cortisone acetate ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 734 50-04-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cortisone acetate
  • cortone acetate
  • irisone acetate
  • adrenalex
A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
  • Molecular weight: 402.49
  • Formula: C23H30O6
  • CLOGP: 2.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 97.74
  • ALOGS: -4.16
  • ROTB: 4

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.28 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.87 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 13, 1950 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3758.07 69.05 3023 123256 180703 63182040
Systemic lupus erythematosus 3529.49 69.05 3078 123201 205840 63156903
Glossodynia 3325.02 69.05 2785 123494 176091 63186652
Hand deformity 3106.61 69.05 2552 123727 156905 63205838
Wound 2956.56 69.05 2505 123774 160758 63201985
Pericarditis 2491.90 69.05 2073 124206 129506 63233237
Abdominal discomfort 2445.92 69.05 3090 123189 317795 63044948
Alopecia 2379.50 69.05 3127 123152 334409 63028334
Discomfort 2324.07 69.05 2212 124067 165162 63197581
Swelling 2321.68 69.05 2791 123488 272587 63090156
Anti-cyclic citrullinated peptide antibody positive 2222.67 69.05 1842 124437 114370 63248373
Arthropathy 2165.96 69.05 2493 123786 232299 63130444
Contraindicated product administered 1991.56 69.05 2302 123977 215346 63147397
Synovitis 1903.94 69.05 2091 124188 184827 63177916
Maternal exposure during pregnancy 1745.67 69.05 2165 124114 217897 63144846
Rheumatoid factor positive 1618.83 69.05 1341 124938 83065 63279678
Infusion related reaction 1515.23 69.05 2136 124143 243385 63119358
Hepatic enzyme increased 1454.10 69.05 1896 124383 200432 63162311
Duodenal ulcer perforation 1452.63 69.05 1278 125001 85931 63276812
Helicobacter infection 1363.08 69.05 1267 125012 91518 63271225
Product use issue 1348.81 69.05 1911 124368 218609 63144134
Hypersensitivity 1249.62 69.05 2149 124130 290536 63072207
Drug intolerance 1180.74 69.05 2160 124119 306501 63056242
Treatment failure 1097.30 69.05 1643 124636 197400 63165343
Rheumatic fever 940.17 69.05 739 125540 42372 63320371
Swollen joint count increased 849.23 69.05 647 125632 35407 63327336
Joint swelling 846.69 69.05 1951 124328 325715 63037028
Pain 760.51 69.05 3191 123088 737437 62625306
Therapeutic product effect decreased 749.56 69.05 1362 124917 191825 63170918
Type 2 diabetes mellitus 660.97 69.05 722 125557 63146 63299597
Blood cholesterol increased 647.04 69.05 864 125415 93168 63269575
Blister 639.05 69.05 1018 125261 128796 63233947
Death 630.13 69.05 27 126252 374354 62988389
Fall 617.79 69.05 42 126237 392292 62970451
Hip arthroplasty 606.79 69.05 602 125677 47044 63315699
Rash 600.98 69.05 2451 123828 558420 62804323
Anaemia 494.07 69.05 21 126258 293409 63069334
Knee arthroplasty 492.85 69.05 573 125706 53633 63309110
Folliculitis 486.43 69.05 648 125631 69669 63293074
General physical health deterioration 479.46 69.05 1163 125116 200239 63162504
Toxicity to various agents 469.48 69.05 4 126275 247246 63115497
Muscle injury 457.85 69.05 606 125673 64739 63298004
Musculoskeletal stiffness 430.70 69.05 1058 125221 183560 63179183
Irritable bowel syndrome 425.59 69.05 661 125618 81751 63280992
