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crotamiton 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 744 | 483-63-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
antiscabies, antipruritic drug; active ingredient in Eurax Cream & Lotion (Geigy); request from searcher 3/76; structure
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PRKDC,STK33,TEK | 21 | |||
| kinase-selectivity-class | AXL,BRAF,DDR1,EPHB4,ERBB2,GRK2,PDK4,SIK2,SIK3 | 9 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 6, 1949 | FDA | RANBAXY |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Skin burning sensation | 43.18 | 42.49 | 12 | 558 | 19599 | 90608278 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatic function abnormal | 47.94 | 31.95 | 22 | 1173 | 89273 | 110498831 |
| Skin burning sensation | 35.45 | 31.95 | 12 | 1183 | 21813 | 110566291 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D010575 | Pesticides |
| CHEBI has role | CHEBI:59683 | antipruritic drug |
| CHEBI has role | CHEBI:73333 | scabicide |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infestation by Sarcoptes scabiei var hominis | indication | 128869009 | DOID:8295 |
| Itching of skin | indication | 418363000 | |
| Denuded skin | contraindication | 418242004 | |
| Inflammatory dermatosis | contraindication | 703938007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4018661 | VUID |
| N0000146972 | NUI |
| D01381 | KEGG_DRUG |
| 21766 | RXNORM |
| C0056519 | UMLSCUI |
| CHEBI:31439 | CHEBI |
| CHEMBL6067975 | ChEMBL_ID |
| DB00265 | DRUGBANK_ID |
| 2883 | PUBCHEM_CID |
| C005553 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11165 | IUPHAR_LIGAND_ID |
| 673 | INN_ID |
| D6S4O4XD0H | UNII |
| 4511 | MMSL |
| 002993 | NDDF |
| 387515007 | SNOMEDCT_US |
| 89692007 | SNOMEDCT_US |
| 4018661 | VANDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Crotan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0682-0051 | LOTION | 100 mg | TOPICAL | ANDA | 19 sections |
| Eurax | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69489-311 | CREAM | 100 mg | TOPICAL | NDA | 19 sections |
| Pruradik | HUMAN PRESCRIPTION DRUG LABEL | 1 | 73352-051 | LOTION | 100 mg | TOPICAL | ANDA | 18 sections |