digitoxin indications/contra

Stem definitionDrug idCAS RN
881 71-63-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • digitoxin
  • digitoxoside
  • cardidigin
  • cardigin
  • carditoxin
  • coramedan
  • cristapurat
  • crystodigin
  • digicor
  • digipural
  • digisidin
  • digitophyllin
  • digitoxigenin tridigitoxoside
  • myodigin
  • purpurid
  • tradigal
  • unidigin
A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
  • Molecular weight: 764.95
  • Formula: C41H64O13
  • CLOGP: 2.85
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 5
  • TPSA: 182.83
  • ALOGS: -4.42
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.10 mg O
0.10 mg P

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradyarrhythmia 78.91 56.97 10 48 581 3385220

Pharmacologic Action:

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SourceCodeDescription
ATC C01AA04 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter INHIBITOR WOMBAT-PK CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.86 WOMBAT-PK
Sodium/potassium-transporting ATPase Transporter IC50 8.10 CHEMBL
Signal transducer and activator of transcription 3 Transcription factor IC50 6.15 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-2 Ion channel IC50 6.65 DRUG MATRIX
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter IC50 8.10 CHEMBL

External reference:

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IDSource
4017429 VUID
N0000145817 NUI
C0012258 UMLSCUI
6782 IUPHAR_LIGAND_ID
D00297 KEGG_DRUG
3403 RXNORM
373534001 SNOMEDCT_US
81728006 SNOMEDCT_US
4596 MMSL
d00209 MMSL
4017429 VANDF
N0000005895 NDFRT
N0000145817 NDFRT
000592 NDDF
CHEMBL254219 ChEMBL_ID
D004074 MESH_DESCRIPTOR_UI
E90NZP2L9U UNII
1547 INN_ID
DB01396 DRUGBANK_ID
441207 PUBCHEM_CID
CHEBI:28544 CHEBI

Pharmaceutical products:

None