diethylpropion indications/contra

Stem definitionDrug idCAS RN
anorexics 874 90-84-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diethylpropion
  • adiposon
  • amfepramon
  • amfepramone
  • amphepramon
  • amphepramone
  • diethpropion
  • diethylpropione
  • nopropiophenone
  • diethylpropion hydrochloride
  • amfepramone hydrochloride
  • diethylpropion HCl
  • amfepramone HCl
A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
  • Molecular weight: 205.30
  • Formula: C13H19NO
  • CLOGP: 2.85
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -2.23
  • ROTB: 5

Drug dosage:

DoseUnitRoute
75 mg O

Approvals:

DateAgencyCompanyOrphan
Aug. 6, 1959 FDA ACTAVIS LABS UT INC

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A08AA03 ALIMENTARY TRACT AND METABOLISM
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
Centrally acting antiobesity products
CHEBI has role CHEBI:50507 appetite depressant
MeSH PA D019440 Anti-Obesity Agents
MeSH PA D001067 Appetite Depressants
MeSH PA D002491 Central Nervous System Agents
FDA PE N0000175372 Appetite Suppression
FDA PE N0000175651 Increased Sympathetic Activity
FDA EPC N0000175423 Sympathomimetic Amine Anorectic

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Obesity indication 414916001 DOID:9970
Heart valve disorder contraindication 368009 DOID:4079
Alcoholism contraindication 7200002
Glaucoma contraindication 23986001 DOID:1686
Feeling agitated contraindication 24199005
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus type 1 contraindication 46635009 DOID:9744
Chronic heart failure contraindication 48447003
Substance abuse contraindication 66214007
Pulmonary hypertension contraindication 70995007 DOID:6432
Arteriosclerotic vascular disease contraindication 72092001 DOID:2349
Epilepsy contraindication 84757009 DOID:1826
Drug-induced psychosis contraindication 191483003 DOID:1742
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Hypertensive urgency contraindication 443482000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.17 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter INHIBITOR CHEMBL CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4019717 VUID
N0000147809 NUI
C0012201 UMLSCUI
7161 IUPHAR_LIGAND_ID
D03801 KEGG_DRUG
19V2PL39NG UNII
134-80-5 SECONDARY_CAS_RN
DB00937 DRUGBANK_ID
7029 PUBCHEM_CID
3389 RXNORM
387303009 SNOMEDCT_US
54882005 SNOMEDCT_US
d00810 MMSL
4019717 VANDF
N0000005815 NDFRT
N0000147809 NDFRT
004773 NDDF
CHEBI:4530 CHEBI
CHEMBL1693 ChEMBL_ID
CHEMBL1194666 ChEMBL_ID
D004053 MESH_DESCRIPTOR_UI
974 INN_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1475 TABLET 25 mg ORAL ANDA 13 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1477 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
Diethylpropion HCl Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 0591-0782 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion HCl Immediate-Release HUMAN PRESCRIPTION DRUG LABEL 1 0591-0783 TABLET 25 mg ORAL NDA 12 sections
Diethylpropion HCl Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 10544-598 TABLET 75 mg ORAL ANDA 13 sections
DIETHYLPROPION HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 10702-044 TABLET 25 mg ORAL ANDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 12634-530 TABLET 25 mg ORAL NDA 12 sections
diethylpropion hydrochloride er HUMAN PRESCRIPTION DRUG LABEL 1 12634-691 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion HCl Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 21695-876 TABLET 75 mg ORAL NDA 13 sections
DIETHYLPROPION HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 33261-353 TABLET 25 mg ORAL ANDA 13 sections
Diethylpropion HydrochlorideER HUMAN PRESCRIPTION DRUG LABEL 1 33261-354 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
DIETHYLPROPION HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 43063-348 TABLET 25 mg ORAL ANDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-532 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0120 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
Diethylpropion HCl Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 50090-0121 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion HCl Immediate-Release HUMAN PRESCRIPTION DRUG LABEL 1 50090-0326 TABLET 25 mg ORAL NDA 12 sections
DIETHYLPROPION HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 50090-0327 TABLET 25 mg ORAL ANDA 12 sections
DIETHYLPROPION HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 50436-4164 TABLET 25 mg ORAL ANDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 52959-329 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 11 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 53217-230 TABLET 25 mg ORAL ANDA 13 sections
Diethylpropion HCl HUMAN PRESCRIPTION DRUG LABEL 1 54868-1462 TABLET 25 mg ORAL NDA 12 sections
Diethylpropion HCl HUMAN PRESCRIPTION DRUG LABEL 1 54868-1463 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion Hydrochloride Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 55289-368 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion HCl Immediate-Release HUMAN PRESCRIPTION DRUG LABEL 1 55289-794 TABLET 25 mg ORAL NDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 63187-621 TABLET, EXTENDED RELEASE 75 mg ORAL ANDA 12 sections
Diethylpropion Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 63187-947 TABLET 25 mg ORAL ANDA 13 sections
Diethylpropion HCl HUMAN PRESCRIPTION DRUG LABEL 1 63629-2967 TABLET 75 mg ORAL NDA 12 sections
Diethylpropion HCl Immediate-Release HUMAN PRESCRIPTION DRUG LABEL 1 63629-4010 TABLET 25 mg ORAL NDA 12 sections
Diethylpropion HCl Immediate-Release HUMAN PRESCRIPTION DRUG LABEL 1 66267-076 TABLET 25 mg ORAL NDA 12 sections
Diethylpropion HCl Controlled-Release HUMAN PRESCRIPTION DRUG LABEL 1 66267-077 TABLET 75 mg ORAL NDA 12 sections