acipimox indications/contra

Stem definitionDrug idCAS RN
76 51037-30-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acipimox
  • olbemox
  • olbetam
  • methylpyrazinecarboxylic acid 4-oxide
lipolysis inhibitor
  • Molecular weight: 154.13
  • Formula: C6H6N2O3
  • CLOGP: -0.16
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 75.65
  • ALOGS: -1.11
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.50 g O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C10AD06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Nicotinic acid and derivatives
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hyperlipoproteinemia indication 3744001 DOID:1168

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.88 acidic
pKa2 1.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Hydroxycarboxylic acid receptor 2 GPCR AGONIST EC50 5.60 IUPHAR SCIENTIFIC LITERATURE

External reference:

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IDSource
1596 IUPHAR_LIGAND_ID
C0050558 UMLSCUI
D07190 KEGG_DRUG
16817 RXNORM
319982006 SNOMEDCT_US
391711008 SNOMEDCT_US
003918 NDDF
CHEMBL345714 ChEMBL_ID
DB09055 DRUGBANK_ID
K9AY9IR2SD UNII
3809 INN_ID
C027696 MESH_SUPPLEMENTAL_RECORD_UI
5310993 PUBCHEM_CID

Pharmaceutical products:

None