 0 | 34950485 |
| Erythema of eyelid | 22.79 | 18.80 | 8 | 6438 | 937 | 34949548 |
| Eye swelling | 22.63 | 18.80 | 17 | 6429 | 9978 | 34940507 |
| Dysgeusia | 22.39 | 18.80 | 26 | 6420 | 26471 | 34924014 |
| Eye inflammation | 22.38 | 18.80 | 10 | 6436 | 2208 | 34948277 |
| Rhinitis | 21.95 | 18.80 | 14 | 6432 | 6324 | 34944161 |
| Foreign body sensation in eyes | 21.77 | 18.80 | 7 | 6439 | 627 | 34949858 |
| Ulcerative keratitis | 21.39 | 18.80 | 9 | 6437 | 1720 | 34948765 |
| Dry eye | 21.05 | 18.80 | 16 | 6430 | 9559 | 34940926 |
| Impaired work ability | 20.80 | 18.80 | 14 | 6432 | 6916 | 34943569 |
| Eye discharge | 20.10 | 18.80 | 9 | 6437 | 1997 | 34948488 |
| Visual acuity tests abnormal | 19.99 | 18.80 | 4 | 6442 | 50 | 34950435 |
| Choroidal effusion | 19.76 | 18.80 | 5 | 6441 | 188 | 34950297 |
| Uveitis | 19.74 | 18.80 | 14 | 6432 | 7521 | 34942964 |
| Corneal bleeding | 19.50 | 18.80 | 3 | 6443 | 6 | 34950479 |
| Visual impairment | 19.09 | 18.80 | 28 | 6418 | 35774 | 34914711 |
| Single umbilical artery | 19.00 | 18.80 | 5 | 6441 | 220 | 34950265 |
| Corneal transplant | 18.96 | 18.80 | 4 | 6442 | 66 | 34950419 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Intraocular pressure increased | 433.02 | 14.74 | 122 | 11234 | 9083 | 79723949 |
| Eye irritation | 227.93 | 14.74 | 92 | 11264 | 20589 | 79712443 |
| Visual acuity reduced | 181.25 | 14.74 | 87 | 11269 | 29382 | 79703650 |
| Eye pain | 152.92 | 14.74 | 84 | 11272 | 37494 | 79695538 |
| Ocular hyperaemia | 125.75 | 14.74 | 67 | 11289 | 28139 | 79704893 |
| Ocular surface disease | 120.84 | 14.74 | 20 | 11336 | 103 | 79732929 |
| Corneal oedema | 102.03 | 14.74 | 30 | 11326 | 2590 | 79730442 |
| Glaucoma | 88.23 | 14.74 | 47 | 11309 | 19714 | 79713318 |
| Choroidal detachment | 88.06 | 14.74 | 20 | 11336 | 616 | 79732416 |
| Burns second degree | 76.26 | 14.74 | 24 | 11332 | 2604 | 79730428 |
| Blepharitis | 76.19 | 14.74 | 25 | 11331 | 3099 | 79729933 |
| Steroid dependence | 72.10 | 14.74 | 23 | 11333 | 2607 | 79730425 |
| Catarrh | 72.09 | 14.74 | 22 | 11334 | 2156 | 79730876 |
| Anterior chamber disorder | 56.87 | 14.74 | 11 | 11345 | 151 | 79732881 |
| Hypopnoea | 56.24 | 14.74 | 23 | 11333 | 5306 | 79727726 |
| Hyphaema | 51.78 | 14.74 | 14 | 11342 | 890 | 79732142 |
| Gingival pain | 50.58 | 14.74 | 25 | 11331 | 8973 | 79724059 |
| Parosmia | 50.16 | 14.74 | 23 | 11333 | 6991 | 79726041 |
| Iridocyclitis | 49.64 | 14.74 | 19 | 11337 | 3685 | 79729347 |
| Iritis | 48.90 | 14.74 | 19 | 11337 | 3836 | 79729196 |
| Choroidal effusion | 45.99 | 14.74 | 12 | 11344 | 665 | 79732367 |
| Vision blurred | 45.16 | 14.74 | 65 | 11291 | 105833 | 79627199 |
| Cataract | 42.09 | 14.74 | 48 | 11308 | 62072 | 79670960 |
| Visual field defect | 41.74 | 14.74 | 22 | 11334 | 9023 | 79724009 |
| Rhinitis | 41.45 | 14.74 | 26 | 11330 | 14781 | 79718251 |
| Lacrimation increased | 40.37 | 14.74 | 30 | 11326 | 22447 | 79710585 |
| Trabeculectomy | 40.09 | 14.74 | 7 | 11349 | 52 | 79732980 |
| Dysgeusia | 36.75 | 14.74 | 43 | 11313 | 57134 | 79675898 |
| Conjunctival hyperaemia | 36.43 | 14.74 | 16 | 11340 | 4397 | 79728635 |
| Swollen tongue | 36.03 | 14.74 | 37 | 11319 | 42533 | 79690499 |
| Ulcerative keratitis | 35.81 | 14.74 | 15 | 11341 | 3674 | 79729358 |
| Cardiac murmur | 35.05 | 14.74 | 24 | 11332 | 15800 | 79717232 |
| Impaired quality of life | 34.69 | 14.74 | 23 | 11333 | 14363 | 79718669 |
| Eye discharge | 34.61 | 14.74 | 17 | 11339 | 6017 | 79727015 |
| Accidental overdose | 34.59 | 14.74 | 35 | 11321 | 39546 | 79693486 |
| Intraocular pressure test abnormal | 33.90 | 14.74 | 7 | 11349 | 136 | 79732896 |
| Product quality issue | 33.35 | 14.74 | 32 | 11324 | 33908 | 79699124 |
| Ocular hypertension | 32.43 | 14.74 | 11 | 11345 | 1509 | 79731523 |
| Product substitution issue | 31.89 | 14.74 | 25 | 11331 | 20231 | 79712801 |
| Eye pruritus | 31.55 | 14.74 | 25 | 11331 | 20545 | 79712487 |
| Conjunctival oedema | 31.22 | 14.74 | 10 | 11346 | 1148 | 79731884 |
