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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
cyclothiazide 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
diuretics, chlorothiazide derivatives
761
2259-96-3
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
cyclothiazide
ciclotiazide
inhibits the desensitization of AMPA-type receptors; structure
Molecular weight: 389.87
Formula: C14H16ClN3O4S2
CLOGP: 1.98
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 118.36
ALOGS: -3.15
ROTB: 2
Status: OFM
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
Dose
Unit
Route
5
mg
O
5
mg
O
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Bocci G, Oprea TI, Benet LZ
S (Water solubility)
0.28 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
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Date
Agency
Company
Orphan
June 8, 1982
FDA
PHARMACIA AND UPJOHN
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
C03AA09
CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides, plain
ATC
C03AB09
CARDIOVASCULAR SYSTEM
DIURETICS
LOW-CEILING DIURETICS, THIAZIDES
Thiazides and potassium in combination
CHEBI has role
CHEBI:35498
diuretics
CHEBI has role
CHEBI:35674
antihypertensive drugs
MeSH PA
D000959
Antihypertensive Agents
MeSH PA
D002317
Cardiovascular Agents
MeSH PA
D004232
Diuretics
MeSH PA
D045283
Natriuretic Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.89
acidic
pKa2
11.0
acidic
pKa3
1.34
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Solute carrier family 12 member 3
Transporter
P55017
S12A3_HUMAN
INHIBITOR
CHEMBL
CHEMBL
Glutamate receptor 1
Ion channel
P42261
GRIA1_HUMAN
EC50
5.70
CHEMBL
Glutamate receptor 2
Ion channel
P42262
GRIA2_HUMAN
EC50
5.65
CHEMBL
Glutamate receptor 4
Ion channel
P48058
GRIA4_HUMAN
ALLOSTERIC MODULATOR
EC50
5.41
IUPHAR
Glutamate receptor 3
Ion channel
P42263
GRIA3_HUMAN
ALLOSTERIC MODULATOR
EC50
4.86
IUPHAR
Glutamate receptor ionotropic, AMPA
Ion channel
GRIA1_RAT
GRIA2_RAT
GRIA3_RAT
GRIA4_RAT
IC50
5.21
CHEMBL
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External reference:
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ID
Source
CYZ
PDB_CHEM_ID
002304
NDDF
1138
INN_ID
22033
RXNORM
2910
PUBCHEM_CID
37006008
SNOMEDCT_US
4017504
VUID
4017504
VANDF
4167
IUPHAR_LIGAND_ID
C004639
MESH_SUPPLEMENTAL_RECORD_UI
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Pharmaceutical products:
None
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Structure 🔎
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cyclothiazide