adenosine phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 92 | 61-19-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 2.67 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D058913 | Purinergic Agonists |
| MeSH PA | D058906 | Purinergic P1 Receptor Agonists |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| FDA MoA | N0000175788 | Adenosine Receptor Agonists |
| FDA EPC | N0000178375 | Adenosine Receptor Agonist |
| CHEBI has role | CHEBI:23357 | cofactor |
| CHEBI has role | CHEBI:27027 | trace elements |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:63332 | alkaline phosphatase inhibitors |
| CHEBI has role | CHEBI:65056 | FBPase inhibitor |
| CHEBI has role | CHEBI:65057 | adenosine A1 receptor agonists |
| CHEBI has role | CHEBI:78675 | fundamental metabolites |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cystic fibrosis of the lung | indication | 86555001 | |
| Bronchiectasis | contraindication | 12295008 | DOID:9563 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.31 | acidic |
| pKa2 | 6.36 | acidic |
| pKa3 | 12.46 | acidic |
| pKa4 | 13.04 | acidic |
| pKa5 | 3.95 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Fructose-1,6-bisphosphatase 1 | Enzyme | IC50 | 6.85 | CHEMBL | |||||
| Proto-oncogene tyrosine-protein kinase Src | Kinase | IC50 | 7 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily M member 2 | Ion channel | IC50 | 4.15 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily M member 4 | Ion channel | GATING INHIBITOR | IC50 | 4.70 | IUPHAR | ||||
| L-lactate dehydrogenase A chain | Enzyme | Kd | 3.19 | CHEMBL | |||||
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Enzyme | Ki | 4.72 | CHEMBL | |||||
| Fructose-1,6-bisphosphatase 1 | Enzyme | IC50 | 5.89 | CHEMBL | |||||
| Pol polyprotein | Enzyme | Ki | 9.64 | CHEMBL | |||||
| Alcohol dehydrogenase | Enzyme | Ki | 4.42 | CHEMBL | |||||
| Ketopantoate reductase | Enzyme | Ki | 2.20 | CHEMBL | |||||
| Adenylate kinase 2 | Kinase | Ki | 4.10 | CHEMBL | |||||
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Enzyme | Ki | 4.40 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 415SHH325A | UNII |
| 4018975 | VUID |
| N0000170817 | NUI |
| D02769 | KEGG_DRUG |
| 296 | RXNORM |
| C0001465 | UMLSCUI |
| CHEBI:16027 | CHEBI |
| CHEBI:16335 | CHEBI |
| A | PDB_CHEM_ID |
| ADN | PDB_CHEM_ID |
| CHEMBL752 | ChEMBL_ID |
| 6083 | PUBCHEM_CID |
| DB00131 | DRUGBANK_ID |
| 335 | INN_ID |
| 2455 | IUPHAR_LIGAND_ID |
| 108502004 | SNOMEDCT_US |
| 35431001 | SNOMEDCT_US |
| 4864008 | SNOMEDCT_US |
| 54941006 | SNOMEDCT_US |
| D000249 | MESH_DESCRIPTOR_UI |
| C0001443 | UMLSCUI |
| DB00640 | DRUGBANK_ID |
| 4018975 | VANDF |
| 4019507 | VANDF |
| 1085 | MMSL |
| 4135 | MMSL |
| 4136 | MMSL |
| 4137 | MMSL |
| 57772 | MMSL |
| NOCODE | MMSL |
| d00164 | MMSL |
| D000241 | MESH_DESCRIPTOR_UI |
| 60961 | PUBCHEM_CID |
| 002392 | NDDF |
| 003603 | NDDF |
| 004537 | NDDF |
| 004813 | NDDF |
Pharmaceutical products:
None