aclarubicin indications/contra

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 80 57576-44-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aclacinomycin
  • Aclacinomycin A
  • aclacur
  • aclarubicin
  • Antibiotic 3082A
  • aclarubicin hydrochloride
  • aclarubicin HCl
An anthracycline produced by Streptomyces galilaeus. It has potent antineoplastic activity.
  • Molecular weight: 811.88
  • Formula: C42H53NO15
  • CLOGP: 3.43
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 4
  • TPSA: 217.05
  • ALOGS: -3.57
  • ROTB: 10

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Bone marrow failure 246.25 127.60 39 51 8448 3377321

Pharmacologic Action:

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SourceCodeDescription
ATC L01DB04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.01 acidic
pKa2 9.34 acidic
pKa3 8.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 6.15 DRUG MATRIX
72 kDa type IV collagenase Enzyme IC50 5 CHEMBL

External reference:

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IDSource
N0000168464 NUI
C0001143 UMLSCUI
D01911 KEGG_DRUG
501948RI66 UNII
75443-99-1 SECONDARY_CAS_RN
4945 INN_ID
391713006 SNOMEDCT_US
N0000168464 NDFRT
003919 NDDF
239 RXNORM
326830005 SNOMEDCT_US
CHEMBL502620 ChEMBL_ID
C011157 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL1697719 ChEMBL_ID
451415 PUBCHEM_CID
D015250 MESH_DESCRIPTOR_UI
DB11617 DRUGBANK_ID
CHEBI:31171 CHEBI

Pharmaceutical products:

None