dexamethasone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
826 1177-87-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexamethasone acetate
  • decadronal
  • neofordex
  • Molecular weight: 434.50
  • Formula: C24H31FO6
  • CLOGP: 2.32
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.42
  • ROTB: 4

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.08 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Sept. 6, 1973 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutrophil count decreased 441.41 31.31 160 4218 56246 63428398
Platelet count decreased 388.55 31.31 179 4199 115943 63368701
Lymphocyte count decreased 175.01 31.31 69 4309 30188 63454456
White blood cell count decreased 174.05 31.31 112 4266 138992 63345652
Anaemia 150.74 31.31 139 4239 293291 63191353
Fracture 117.88 31.31 46 4332 19538 63465106
Plasma cell myeloma 91.11 31.31 46 4332 35859 63448785
Thrombocytopenia 68.46 31.31 67 4311 151090 63333554
Dementia 62.52 31.31 29 4349 18765 63465879
Myelosuppression 61.96 31.31 31 4347 23672 63460972
Tumour lysis syndrome 60.79 31.31 23 4355 8967 63475677
Neutropenia 51.82 31.31 62 4316 174943 63309701
Drug ineffective 51.63 31.31 6 4372 1044759 62439885
Vitiligo 50.95 31.31 13 4365 1376 63483268
Ileus 49.84 31.31 23 4355 14702 63469942
Febrile neutropenia 48.96 31.31 50 4328 118399 63366245
Renal impairment 47.28 31.31 43 4335 88312 63396332
Upper respiratory tract inflammation 43.27 31.31 13 4365 2510 63482134
Decreased appetite 41.27 31.31 67 4311 250985 63233659
Neuropathy peripheral 39.90 31.31 44 4334 113623 63371021
Pneumonia 39.63 31.31 93 4285 456674 63027970
Bone marrow failure 35.02 31.31 23 4355 29267 63455377
Osteonecrosis of jaw 33.52 31.31 24 4354 35099 63449545
Pyrexia 32.61 31.31 88 4290 470390 63014254
Renal disorder 32.55 31.31 23 4355 32951 63451693
Cardiac amyloidosis 31.66 31.31 8 4370 814 63483830
Fatigue 31.64 31.31 11 4367 888017 62596627

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 269.80 26.78 179 4559 119538 34832655
Neutrophil count decreased 230.54 26.78 120 4618 50984 34901209
Lymphocyte count decreased 107.13 26.78 55 4683 22567 34929626
White blood cell count decreased 90.41 26.78 86 4652 95359 34856834
Pneumonia 85.42 26.78 165 4573 362462 34589731
Anaemia 58.14 26.78 109 4629 233226 34718967
Dementia 55.31 26.78 30 4708 13718 34938475
Nephritis allergic 51.38 26.78 12 4726 441 34951752
Plasma cell myeloma 47.74 26.78 42 4696 41995 34910198
Bone marrow failure 43.12 26.78 34 4704 29219 34922974
Conjunctival irritation 42.38 26.78 8 4730 101 34952092
Tumour lysis syndrome 39.29 26.78 26 4712 17033 34935160
Neutropenia 38.63 26.78 73 4665 156705 34795488
Liver disorder 37.51 26.78 33 4705 32964 34919229
Thrombocytopenia 36.33 26.78 71 4667 156176 34796017
Osteonecrosis of jaw 35.81 26.78 25 4713 17864 34934329
Upper respiratory tract inflammation 35.38 26.78 12 4726 1732 34950461
Genital erythema 35.20 26.78 8 4730 260 34951933
Renal disorder 34.12 26.78 28 4710 25452 34926741
Hepatitis B DNA increased 33.99 26.78 9 4729 556 34951637
Cardiac failure 33.78 26.78 51 4687 91197 34860996
Plasmacytoma 33.16 26.78 14 4724 3677 34948516
Hepatic function abnormal 31.00 26.78 34 4704 44329 34907864
Cytopenia 30.78 26.78 20 4718 12703 34939490
Drug reaction with eosinophilia and systemic symptoms 29.74 26.78 29 4709 32983 34919210
Interstitial lung disease 29.30 26.78 40 4698 65242 34886951
Marasmus 28.83 26.78 8 4730 590 34951603
Fatigue 27.73 26.78 8 4730 370645 34581548
Myelosuppression 27.54 26.78 22 4716 19243 34932950

