deptropine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 808 604-51-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • deptropine
  • dibenzheptropine
  • deptropine citrate
minor descriptor (65-85); on-line & Index Medicus search TROPANES (66-85); RN given refers to parent cpd
  • Molecular weight: 333.48
  • Formula: C23H27NO
  • CLOGP: 4.21
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.75
  • ROTB: 2

Drug dosage:

DoseUnitRoute
2 mg O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R06AX16 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50370 parasympatholytics

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine-binding protein Unclassified Ki 5.70 CHEMBL
Soluble acetylcholine receptor Unclassified Ki 5.20 CHEMBL

External reference:

IDSource
D07404 KEGG_DRUG
C0057763 UMLSCUI
CHEBI:50189 CHEBI
CHEMBL1946186 ChEMBL_ID
DB13466 DRUGBANK_ID
C100220 MESH_SUPPLEMENTAL_RECORD_UI
203911 PUBCHEM_CID
1331 INN_ID
2169-75-7 SECONDARY_CAS_RN
AY31301GKG UNII
CHEMBL2107603 ChEMBL_ID

Pharmaceutical products:

None