Stem definition | Drug id | CAS RN |
---|---|---|
881 | 71-63-6 |
Dose | Unit | Route |
---|---|---|
0.10 | mg | O |
0.10 | mg | P |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA | LILLY |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Bradyarrhythmia | 78.91 | 56.97 | 10 | 48 | 581 | 3385220 |
Source | Code | Description |
---|---|---|
ATC | C01AA04 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D002316 | Cardiotonic Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D020011 | Protective Agents |
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.86 | WOMBAT-PK | |||||
Sodium/potassium-transporting ATPase | Transporter | IC50 | 8.10 | CHEMBL | |||||
Signal transducer and activator of transcription 3 | Transcription factor | IC50 | 6.15 | CHEMBL | |||||
Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 6.65 | DRUG MATRIX | |||||
Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | IC50 | 8.10 | CHEMBL |
ID | Source |
---|---|
4017429 | VUID |
N0000145817 | NUI |
C0012258 | UMLSCUI |
6782 | IUPHAR_LIGAND_ID |
D00297 | KEGG_DRUG |
3403 | RXNORM |
373534001 | SNOMEDCT_US |
81728006 | SNOMEDCT_US |
4596 | MMSL |
d00209 | MMSL |
4017429 | VANDF |
N0000005895 | NDFRT |
N0000145817 | NDFRT |
000592 | NDDF |
CHEMBL254219 | ChEMBL_ID |
D004074 | MESH_DESCRIPTOR_UI |
E90NZP2L9U | UNII |
1547 | INN_ID |
DB01396 | DRUGBANK_ID |
441207 | PUBCHEM_CID |
CHEBI:28544 | CHEBI |
None