Intentional product use issue 415.60 69.05 837 125442 127055 63235688
Hypotension 415.08 69.05 34 126245 272570 63090173
Sleep disorder due to general medical condition, insomnia type 406.12 69.05 510 125769 51707 63311036
Urinary tract infection 403.02 69.05 33 126246 264651 63098092
Nausea 400.80 69.05 680 125599 853791 62508952
Liver injury 394.61 69.05 542 125737 59978 63302765
Drug interaction 386.92 69.05 16 126263 229115 63133628
Constipation 382.22 69.05 15 126264 224928 63137815
Impaired healing 358.31 69.05 692 125587 101850 63260893
Back pain 347.14 69.05 55 126224 264090 63098653
Neutropenia 314.20 69.05 7 126272 174998 63187745
Somnolence 313.79 69.05 9 126270 178676 63184067
Cough 298.31 69.05 105 126174 292638 63070105
Diarrhoea 297.15 69.05 612 125667 714754 62647989
Dehydration 296.35 69.05 11 126268 173343 63189400
Psoriatic arthropathy 284.14 69.05 588 125691 90932 63271811
Sepsis 267.79 69.05 8 126271 153115 63209628
Erythema 264.40 69.05 23 126256 175728 63187015
Product dose omission issue 263.96 69.05 70 126209 234243 63128500
Ill-defined disorder 262.92 69.05 533 125746 81222 63281521
Fatigue 257.86 69.05 2794 123485 885234 62477509
Drug ineffective 255.90 69.05 3180 123099 1041585 62321158
Fibromyalgia 255.89 69.05 522 125757 79898 63282845
Injury 255.38 69.05 494 125785 72753 63289990
Prescribed overdose 247.24 69.05 322 125957 33831 63328912
Feeling abnormal 245.04 69.05 12 126267 148380 63214363
Seizure 243.32 69.05 4 126275 132630 63230113
Haemoglobin decreased 239.48 69.05 12 126267 145473 63217270
Blood pressure increased 236.35 69.05 24 126255 162038 63200705
Tremor 234.60 69.05 6 126273 132233 63230510
Live birth 231.27 69.05 270 126009 25360 63337383
White blood cell count decreased 224.20 69.05 13 126266 139091 63223652
Disease progression 223.95 69.05 4 126275 122754 63239989
Asthenia 219.80 69.05 264 126015 383340 62979403
Febrile neutropenia 215.50 69.05 4 126275 118445 63244298
Thrombocytopenia 213.77 69.05 25 126254 151132 63211611
Condition aggravated 210.42 69.05 1444 124835 400773 62961970
Adverse event 209.56 69.05 434 125845 67125 63295618
Mobility decreased 208.40 69.05 621 125658 120538 63242205
Pneumonia 207.29 69.05 370 125909 456397 62906346
Platelet count decreased 207.00 69.05 5 126274 116117 63246626
Neuropathy peripheral 202.22 69.05 5 126274 113662 63249081
Renal failure 199.20 69.05 8 126271 117644 63245099
Myalgia 195.80 69.05 29 126250 146500 63216243
Injection site pain 195.16 69.05 17 126262 129783 63232960
Dyspnoea 190.99 69.05 676 125603 660637 62702106
Stomatitis 190.36 69.05 658 125621 138067 63224676
Pulmonary embolism 187.74 69.05 11 126268 116673 63246070
Cerebrovascular accident 187.56 69.05 6 126273 108018 63254725
Syncope 186.05 69.05 12 126267 117373 63245370
Respiratory failure 183.05 69.05 4 126275 101854 63260889
Pancytopenia 177.45 69.05 3 126276 96930 63265813
Alanine aminotransferase increased 175.87 69.05 7 126272 103763 63258980
Chills 175.59 69.05 13 126266 113365 63249378
Myocardial infarction 171.83 69.05 6 126273 99887 63262856
Lower respiratory tract infection 164.78 69.05 608 125671 131699 63231044
Palpitations 163.61 69.05 17 126262 112753 63249990
Hyperhidrosis 162.44 69.05 14 126265 107822 63254921