| Blindness | 30.26 | 14.74 | 28 | 11328 | 28355 | 79704677 |
| Product container issue | 30.15 | 14.74 | 10 | 11346 | 1281 | 79731751 |
| Rectal haemorrhage | 29.87 | 14.74 | 45 | 11311 | 76255 | 79656777 |
| Hypotony of eye | 29.79 | 14.74 | 7 | 11349 | 251 | 79732781 |
| Bronchiectasis | 29.70 | 14.74 | 25 | 11331 | 22361 | 79710671 |
| Glaucoma surgery | 29.49 | 14.74 | 6 | 11350 | 108 | 79732924 |
| Conjunctivitis | 28.65 | 14.74 | 26 | 11330 | 25689 | 79707343 |
| Punctate keratitis | 28.59 | 14.74 | 9 | 11347 | 977 | 79732055 |
| Nightmare | 28.52 | 14.74 | 26 | 11330 | 25835 | 79707197 |
| Impaired work ability | 28.23 | 14.74 | 23 | 11333 | 19658 | 79713374 |
| Tinnitus | 27.92 | 14.74 | 33 | 11323 | 44300 | 79688732 |
| Corneal neovascularisation | 27.32 | 14.74 | 6 | 11350 | 158 | 79732874 |
| Eye complication associated with device | 26.79 | 14.74 | 5 | 11351 | 56 | 79732976 |
| Ectropion | 26.27 | 14.74 | 7 | 11349 | 421 | 79732611 |
| Growth of eyelashes | 26.19 | 14.74 | 6 | 11350 | 192 | 79732840 |
| Frequent bowel movements | 25.59 | 14.74 | 26 | 11330 | 29513 | 79703519 |
| Corneal deposits | 25.22 | 14.74 | 7 | 11349 | 491 | 79732541 |
| Foreign body sensation in eyes | 25.14 | 14.74 | 10 | 11346 | 2147 | 79730885 |
| Eye inflammation | 25.14 | 14.74 | 14 | 11342 | 6399 | 79726633 |
| Uveitis | 24.84 | 14.74 | 20 | 11336 | 16810 | 79716222 |
| Conjunctival follicles | 24.80 | 14.74 | 4 | 11352 | 17 | 79733015 |
| Confusional state | 24.64 | 14.74 | 100 | 11256 | 317897 | 79415135 |
| Blindness unilateral | 24.56 | 14.74 | 15 | 11341 | 8131 | 79724901 |
| Erythema of eyelid | 23.45 | 14.74 | 10 | 11346 | 2560 | 79730472 |
| Eczema | 23.45 | 14.74 | 29 | 11327 | 40789 | 79692243 |
| Scleral hyperaemia | 23.44 | 14.74 | 6 | 11350 | 308 | 79732724 |
| Corneal transplant | 22.85 | 14.74 | 6 | 11350 | 341 | 79732691 |
| Retinal detachment | 22.82 | 14.74 | 15 | 11341 | 9232 | 79723800 |
| Floppy iris syndrome | 22.58 | 14.74 | 6 | 11350 | 357 | 79732675 |
| Visual impairment | 22.41 | 14.74 | 44 | 11312 | 92087 | 79640945 |
| Bradycardia | 21.95 | 14.74 | 55 | 11301 | 135502 | 79597530 |
| Product delivery mechanism issue | 21.51 | 14.74 | 5 | 11351 | 171 | 79732861 |
| Intraocular pressure decreased | 21.34 | 14.74 | 5 | 11351 | 177 | 79732855 |
| Corneal disorder | 21.19 | 14.74 | 9 | 11347 | 2282 | 79730750 |
| Eczema eyelids | 21.10 | 14.74 | 5 | 11351 | 186 | 79732846 |
| Eye disorder | 21.00 | 14.74 | 21 | 11335 | 23391 | 79709641 |
| Conjunctival scar | 20.46 | 14.74 | 5 | 11351 | 212 | 79732820 |
| Acute generalised exanthematous pustulosis | 20.31 | 14.74 | 18 | 11338 | 17236 | 79715796 |
| Cardioactive drug level increased | 19.94 | 14.74 | 10 | 11346 | 3699 | 79729333 |
| Corneal lesion | 19.66 | 14.74 | 4 | 11352 | 72 | 79732960 |
| Retinal vascular occlusion | 19.53 | 14.74 | 6 | 11350 | 601 | 79732431 |
| Vertigo | 19.29 | 14.74 | 35 | 11321 | 69047 | 79663985 |
| Haematochezia | 19.10 | 14.74 | 40 | 11316 | 87605 | 79645427 |
| Palpitations | 19.08 | 14.74 | 50 | 11306 | 126560 | 79606472 |
| Tubulointerstitial nephritis | 18.57 | 14.74 | 25 | 11331 | 38210 | 79694822 |
| Hyperaemia | 18.55 | 14.74 | 9 | 11347 | 3101 | 79729931 |
| Hypoglycaemia | 18.34 | 14.74 | 43 | 11313 | 101551 | 79631481 |
| Eye operation | 18.19 | 14.74 | 8 | 11348 | 2205 | 79730827 |
| Medication error | 18.18 | 14.74 | 34 | 11322 | 68608 | 79664424 |
| Visual acuity tests abnormal | 17.78 | 14.74 | 4 | 11352 | 118 | 79732914 |
| Thyroxine decreased | 17.39 | 14.74 | 6 | 11350 | 867 | 79732165 |
| Colitis ulcerative | 17.30 | 14.74 | 23 | 11333 | 34719 | 79698313 |
| Eye swelling | 17.16 | 14.74 | 20 | 11336 | 26448 | 79706584 |
| Eyelid irritation | 16.73 | 14.74 | 5 | 11351 | 456 | 79732576 |
| Conjunctivitis allergic | 16.72 | 14.74 | 7 | 11349 | 1713 | 79731319 |
| Iris hyperpigmentation | 16.29 | 14.74 | 3 | 11353 | 31 | 79733001 |
| Conjunctival erosion | 15.95 | 14.74 | 4 | 11352 | 189 | 79732843 |
| Superficial injury of eye | 15.77 | 14.74 | 4 | 11352 | 198 | 79732834 |
