All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

delorazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	800	2894-67-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: delorazepam chlordemethyldiazepam chlordesmethyldiazepam chlorodesmethyldiazepam	Molecular weight: 305.16 Formula: C15H10Cl2N2O CLOGP: 3.08 LIPINSKI: 0 HAC: 3 HDO: 1 TPSA: 41.46 ALOGS: -4.68 ROTB: 1

Drug dosage:

None

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.28 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	2.20 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.17 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.05 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	200 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	1550.99	56.39	417	3078	72101	63413426
Sopor	1433.22	56.39	312	3183	21852	63463675
Intentional self-injury	807.57	56.39	202	3293	25485	63460042
Intentional overdose	199.80	56.39	92	3403	74060	63411467
Suicide attempt	168.44	56.39	77	3418	60841	63424686
Bradyphrenia	151.09	56.39	41	3454	6939	63478588
Poisoning	131.87	56.39	43	3452	13657	63471870
Toxicity to various agents	106.13	56.39	96	3399	247154	63238373
Intentional product misuse	91.49	56.39	51	3444	60866	63424661
Substance abuse	89.06	56.39	25	3470	4782	63480745
Coma	75.73	56.39	46	3449	64318	63421209
Overdose	74.93	56.39	57	3438	115021	63370506
Bradykinesia	65.32	56.39	20	3475	5168	63480359
Confusional state	62.97	56.39	71	3424	236309	63249218
Tachycardia	62.90	56.39	52	3443	118104	63367423
Psychomotor hyperactivity	58.38	56.39	22	3473	10641	63474886
Sluggishness	56.64	56.39	18	3477	5251	63480276

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	901.45	58.64	191	1716	11945	34943079
Drug abuse	457.47	58.64	178	1729	98918	34856106
Intentional self-injury	300.58	58.64	81	1826	13690	34941334
Bradyphrenia	103.30	58.64	28	1879	4770	34950254
Toxicity to various agents	91.44	58.64	80	1827	200282	34754742
Respiratory depression	80.32	58.64	31	1876	16214	34938810
Bradykinesia	66.69	58.64	19	1888	3874	34951150
Drug interaction	66.56	58.64	71	1836	225875	34729149
Intentional overdose	61.72	58.64	35	1872	43639	34911385

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sopor	2221.48	54.89	498	4887	32512	79706491
Drug abuse	1750.51	54.89	577	4808	162114	79576889
Intentional self-injury	1092.74	54.89	281	5104	32138	79706865
Bradyphrenia	242.55	54.89	68	5317	10572	79728431
Intentional overdose	229.55	54.89	121	5264	105839	79633164
Suicide attempt	191.77	54.89	99	5286	82833	79656170
Toxicity to various agents	173.30	54.89	175	5210	421365	79317638
Bradykinesia	115.64	54.89	36	5349	8007	79730996
Psychomotor hyperactivity	103.67	54.89	40	5345	16809	79722194
Intentional product misuse	101.58	54.89	69	5316	95096	79643907
Overdose	95.18	54.89	87	5298	184119	79554884
Poisoning	94.39	54.89	42	5343	25230	79713773
Substance abuse	83.07	54.89	30	5355	10496	79728507
Confusional state	82.18	54.89	104	5281	317893	79421110
Coma	82.15	54.89	62	5323	100587	79638416
Sedation	81.31	54.89	48	5337	51847	79687156
Sluggishness	76.28	54.89	25	5360	6547	79732456
Drug interaction	71.82	54.89	112	5273	415071	79323932
Confabulation	64.49	54.89	13	5372	485	79738518
Somnolence	61.39	54.89	78	5307	238903	79500100
Respiratory depression	58.06	54.89	31	5354	27599	79711404
Tachycardia	57.06	54.89	65	5320	177703	79561300

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000927	Anticonvulsants
MeSH PA	D002491	Central Nervous System Agents
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35623	anticonvulsants
CHEBI has role	CHEBI:35717	hypnotics
CHEBI has role	CHEBI:50268	GABA modulators
CHEBI has role	CHEBI:77746	Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.52	acidic
pKa2	2.23	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN		IC50	8.75		WOMBAT-PK
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN		IC50	8.55		CHEMBL

External reference:

ID	Source
D07784	KEGG_DRUG
C0055353	UMLSCUI
CHEBI:135295	CHEBI
CHEMBL268254	ChEMBL_ID
DB01511	DRUGBANK_ID
17925	PUBCHEM_CID
C013434	MESH_SUPPLEMENTAL_RECORD_UI
4510	INN_ID
O91W32476G	UNII

Pharmaceutical products:

None