Cardiac failure 162.19 69.05 3 126276 89139 63273604
Blood creatinine increased 159.64 69.05 3 126276 87841 63274902
Aspartate aminotransferase increased 156.78 69.05 5 126274 90272 63272471
COVID-19 156.72 69.05 20 126259 113083 63249660
Anxiety 156.62 69.05 122 126157 217419 63145324
Adjustment disorder with depressed mood 154.60 69.05 142 126137 10062 63352681
Vision blurred 153.12 69.05 7 126272 91917 63270826
Renal impairment 153.06 69.05 5 126274 88350 63274393
Deep vein thrombosis postoperative 152.72 69.05 148 126131 11221 63351522
Drug tolerance decreased 152.53 69.05 181 126098 17292 63345451
Infection 151.47 69.05 874 125405 228299 63134444
Heart rate increased 151.24 69.05 9 126270 94229 63268514
Lip dry 148.01 69.05 168 126111 15302 63347441
Foot deformity 147.26 69.05 226 126053 27627 63335116
Vomiting 146.48 69.05 595 125684 559022 62803721
Facet joint syndrome 146.38 69.05 149 126130 11989 63350754
Balance disorder 145.45 69.05 5 126274 84417 63278326
Cellulitis 144.28 69.05 4 126275 81954 63280789
Loss of consciousness 143.36 69.05 30 126249 118091 63244652
Chest discomfort 141.84 69.05 24 126255 109945 63252798
Oropharyngeal pain 140.33 69.05 13 126266 94474 63268269
Dislocation of vertebra 140.33 69.05 125 126154 8510 63354233
Injection site erythema 139.63 69.05 6 126273 83168 63279575
Retinitis 138.79 69.05 108 126171 6088 63356655
Adverse drug reaction 138.34 69.05 410 125869 79304 63283439
Inappropriate schedule of product administration 137.89 69.05 21 126258 103944 63258799
Oxygen saturation decreased 137.61 69.05 10 126269 88575 63274168
Dysphagia 137.61 69.05 10 126269 88575 63274168
Malignant neoplasm progression 137.61 69.05 6 126273 82115 63280628
Deep vein thrombosis 137.59 69.05 7 126272 83793 63278950
Influenza 135.31 69.05 26 126253 108696 63254047
Blood glucose increased 134.40 69.05 8 126271 83748 63278995
Leukopenia 131.69 69.05 5 126274 77285 63285458
Tachycardia 131.63 69.05 36 126243 118120 63244623
Prescribed underdose 131.15 69.05 222 126057 29467 63333276
Anti-cyclic citrullinated peptide antibody 130.53 69.05 108 126171 6650 63356093
Weight decreased 130.10 69.05 219 126060 276579 63086164
Herpes zoster 128.99 69.05 9 126270 82453 63280290
Overdose 128.31 69.05 35 126244 115043 63247700
Abdominal pain 128.20 69.05 243 126036 293213 63069530
Flushing 127.45 69.05 5 126274 75082 63287661
Bradycardia 127.35 69.05 4 126275 73223 63289520
Grip strength decreased 126.59 69.05 187 126092 22100 63340643
Exposure during pregnancy 125.68 69.05 627 125652 154920 63207823
Bronchitis 121.73 69.05 48 126231 124887 63237856
Gastrointestinal disorder 121.26 69.05 550 125729 130689 63232054
Stress 119.27 69.05 3 126276 67164 63295579
Anaphylactic reaction 117.20 69.05 3 126276 66097 63296646
Epistaxis 116.53 69.05 7 126272 72718 63290025
Peripheral venous disease 115.23 69.05 148 126131 15329 63347414
Coma 113.82 69.05 3 126276 64361 63298382
Insomnia 111.93 69.05 159 126120 215093 63147650
Autoimmune disorder 110.61 69.05 153 126126 17024 63345719
Hypokalaemia 109.46 69.05 35 126244 103769 63258974
Interstitial lung disease 109.05 69.05 3 126276 61905 63300838
Nerve injury 109.00 69.05 116 126163 9830 63352913
Gastrooesophageal reflux disease 108.68 69.05 28 126251 95611 63267132