| Device deposit issue | 15.39 | 14.74 | 3 | 11353 | 43 | 79732989 |
| Hepatic cytolysis | 15.13 | 14.74 | 19 | 11337 | 27132 | 79705900 |
| Metamorphopsia | 15.09 | 14.74 | 6 | 11350 | 1287 | 79731745 |
| Endophthalmitis | 14.83 | 14.74 | 10 | 11346 | 6418 | 79726614 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | S01EC03 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Carbonic anhydrase inhibitors |
| FDA MoA | N0000000235 | Carbonic Anhydrase Inhibitors |
| FDA EPC | N0000175517 | Carbonic Anhydrase Inhibitor |
| CHEBI has role | CHEBI:23018 | EC 4.2.1.1 inhibitor |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:39456 | antiglaucoma agent |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002257 | Carbonic Anhydrase Inhibitors |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ocular hypertension | indication | 4210003 | DOID:9282 |
| Open-angle glaucoma | indication | 84494001 | DOID:1067 |
| Bronchospasm | contraindication | 4386001 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Anaphylaxis | contraindication | 39579001 | |
| Sinus bradycardia | contraindication | 49710005 | |
| General anesthesia | contraindication | 50697003 | |
| Acute nephropathy | contraindication | 58574008 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Cardiogenic shock | contraindication | 89138009 | |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Partial atrioventricular block | contraindication | 195039008 | |
| Decompensated cardiac failure | contraindication | 195111005 | |
| Hypoglycemic disorder | contraindication | 237630007 | |
| Pregnancy, function | contraindication | 289908002 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.73 | acidic |
| pKa2 | 8.34 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Enzyme | INHIBITOR | Ki | 9.70 | CHEMBL | CHEMBL | |||
| Carbonic anhydrase 14 | Enzyme | Ki | 7.57 | CHEMBL | |||||
| Androgen receptor | Nuclear hormone receptor | IC50 | 7.19 | CHEMBL | |||||
| Carbonic anhydrase 1 | Enzyme | Ki | 6.30 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 7.37 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 7.28 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 8.46 | CHEMBL | |||||
| Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 7.38 | CHEMBL | |||||
| Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 7.48 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 8.46 | CHEMBL | |||||
| Carbonic anhydrase 3 | Enzyme | Ki | 5.10 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 7.74 | CHEMBL | |||||
| Carbonic anhydrase 6 | Enzyme | Ki | 8 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 5.37 | CHEMBL | |||||
| Androgen receptor | Transcription factor | Ki | 7.96 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 7.74 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 7.37 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 6.39 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 4.51 | CHEMBL | |||||
| Carbonic anhydrase 15 | Enzyme | Ki | 7.21 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 6.96 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 8.05 | CHEMBL | |||||
| Probable transmembrane carbonic anhydrase (Carbonate dehydratase) (Carbonic dehydratase); Transmembrane carbonic anhydrase | Enzyme | Ki | 6.86 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 5.18 | CHEMBL | |||||
| Alpha carbonic anhydrase | Enzyme | Ki | 7.74 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 6.95 | CHEMBL | |||||
| Carbonic anhydrase 2 | Enzyme | Ki | 5.08 | CHEMBL | |||||
| Astrosclerin-3 | Enzyme | Ki | 6.55 | CHEMBL | |||||
| Beta-carbonic anhydrase 1 | Enzyme | Ki | 6.13 | CHEMBL | |||||
| Delta carbonic anhydrase | Unclassified | Ki | 7.30 | CHEMBL | |||||
| Carbonic anhydrase 2 | Enzyme | Ki | 7 | CHEMBL | |||||
| Carbonic anhydrase | Enzyme | Ki | 6.56 | CHEMBL | |||||
| Carbonic anhydrase, alpha family | Unclassified | Ki | 8.15 | CHEMBL | |||||
