adenosine phosphate indications/contra

Stem definitionDrug idCAS RN
92 61-19-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • adenosine phosphate
  • adenosine 5'-phosphate
  • adenovite
  • 5'-Adenylic acid
  • adenylic acid
  • phosphentaside
  • adenosine 5'-monophosphate
  • AMP
  • adenosine monophosphate
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
  • Molecular weight: 347.22
  • Formula: C10H14N5O7P
  • CLOGP: -4.08
  • LIPINSKI: 1
  • HAC: 12
  • HDO: 5
  • TPSA: 186.07
  • ALOGS: -2.02
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 19.65 0 4 5 35676 3350174

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:50733 nutraceutical

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Cystic fibrosis of the lung indication 86555001
Bronchiectasis contraindication 12295008 DOID:9563

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.31 acidic
pKa2 6.36 acidic
pKa3 12.46 acidic
pKa4 13.04 acidic
pKa5 3.95 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Transient receptor potential cation channel subfamily M member 4 Ion channel IC50 4.70 IUPHAR
Fructose-1,6-bisphosphatase 1 Enzyme IC50 6.85 CHEMBL
Proto-oncogene tyrosine-protein kinase Src Kinase IC50 7 CHEMBL
Transient receptor potential cation channel subfamily M member 2 Ion channel IC50 4.15 CHEMBL
L-lactate dehydrogenase A chain Enzyme Kd 3.19 CHEMBL
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Enzyme Ki 4.72 CHEMBL
Ketopantoate reductase Unclassified Ki 2.20 CHEMBL
Pol polyprotein Enzyme Ki 9.64 CHEMBL
Adenylate kinase 2 Unclassified Ki 4.10 CHEMBL
Fructose-1,6-bisphosphatase 1 Enzyme IC50 5.89 CHEMBL
Alcohol dehydrogenase Enzyme Ki 4.42 CHEMBL
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Unclassified Ki 4.40 CHEMBL

External reference:

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IDSource
DB00131 DRUGBANK_ID
4018975 VUID
N0000170817 NUI
C0001465 UMLSCUI
2455 IUPHAR_LIGAND_ID
D02769 KEGG_DRUG
415SHH325A UNII
335 INN_ID
CHEMBL752 ChEMBL_ID
4018975 VANDF
NOCODE MMSL
309 RXNORM
N0000170817 NDFRT
N0000147254 NDFRT
002392 NDDF
4136 MMSL
1085 MMSL
4137 MMSL
6083 PUBCHEM_CID
DB00640 DRUGBANK_ID
D000249 MESH_DESCRIPTOR_UI
CHEBI:16027 CHEBI

Pharmaceutical products:

None