dexniguldipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 837 120054-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • niguldipine hydrobromide
  • niguldipine fumarate
  • niguldipine hydrochloride
  • niguldipine HCl
  • B859-35
  • B 859-35
  • B8509-035
  • dexniguldipine
  • (+)-Niguldipine
  • (R)-Niguldipine
  • Molecular weight: 609.72
  • Formula: C36H39N3O6
  • CLOGP: 7.85
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -6.73
  • ROTB: 12

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.38 Basic
pKa2 2.37 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.82 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 7.43 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.05 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 6.77 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 10 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 7.25 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 6.18 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 6.35 CHEMBL
Adenosine receptor A3 GPCR Ki 5.72 CHEMBL
Voltage-gated L-type calcium channel Ion channel Ki 7.22 CHEMBL
Adenosine receptor A1 GPCR Ki 4.38 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 8.20 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 6.42 CHEMBL
D(2) dopamine receptor GPCR Ki 6.53 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 9.42 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 7.08 CHEMBL

External reference:

IDSource
1G8C7QS9SR UNII
113145-69-0 SECONDARY_CAS_RN
CHEMBL405355 ChEMBL_ID
6938 INN_ID
CHEBI:7572 CHEBI
463 IUPHAR_LIGAND_ID
DB14068 DRUGBANK_ID
CHEMBL2051956 ChEMBL_ID
6918097 PUBCHEM_CID
C054074 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None