adinazolam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 93 37115-32-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adinazolam
  • adinazolam mesylate
  • adinazolam mesilate
  • deracyn
  • Molecular weight: 351.84
  • Formula: C19H18ClN5
  • CLOGP: 2.12
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 0
  • TPSA: 46.31
  • ALOGS: -3.72
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.65 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 39 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.98 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.31 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.07 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA07 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35717 hypnotics

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anxiety indication 48694002




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.71 Basic
pKa2 5.26 Basic
pKa3 3.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor Ion channel POSITIVE ALLOSTERIC MODULATOR SCIENTIFIC LITERATURE KEGG DRUG
Translocator protein Transporter IC50 7.10 WOMBAT-PK

External reference:

IDSource
D02770 KEGG_DRUG
C0050844 UMLSCUI
CHEBI:251412 CHEBI
CHEMBL328250 ChEMBL_ID
DB00546 DRUGBANK_ID
C039668 MESH_SUPPLEMENTAL_RECORD_UI
37632 PUBCHEM_CID
C074080 MESH_SUPPLEMENTAL_RECORD_UI
4996 INN_ID
57938-82-6 SECONDARY_CAS_RN
KN08449444 UNII
CHEMBL2106672 ChEMBL_ID

Pharmaceutical products:

None