desflurane indications/contra

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 811 57041-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • desflurane
volatile anesthetic that differs from isoflurane by substitution of a fluorine atom for the chlorine found on the alpha-ethyl component of isoflurane; MF: CF2-O-CFH-CF3; produces anesthetic preconditioning to protect the myocardium against infarction
  • Molecular weight: 168.04
  • Formula: C3H2F6O
  • CLOGP: 1.32
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.68
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 18, 1992 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 159.54 82.61 43 511 16626 3368679
Post procedural complication 136.02 82.61 30 524 4987 3380318
Hyperthermia malignant 97.48 82.61 16 538 538 3384767

Pharmacologic Action:

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SourceCodeDescription
ATC N01AB07 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
CHEBI has role CHEBI:38870 inhalation anaesthetic
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018681 Anesthetics, General
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Cirrhosis of liver contraindication 19943007 DOID:5082
Viral hepatitis C contraindication 50711007 DOID:1883
Viral hepatitis type B contraindication 66071002 DOID:2043
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Neuromyopathy contraindication 255522009 DOID:440
Familial periodic paralysis contraindication 267607008 DOID:1029
Lesion of brain contraindication 301766008
Malignant hyperthermia contraindication 405501007 DOID:8545
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL

External reference:

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IDSource
CHEBI:4445 CHEBI
4020649 VUID
N0000148295 NUI
C0063252 UMLSCUI
7156 IUPHAR_LIGAND_ID
D00546 KEGG_DRUG
4020649 VANDF
N0000148295 NDFRT
N0000007342 NDFRT
d02374 MMSL
4545 MMSL
27340 RXNORM
108393001 SNOMEDCT_US
386841003 SNOMEDCT_US
004114 NDDF
CHEMBL1200733 ChEMBL_ID
CRS35BZ94Q UNII
6505 INN_ID
DB01189 DRUGBANK_ID
C053562 MESH_SUPPLEMENTAL_RECORD_UI
42113 PUBCHEM_CID
DSF PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Desflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6172 LIQUID 240 mL RESPIRATORY (INHALATION) ANDA 18 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 10019-644 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-646 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 52584-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 15 sections