adiphenine indications/contra

Stem definitionDrug idCAS RN
94 64-95-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adiphenine
  • adiphenin
  • diphacil
  • diphenylacetic acid diethylaminoethyl ester
  • tranzetil
  • trasentin
  • trasentine
  • adiphenine hydrochloride
  • adiphenine HCl
  • Molecular weight: 311.43
  • Formula: C20H25NO2
  • CLOGP: 4.53
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 29.54
  • ALOGS: -4.39
  • ROTB: 9

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.44 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor GPCR Kd 7.45 CHEMBL
Histamine H1 receptor GPCR IC50 4.77 CHEMBL

External reference:

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IDSource
C0001521 UMLSCUI
D02772 KEGG_DRUG
42B4PDY0AV UNII
50-42-0 SECONDARY_CAS_RN
004710 NDDF
333 RXNORM
21394008 SNOMEDCT_US
CHEMBL353846 ChEMBL_ID
2031 PUBCHEM_CID
CHEMBL555654 ChEMBL_ID
C084829 MESH_SUPPLEMENTAL_RECORD_UI
2715 INN_ID
CHEBI:94680 CHEBI

Pharmaceutical products:

None