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decamethonium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 789 | 156-74-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 21, 1975 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D009465 | Neuromuscular Agents |
| MeSH PA | D009466 | Neuromuscular Blocking Agents |
| MeSH PA | D009467 | Neuromuscular Depolarizing Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| CHEBI has role | CHEBI:47958 | nicotinic acetylcholine receptor agonist |
| CHEBI has role | CHEBI:51371 | muscle relaxant |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscle-type nicotinic acetylcholine receptor | Ion channel | PARTIAL AGONIST | CHEMBL | CHEMBL | |||||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 7.60 | PDSP | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.23 | CHEMBL | |||||
| Histamine H3 receptor | GPCR | IC50 | 6.09 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | Ki | 5.46 | CHEMBL | |||||
| Neuronal acetylcholine receptor; alpha4/beta2 | Ion channel | Ki | 5.24 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0057231 | UMLSCUI |
| CHEBI:41934 | CHEBI |
| CHEMBL1190 | ChEMBL_ID |
| DB01245 | DRUGBANK_ID |
| CHEMBL1134 | ChEMBL_ID |
| C033019 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2968 | PUBCHEM_CID |
| 541-22-0 | SECONDARY_CAS_RN |
| C1CG1S3T2W | UNII |
| 002403 | NDDF |
| 004957 | NDDF |
| 39514001 | SNOMEDCT_US |
| DME | PDB_CHEM_ID |
| 1397 | INN_ID |
| C1CG1S3T2W | INXIGHT DRUGS |
Pharmaceutical products:
None