cytarabine ocfosfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
arabinofuranosyl derivatives 771 73532-83-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cytarabine ocfosate
  • fosteabine
  • cytarabine ocfosfate
  • cytarabine ocfosphate hydrate
  • fosteabine sodium monohydrate
  • starasid
  • Molecular weight: 575.68
  • Formula: C27H50N3O8P
  • CLOGP: 6.08
  • LIPINSKI: 3
  • HAC: 11
  • HDO: 4
  • TPSA: 164.14
  • ALOGS: -5.04
  • ROTB: 22
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 20 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 56
kinase-selectivity-class AXL,CDK4,CDK9,EPHB4,ERBB2,GRK2,MAP2K6,MAPK7,STK33,SYK,TEK,ZAP70 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000998 Antiviral Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:233423 antifibrotic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.84 acidic
pKa2 11.57 acidic
pKa3 13.08 acidic
pKa4 4.04 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
65093-40-5 SECONDARY_CAS_RN
3041 RXNORM
C0089089 UMLSCUI
AR3 PDB_CHEM_ID
C061162 MESH_SUPPLEMENTAL_RECORD_UI
3I7U8R8NWC UNII
23671562 PUBCHEM_CID
372 MMSL
4526 MMSL
d00201 MMSL
002649 NDDF
387511003 SNOMEDCT_US
89265009 SNOMEDCT_US
C0010711 UMLSCUI
CHEBI:135838 CHEBI
DB00987 DRUGBANK_ID
6253 PUBCHEM_CID
1709 INN_ID
4018080 VANDF
D003561 MESH_DESCRIPTOR_UI
CHEBI:28680 CHEBI

Pharmaceutical products:

None