delorazepam Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 800 2894-67-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • delorazepam
  • chlordemethyldiazepam
  • chlordesmethyldiazepam
  • chlorodesmethyldiazepam
  • Molecular weight: 305.16
  • Formula: C15H10Cl2N2O
  • CLOGP: 3.08
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 41.46
  • ALOGS: -4.68
  • ROTB: 1

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1623.12 244.50 289 275 27658 4610770
Sopor 1580.04 244.50 233 331 6293 4632135
Intentional self-injury 1050.77 244.50 168 396 7215 4631213

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.52 acidic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel IC50 8.75 WOMBAT-PK
GABA-A receptor; anion channel Ion channel IC50 8.55 CHEMBL

External reference:

IDSource
D07784 KEGG_DRUG
CHEBI:135295 CHEBI
CHEMBL268254 ChEMBL_ID
C013434 MESH_SUPPLEMENTAL_RECORD_UI
O91W32476G UNII
4510 INN_ID
DB01511 DRUGBANK_ID
17925 PUBCHEM_CID

Pharmaceutical products:

None