dexamethasone palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 828 14899-36-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone palmitate
  • limethason
  • limethasone
a liposteroid for treatment of hemophagocytic lymphohistiocytosis
  • Molecular weight: 630.88
  • Formula: C38H59FO6
  • CLOGP: 9.73
  • LIPINSKI: 2
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -6.76
  • ROTB: 18

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.08 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 13.41 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor Ki 8.26 CHEMBL
Mineralocorticoid receptor Nuclear hormone receptor IC50 7.48 CHEMBL
Androgen receptor Nuclear hormone receptor Ki 5.85 CHEMBL
Progesterone receptor Nuclear hormone receptor Ki 6.25 CHEMBL
Androgen receptor Transcription factor IC50 4.09 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 4.66 CHEMBL
Progesterone receptor Transcription factor IC50 4.63 CHEMBL
Glucocorticoid receptor Transcription factor IC50 7.66 CHEMBL

External reference:

IDSource
D01615 KEGG_DRUG
3264 RXNORM
4017922 VANDF
C5222049 UMLSCUI
CHEBI:31471 CHEBI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL384467 ChEMBL_ID
C035081 MESH_SUPPLEMENTAL_RECORD_UI
601XWN7060 UNII
63044 PUBCHEM_CID
DB01234 DRUGBANK_ID
4552 MMSL
6848 MMSL
d00206 MMSL
002174 NDDF
018179 NDDF
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US
C0011777 UMLSCUI
816 INN_ID
5743 PUBCHEM_CID
D003907 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None