diaziquone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
853 57998-68-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diaziquone
  • aziridinylbenzoquinone
  • Molecular weight: 364.36
  • Formula: C16H20N4O6
  • CLOGP: 0.52
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 2
  • TPSA: 116.82
  • ALOGS: -2.21
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IRAK1,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ULK2 73
kinase-selectivity-class ACVR2B,AURKB,AXL,BRAF,CAMK2D,CDK16,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3A,GSK3B,IRAK1,JAK2,MAP2K4,MAP2K6,MAP3K14,MAP3K7,MAPK12,MAPK7,MARK4,MET,PDK1,PIM3,PRKAA1,PRKDC,SIK2,STK33,SYK,TEK,TTK 36
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000970 Antineoplastic Agents
MeSH PA D003432 Cross-Linking Reagents
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:22333 alkylating agent
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.61 acidic
pKa2 8.95 acidic
pKa3 4.61 Basic
pKa4 3.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D03774 KEGG_DRUG
C0113600 UMLSCUI
CHEBI:90185 CHEBI
CHEMBL36016 ChEMBL_ID
DB17174 DRUGBANK_ID
C029108 MESH_SUPPLEMENTAL_RECORD_UI
42616 PUBCHEM_CID
5124 INN_ID
FQL5EUP13W UNII

Pharmaceutical products:

None