adinazolam indications/contra

Stem definitionDrug idCAS RN
diazepam derivatives 93 37115-32-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adinazolam
  • adinazolam mesylate
  • adinazolam mesilate
  • deracyn
  • Molecular weight: 351.84
  • Formula: C19H18ClN5
  • CLOGP: 2.12
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 46.31
  • ALOGS: -3.72
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N05BA07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35717 sedative
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35623 anticonvulsant
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.71 Basic
pKa2 5.26 Basic
pKa3 3.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor Ion channel POSITIVE ALLOSTERIC MODULATOR SCIENTIFIC LITERATURE KEGG DRUG
Translocator protein Transporter IC50 7.10 WOMBAT-PK

External reference:

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IDSource
DB00546 DRUGBANK_ID
D02770 KEGG_DRUG
CHEMBL328250 ChEMBL_ID
37632 PUBCHEM_CID
C074080 MESH_SUPPLEMENTAL_RECORD_UI
C039668 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2106672 ChEMBL_ID
KN08449444 UNII
4996 INN_ID
57938-82-6 SECONDARY_CAS_RN
CHEBI:251412 CHEBI

Pharmaceutical products:

None