dehydrocholic acid indications/contra

Stem definitionDrug idCAS RN
794 81-23-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dehydrocholic acid
  • cholepatin
  • decholin
  • dehystolin
  • ketocholanic acid
  • oxycholin
A semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid.
  • Molecular weight: 402.53
  • Formula: C24H34O5
  • CLOGP: 2.23
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 88.51
  • ALOGS: -4.76
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D002756 Cholagogues and Choleretics
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:55324 gastrointestinal drug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Disorder of biliary tract indication 105997008 DOID:9741
Incomplete passage of stool indication 249515001
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal obstruction contraindication 126765001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.64 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
4018426 VUID
N0000146752 NUI
C0011182 UMLSCUI
D01693 KEGG_DRUG
4018426 VANDF
N0000007086 NDFRT
N0000146752 NDFRT
001203 NDDF
001207 NDDF
51752005 SNOMEDCT_US
857 MMSL
3141 RXNORM
387285003 SNOMEDCT_US
4540 MMSL
d01030 MMSL
6674 PUBCHEM_CID
CHEMBL514446 ChEMBL_ID
D003685 MESH_DESCRIPTOR_UI
NH5000009I UNII
157 INN_ID
DB11622 DRUGBANK_ID
CHEBI:31459 CHEBI

Pharmaceutical products:

None