Blood pressure decreased 108.13 69.05 5 126274 65017 63297726
Dizziness 108.06 69.05 464 125815 429461 62933282
Suicide attempt 107.13 69.05 3 126276 60915 63301828
Chronic obstructive pulmonary disease 106.98 69.05 4 126275 62682 63300061
Depression 106.32 69.05 141 126138 196351 63166392
Rash pruritic 104.95 69.05 3 126276 59796 63302947
Swelling face 102.03 69.05 6 126273 63469 63299274
Hypoglycaemia 98.65 69.05 5 126274 60060 63302683
X-ray abnormal 98.60 69.05 100 126179 8010 63354733
Lupus vulgaris 97.86 69.05 87 126192 5907 63356836
Nasal congestion 97.58 69.05 9 126270 65651 63297092
Rhinorrhoea 94.81 69.05 10 126269 65567 63297176
Suicidal ideation 94.27 69.05 8 126271 62413 63300330
Lethargy 94.14 69.05 4 126275 56003 63306740
Pulmonary fibrosis 93.47 69.05 229 126050 39580 63323163
Thrombosis 93.30 69.05 10 126269 64745 63297998
Dry skin 92.60 69.05 5 126274 56882 63305861
Systemic lupus erythematosus rash 92.48 69.05 57 126222 2195 63360548
Abdominal distension 89.92 69.05 30 126249 86585 63276158
Haematochezia 89.41 69.05 4 126275 53540 63309203
Hot flush 88.22 69.05 3 126276 51156 63311587
Cardiac disorder 87.56 69.05 3 126276 50813 63311930
Pleural effusion 87.25 69.05 38 126241 93172 63269571
Cystitis 86.00 69.05 6 126273 54985 63307758
Hallucination 85.67 69.05 6 126273 54811 63307932
Productive cough 85.58 69.05 12 126267 63196 63299547
Joint range of motion decreased 85.31 69.05 195 126084 32233 63330510
Breast cancer 82.86 69.05 3 126276 48380 63314363
Liver function test abnormal 82.47 69.05 3 126276 48178 63314565
Unevaluable event 82.16 69.05 5 126274 51381 63311362
Angioedema 82.06 69.05 3 126276 47962 63314781
Cataract 81.71 69.05 9 126270 57044 63305699
Multiple organ dysfunction syndrome 81.16 69.05 9 126270 56743 63306000
Contusion 80.69 69.05 543 125736 149501 63213242
Colitis 79.82 69.05 4 126275 48524 63314219
Upper respiratory tract infection 79.13 69.05 32 126247 82015 63280728
Vertigo 77.36 69.05 13 126266 59874 63302869
Haemorrhage 77.18 69.05 14 126265 61008 63301735
Agitation 77.13 69.05 13 126266 59744 63302999
Breast cancer stage III 76.82 69.05 99 126180 10287 63352456
Malaise 75.45 69.05 501 125778 415453 62947290
Pulmonary oedema 75.28 69.05 10 126269 54863 63307880
Dysphonia 75.03 69.05 5 126274 47609 63315134
Oedema 74.23 69.05 387 125892 97235 63265508
International normalised ratio increased 72.79 69.05 5 126274 46420 63316323
Blood alkaline phosphatase increased 72.44 69.05 3 126276 42964 63319779
Blood pressure systolic increased 71.78 69.05 6 126273 47391 63315352
Multiple sclerosis relapse 71.09 69.05 7 126272 48471 63314272
Mucosal inflammation 70.90 69.05 6 126273 46922 63315821
Wound infection 70.44 69.05 141 126138 21269 63341474
Burning sensation 69.86 69.05 12 126267 54395 63308348
Rectal haemorrhage 69.55 69.05 8 126271 49022 63313721

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Onychoclasis 149.50 24.23 33 2400 1867 34952631
Tooth loss 126.26 24.23 33 2400 3825 34950673
Lymphoma 91.71 24.23 34 2399 12473 34942025
Neoplasm malignant 79.65 24.23 35 2398 19870 34934628
Alopecia 55.20 24.23 29 2404 24326 34930172
Osteonecrosis of jaw 48.36 24.23 24 2409 17865 34936633
Drug intolerance 46.17 24.23 36 2397 59534 34894964
Administration site discomfort 45.85 24.23 7 2426 46 34954452