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 657.39 26.47 359 9040 194305 79540684
Neutrophil count decreased 642.67 26.47 281 9118 93678 79641311
Lymphocyte count decreased 257.69 26.47 121 9278 47168 79687821
White blood cell count decreased 252.58 26.47 195 9204 188093 79546896
Anaemia 185.53 26.47 244 9155 444771 79290218
Plasma cell myeloma 145.71 26.47 86 9313 53173 79681816
Fracture 122.39 26.47 57 9342 21744 79713245
Pneumonia 121.19 26.47 250 9149 659996 79074993
Dementia 112.73 26.47 56 9343 24603 79710386
Thrombocytopenia 92.85 26.47 134 9265 265125 79469864
Tumour lysis syndrome 90.96 26.47 48 9351 23891 79711098
Neutropenia 81.82 26.47 132 9267 287578 79447411
Myelosuppression 79.72 26.47 53 9346 40243 79694746
Bone marrow failure 77.26 26.47 57 9342 51050 79683939
Upper respiratory tract inflammation 74.56 26.47 25 9374 4010 79730979
Neuropathy peripheral 73.75 26.47 87 9312 141218 79593771
Renal disorder 72.90 26.47 51 9348 42054 79692935
Drug ineffective 65.61 26.47 23 9376 1080890 78654099
Plasmacytoma 64.75 26.47 23 9376 4380 79730609
Liver disorder 63.74 26.47 59 9340 72358 79662631
Osteonecrosis of jaw 62.62 26.47 47 9352 43179 79691810
Cytopenia 61.22 26.47 35 9364 20348 79714641
Fatigue 59.52 26.47 18 9381 929709 78805280
Marasmus 57.41 26.47 15 9384 1013 79733976
Cardiac failure 56.68 26.47 80 9319 154762 79580227
Hepatic function abnormal 50.19 26.47 52 9347 73055 79661934
Cardiac amyloidosis 48.78 26.47 15 9384 1825 79733164
Ileus 48.30 26.47 33 9366 26178 79708811
Nephritis allergic 47.35 26.47 12 9387 718 79734271
Pyrexia 47.34 26.47 181 9218 678528 79056461
Rash 46 26.47 161 9238 578197 79156792
Renal impairment 42.86 26.47 71 9328 157712 79577277
Febrile neutropenia 42.66 26.47 88 9311 230911 79504078
Conjunctival irritation 41.72 26.47 8 9391 128 79734861
Hepatitis B DNA increased 41.25 26.47 11 9388 804 79734185
Plasma cell leukaemia 40.82 26.47 13 9386 1773 79733216
Plasma cell myeloma recurrent 40.75 26.47 17 9382 4984 79730005
Delirium 40.66 26.47 50 9349 84577 79650412
Vitiligo 38.70 26.47 13 9386 2096 79732893
Decreased appetite 37.92 26.47 107 9292 342311 79392678
Pain 36.17 26.47 19 9380 703783 79031206
Heat illness 35.04 26.47 9 9390 568 79734421
Genital erythema 34.80 26.47 8 9391 316 79734673
Hyperuricaemia 34.73 26.47 20 9379 11779 79723210
Sepsis 34.65 26.47 89 9310 269339 79465650
Headache 34.56 26.47 17 9382 653755 79081234
Cerebral infarction 34.09 26.47 34 9365 45642 79689347
Drug reaction with eosinophilia and systemic symptoms 32.55 26.47 39 9360 64205 79670784
Dyspnoea 32.48 26.47 32 9367 856993 78877996
Interstitial lung disease 32.36 26.47 52 9347 112548 79622441
Arthralgia 31.55 26.47 14 9385 571789 79163200
Hypercalcaemia 31.28 26.47 30 9369 38400 79696589
Disseminated intravascular coagulation 31.12 26.47 29 9370 35813 79699176
Hypoalbuminaemia 30.48 26.47 23 9376 21274 79713715
Spinal compression fracture 30.41 26.47 21 9378 16937 79718052
Hyperglycaemia 29.73 26.47 39 9360 70296 79664693
C-reactive protein increased 29.72 26.47 54 9345 128973 79606016
Haemoglobin decreased 29.19 26.47 74 9325 222045 79512944
Colon cancer 28.46 26.47 19 9380 14504 79720485
Hypokalaemia 27.89 26.47 56 9343 143984 79591005

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Multiple myeloma indication 109989006 DOID:9538




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 13.41 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4017924 VUID
N0000179099 NUI
D02174 KEGG_DRUG
22690 RXNORM
4017922 VANDF
4017924 VANDF
C0057598 UMLSCUI
CHEBI:4463 CHEBI
CHEBI:41879 CHEBI
DEX PDB_CHEM_ID
CHEMBL1651 ChEMBL_ID
CHEMBL1530428 ChEMBL_ID
DB14649 DRUGBANK_ID
C018038 MESH_SUPPLEMENTAL_RECORD_UI
DWN2WN457X UNII
236702 PUBCHEM_CID
DB01234 DRUGBANK_ID
4552 MMSL
4553 MMSL
6112 MMSL
6848 MMSL
d00206 MMSL
002174 NDDF
002175 NDDF
109070008 SNOMEDCT_US
372584003 SNOMEDCT_US
7561000 SNOMEDCT_US
C0011777 UMLSCUI
816 INN_ID
55812-90-3 SECONDARY_CAS_RN
5743 PUBCHEM_CID
D003907 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None