| Carbonate dehydratase | Enzyme | Ki | 8.10 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4023982 | VUID |
| N0000021987 | NUI |
| D00653 | KEGG_DRUG |
| 130693-82-2 | SECONDARY_CAS_RN |
| 4020910 | VANDF |
| 4023982 | VANDF |
| C0165590 | UMLSCUI |
| CHEBI:4702 | CHEBI |
| ETS | PDB_CHEM_ID |
| CHEMBL218490 | ChEMBL_ID |
| DB00869 | DRUGBANK_ID |
| CHEMBL1201162 | ChEMBL_ID |
| C062765 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5284549 | PUBCHEM_CID |
| 6810 | IUPHAR_LIGAND_ID |
| 6960 | INN_ID |
| 9JDX055TW1 | UNII |
| 236065 | RXNORM |
| 158838 | MMSL |
| 29194 | MMSL |
| 4634 | MMSL |
| 004998 | NDDF |
| 004999 | NDDF |
| 108834004 | SNOMEDCT_US |
| 126154004 | SNOMEDCT_US |
| 373447009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| TRUSOPT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-3519 | SOLUTION | 20 mg | OPHTHALMIC | NDA | 26 sections |
| TRUSOPT | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0006-3519 | SOLUTION | 20 mg | OPHTHALMIC | NDA | 26 sections |
| Dorzolamide Hydrochloride-Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-1763 | SOLUTION | 20 mg | OPHTHALMIC | ANDA | 25 sections |
| Dorzolamide Hydrochloride | Human Prescription Drug Label | 1 | 14445-404 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALETAE | Human Prescription Drug Label | 2 | 14445-405 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide HCl and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-514 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 28 sections |
| COSOPT PF | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-604 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 26 sections |
| COSOPT PF | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-604 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 26 sections |
| COSOPT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-605 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 28 sections |
| COSOPT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-605 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 28 sections |
| Dorzolamide HCl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-485 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide HCl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-485 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 24208-486 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 24208-486 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 24208-486 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride Ophthalmic Solution | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-141 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42571-147 | SOLUTION/ DROPS | 22.30 mg | OPHTHALMIC | ANDA | 24 sections |
| DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42571-382 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1246 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1247 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1247 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide HCl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2406 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide HCl | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2768 | SOLUTION | 20 mg | OPHTHALMIC | ANDA | 25 sections |
| Dorzolamide HCl and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-2867 | SOLUTION | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride Ophthalmic | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4882 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| DORZOLAMIDE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5280 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 26 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-6371 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-232 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-232 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |
| Dorzolamide Hydrochloride and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50383-233 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 24 sections |