desflurane Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 811 57041-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Difluoromethyl 1,2,2,2-tetrafluoroethyl ether
  • desflurane
A fluorinated ether that is used as a volatile anesthetic for maintenance of general anesthesia.
  • Molecular weight: 168.04
  • Formula: C3H2F6O
  • CLOGP: 1.32
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.68
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 18, 1992 FDA BAXTER HLTHCARE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bradycardia 186.05 86.76 51 623 22518 4615800
Hyperthermia malignant 174.60 86.76 27 647 667 4637651
Post procedural complication 144.82 86.76 32 642 5739 4632579
Cardiac arrest 115.82 86.76 39 635 33968 4604350
Foetal exposure during pregnancy 113.32 86.76 35 639 23134 4615184
Unwanted awareness during anaesthesia 93.58 86.76 13 661 146 4638172

Pharmacologic Action:

SourceCodeDescription
ATC N01AB07 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Halogenated hydrocarbons
FDA PE N0000175975 General Anesthesia
FDA EPC N0000175681 General Anesthetic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
General anesthesia indication 50697003
Hyperkalemia contraindication 14140009
Cirrhosis of liver contraindication 19943007 DOID:5082
Viral hepatitis C contraindication 50711007 DOID:1883
Viral hepatitis type B contraindication 66071002 DOID:2043
Benign intracranial hypertension contraindication 68267002 DOID:11459
Duchenne muscular dystrophy contraindication 76670001 DOID:11723
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Neuromyopathy contraindication 255522009 DOID:440
Familial periodic paralysis contraindication 267607008 DOID:1029
Lesion of brain contraindication 301766008
Malignant hyperthermia contraindication 405501007
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glycine receptor (alpha-1/beta) Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
GABA-A receptor; anion channel Ion channel POSITIVE ALLOSTERIC MODULATOR CHEMBL CHEMBL
Potassium channel subfamily K member 10 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 18 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 3 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 9 Ion channel OPENER CHEMBL CHEMBL
Potassium channel subfamily K member 2 Ion channel OPENER CHEMBL CHEMBL

External reference:

IDSource
D000077335 MESH_DESCRIPTOR_UI
4020649 VUID
N0000148295 NUI
C0063252 UMLSCUI
D00546 KEGG_DRUG
108393001 SNOMEDCT_US
247482 MMSL
4020649 VANDF
d02374 MMSL
4545 MMSL
27340 RXNORM
386841003 SNOMEDCT_US
004114 NDDF
CRS35BZ94Q UNII
6505 INN_ID
42113 PUBCHEM_CID
CHEBI:4445 CHEBI
CHEMBL1200733 ChEMBL_ID
DSF PDB_CHEM_ID
DB01189 DRUGBANK_ID
7156 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Desflurane HUMAN PRESCRIPTION DRUG LABEL 1 0781-6172 LIQUID 240 mL RESPIRATORY (INHALATION) ANDA 18 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 10019-644 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
SUPRANE HUMAN PRESCRIPTION DRUG LABEL 1 10019-646 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 18 sections
Suprane HUMAN PRESCRIPTION DRUG LABEL 1 52584-641 LIQUID 240 mL RESPIRATORY (INHALATION) NDA 15 sections