acipimox 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antacids, aluminium derivatives 76 51037-30-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acipimox
  • olbemox
  • olbetam
  • methylpyrazinecarboxylic acid 4-oxide
lipolysis inhibitor
  • Molecular weight: 154.13
  • Formula: C6H6N2O3
  • CLOGP: 0.28
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 75.65
  • ALOGS: -1.11
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AD06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Nicotinic acid and derivatives
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hyperlipoproteinemia indication 3744001 DOID:1168




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.88 acidic
pKa2 1.75 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Hydroxycarboxylic acid receptor 2 GPCR AGONIST EC50 5.60 IUPHAR SCIENTIFIC LITERATURE

External reference:

IDSource
D07190 KEGG_DRUG
16817 RXNORM
C0050558 UMLSCUI
CHEBI:94688 CHEBI
CHEMBL345714 ChEMBL_ID
DB09055 DRUGBANK_ID
5310993 PUBCHEM_CID
3809 INN_ID
C027696 MESH_SUPPLEMENTAL_RECORD_UI
1596 IUPHAR_LIGAND_ID
K9AY9IR2SD UNII
319982006 SNOMEDCT_US
391711008 SNOMEDCT_US
003918 NDDF

Pharmaceutical products:

None