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cotinine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 737 | 486-56-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 97 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.10 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.89 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 17 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 1000 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,PDK1,PDK2,PDK4,PRKDC | 13 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,GRK2 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D007202 | Indicators and Reagents |
| CHEBI has role | CHEBI:35469 | antidepressant |
| CHEBI has role | CHEBI:59163 | biomarker |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:76967 | human xenobiotic metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.78 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Neuronal acetylcholine receptor subunit alpha-2 | Ion channel | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D03596 | KEGG_DRUG |
| C0010194 | UMLSCUI |
| CHEBI:68641 | CHEBI |
| CHEMBL578211 | ChEMBL_ID |
| CHEMBL3989573 | ChEMBL_ID |
| D003367 | MESH_DESCRIPTOR_UI |
| 854019 | PUBCHEM_CID |
| 1625 | INN_ID |
| 5695-98-7 | SECONDARY_CAS_RN |
| K5161X06LL | UNII |
| 115620009 | SNOMEDCT_US |
| U5H | PDB_CHEM_ID |
| K5161X06LL | INXIGHT DRUGS |
Pharmaceutical products:
None