demecarium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 801 56-94-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • demecarium bromide
  • demecarium
  • demekarium bromide
  • demekastigmine bromide
major descriptor (65-85); on-line search AMMONIUM COMPOUNDS (66-85); Index Medicus search DEMECARIUM BROMIDE (65-85)
  • Molecular weight: 556.79
  • Formula: C32H52N4O4
  • CLOGP: -2.09
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 0
  • TPSA: 59.08
  • ALOGS: -7.57
  • ROTB: 17

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 ml None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 5, 1959 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01EB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Parasympathomimetics
CHEBI has role CHEBI:37733 EC 3.1.1.8 inhibitor
CHEBI has role CHEBI:38462 acetylcholinesterase inhibitors
MeSH PA D018678 Cholinergic Agents
MeSH PA D002800 Cholinesterase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholinesterase Enzyme INHIBITOR DRUGBANK CHEMBL

External reference:

IDSource
4017960 VUID
N0000179097 NUI
D00667 KEGG_DRUG
107771 RXNORM
4017960 VANDF
4019706 VANDF
C0360174 UMLSCUI
CHEBI:4391 CHEBI
CHEMBL1201229 ChEMBL_ID
CHEMBL1200514 ChEMBL_ID
DB00944 DRUGBANK_ID
C100193 MESH_SUPPLEMENTAL_RECORD_UI
ILP8XJ8R5K UNII
5966 PUBCHEM_CID
4542 MMSL
001710 NDDF
372827003 SNOMEDCT_US
49145008 SNOMEDCT_US
70934008 SNOMEDCT_US
769 INN_ID
16505-84-3 SECONDARY_CAS_RN

Pharmaceutical products:

None