Contraindicated product administered 41.46 24.23 23 2410 21458 34933040
Genital herpes simplex 39.63 24.23 7 2426 122 34954376
Suture rupture 37.82 24.23 8 2425 368 34954130
Drug tolerance decreased 33.07 24.23 10 2423 1957 34952541
Drug ineffective 30.98 24.23 85 2348 456666 34497832
Lymphocele 27.62 24.23 8 2425 1349 34953149
Soft tissue disorder 27.35 24.23 7 2426 743 34953755
Elbow operation 26.25 24.23 5 2428 134 34954364
Autoimmune disorder 25.42 24.23 8 2425 1786 34952712
Synovitis 24.26 24.23 14 2419 14052 34940446

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2782.39 52.38 1578 84445 98004 79560361
Systemic lupus erythematosus 2606.89 52.38 1622 84401 119527 79538838
Glossodynia 2451.53 52.38 1473 84550 101864 79556501
Hand deformity 2374.16 52.38 1446 84577 102473 79555892
Pericarditis 2189.44 52.38 1375 84648 102861 79555504
Wound 2118.32 52.38 1402 84621 114777 79543588
Anti-cyclic citrullinated peptide antibody positive 2006.76 52.38 1199 84824 81944 79576421
Alopecia 1754.30 52.38 1664 84359 229691 79428674
Synovitis 1746.76 52.38 1382 84641 149352 79509013
Arthropathy 1689.13 52.38 1450 84573 175661 79482704
Discomfort 1630.01 52.38 1232 84791 124385 79533980
Swelling 1597.46 52.38 1535 84488 215176 79443189
Abdominal discomfort 1557.38 52.38 1618 84405 249109 79409256
Contraindicated product administered 1473.55 52.38 1276 84747 156262 79502103
Rheumatoid factor positive 1461.25 52.38 870 85153 58969 79599396
Duodenal ulcer perforation 1372.50 52.38 867 85156 65344 79593021
Maternal exposure during pregnancy 1366.56 52.38 1150 84873 135388 79522977
Helicobacter infection 1297.42 52.38 853 85170 68851 79589514
Hepatic enzyme increased 1237.21 52.38 1236 84787 181374 79476991
Hypersensitivity 1166.33 52.38 1423 84600 260816 79397549
Drug intolerance 1150.06 52.38 1418 84605 262701 79395664
Infusion related reaction 1068.48 52.38 1277 84746 228960 79429405
Joint swelling 844.88 52.38 1279 84744 287367 79370998
Therapeutic product effect decreased 841.38 52.38 958 85065 162905 79495460
Treatment failure 818.81 52.38 963 85060 169523 79488842
Rheumatic fever 802.47 52.38 455 85568 28070 79630295
Blister 801.26 52.38 805 85218 118671 79539694
Product use issue 782.28 52.38 1044 84979 208778 79449587
Swollen joint count increased 672.73 52.38 376 85647 22551 79635814
Folliculitis 640.27 52.38 508 85515 54872 79603493
Hip arthroplasty 612.72 52.38 416 85607 35340 79623025
Irritable bowel syndrome 610.74 52.38 519 85504 61722 79596643
Muscle injury 608.05 52.38 467 85556 48094 79610271
Blood cholesterol increased 566.27 52.38 567 85456 83153 79575212
Sleep disorder due to general medical condition, insomnia type 545.58 52.38 419 85604 43137 79615228
Type 2 diabetes mellitus 537.36 52.38 465 85558 56657 79601708
Acute kidney injury 533.50 52.38 5 86018 519399 79138966
Impaired healing 528.35 52.38 558 85465 87097 79571268
Knee arthroplasty 506.87 52.38 400 85623 42848 79615517
Death 483.75 52.38 33 85990 566481 79091884
Fibromyalgia 461.43 52.38 450 85573 63890 79594475
Pain 461.25 52.38 1732 84291 702070 78956295
Liver injury 449.74 52.38 419 85604 56195 79602170
Toxicity to various agents 428.36 52.38 5 86018 421535 79236830
Anaemia 414.33 52.38 15 86008 445000 79213365
