dextrothyroxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	846	51-49-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

sodium dextrothyroxine
D-Thyroxine
choloxin
dextrothyroxine
dextrothyroxine sodium

The dextrorotary isomer of the synthetic THYROXINE.

Molecular weight: 776.87
Formula: C15H11I4NO4
CLOGP: 3.21
LIPINSKI: 1
HAC: 5
HDO: 3
TPSA: 92.78
ALOGS: -4.94
ROTB: 5

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
4	mg	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
April 14, 1967	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C10AX01	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, PLAIN Other lipid modifying agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hyperlipidemia	indication	55822004	DOID:1168

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.08	acidic
pKa2	6.63	acidic
pKa3	8.6	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Thyroid hormone receptor	Nuclear hormone receptor	P10827 P10828	THA_HUMAN THB_HUMAN	AGONIST				CHEMBL	CHEMBL
Thyroid hormone receptor beta	Transcription factor		THB_RAT		IC50	7.46		CHEMBL
Glutamate NMDA receptor	Ion channel		NMDZ1_RAT NMDE1_RAT NMDE2_RAT NMDE3_RAT NMDE4_RAT NMD3B_RAT NMD3A_RAT		IC50	6.48		CHEMBL

External reference:

ID	Source
4022400	VUID
N0000020406	NUI
D03750	KEGG_DRUG
227544	RXNORM
4018501	VANDF
4022400	VANDF
C0011824	UMLSCUI
CHEBI:30659	CHEBI
CHEMBL559	ChEMBL_ID
CHEMBL3545058	ChEMBL_ID
D003918	MESH_DESCRIPTOR_UI
DB00509	DRUGBANK_ID
6951	IUPHAR_LIGAND_ID
7054-08-2	SECONDARY_CAS_RN
4W9K63FION	UNII
8730	PUBCHEM_CID
308	MMSL
4569	MMSL
d00747	MMSL
002055	NDDF
004779	NDDF
59170000	SNOMEDCT_US
61899008	SNOMEDCT_US
847003	SNOMEDCT_US
CHEMBL1200777	ChEMBL_ID

Pharmaceutical products:

None