Musculoskeletal stiffness 411.59 52.38 703 85320 174305 79484060
Psoriatic arthropathy 404.68 52.38 459 85564 77540 79580825
Rash 382.98 52.38 1429 84594 576929 79081436
Fall 364.44 52.38 48 85975 487581 79170784
Ill-defined disorder 359.40 52.38 398 85625 65477 79592888
Drug interaction 348.90 52.38 26 85997 415157 79243208
Hypotension 344.67 52.38 37 85986 440280 79218085
Intentional product use issue 312.36 52.38 576 85447 151536 79506829
Injury 307.23 52.38 398 85625 77098 79581267
General physical health deterioration 293.33 52.38 802 85221 274436 79383929
Stomatitis 291.65 52.38 548 85475 146209 79512156
Neutropenia 273.63 52.38 8 86015 287702 79370663
Adverse event 268.50 52.38 328 85695 59886 79598479
Mobility decreased 263.90 52.38 473 85550 121702 79536663
Prescribed overdose 262.25 52.38 260 85763 37623 79620742
Exposure during pregnancy 249.11 52.38 415 85608 100717 79557648
Foot deformity 248.85 52.38 207 85816 23867 79634498
Constipation 242.64 52.38 16 86007 283034 79375331
Lower respiratory tract infection 242.50 52.38 471 85552 128749 79529616
Completed suicide 240.66 52.38 5 86018 245762 79412603
Infection 240.37 52.38 687 85336 241025 79417340
Sepsis 225.82 52.38 17 86006 269411 79388954
Febrile neutropenia 224.99 52.38 5 86018 230994 79427371
Deep vein thrombosis postoperative 222.90 52.38 141 85882 10611 79647754
Pneumonia 220.23 52.38 233 85790 660013 78998352
Lip dry 218.97 52.38 160 85863 15258 79643107
Facet joint syndrome 218.91 52.38 142 85881 11160 79647205
Thrombocytopenia 216.03 52.38 19 86004 265240 79393125
Dehydration 215.78 52.38 13 86010 248174 79410191
Somnolence 206.31 52.38 13 86010 238968 79419397
Live birth 205.94 52.38 167 85856 18577 79639788
Adjustment disorder with depressed mood 198.02 52.38 123 85900 8963 79649402
Urinary tract infection 193.33 52.38 32 85991 274480 79383885
Autoimmune disorder 193.14 52.38 153 85870 16459 79641906
Gastrointestinal disorder 189.77 52.38 412 85611 121793 79536572
Back pain 184.51 52.38 50 85973 304130 79354235
Adverse drug reaction 181.89 52.38 286 85737 66106 79592259
Erythema 181.78 52.38 16 86007 223274 79435091
Nausea 177.55 52.38 492 85531 956704 78701661
Seizure 176.78 52.38 6 86017 188828 79469537
Grip strength decreased 173.83 52.38 162 85861 21707 79636658
Renal failure 173.25 52.38 11 86012 200957 79457408
Myocardial infarction 171.84 52.38 6 86017 184123 79474242
Peripheral venous disease 171.11 52.38 140 85883 15769 79642596
Haemoglobin decreased 170.22 52.38 20 86003 222099 79436266
Disease progression 168.66 52.38 7 86016 184355 79474010
Dislocation of vertebra 167.51 52.38 105 85918 7775 79650590
Retinitis 166.69 52.38 93 85930 5550 79652815
Respiratory failure 165.07 52.38 7 86016 180904 79477461
Platelet count decreased 163.87 52.38 12 86011 194652 79463713
Anti-cyclic citrullinated peptide antibody 163.53 52.38 93 85930 5759 79652606
Cardiac arrest 162.76 52.38 5 86018 172091 79486274
Condition aggravated 159.42 52.38 1004 85019 500120 79158245
Hyponatraemia 158.63 52.38 8 86015 177840 79480525
Drug ineffective 158.43 52.38 1819 84204 1079094 78579271
Tremor 153.79 52.38 7 86016 170076 79488289
Pancytopenia 152.60 52.38 6 86017 165739 79492626
Pulmonary embolism 146.16 52.38 10 86013 171644 79486721
Renal impairment 144.29 52.38 6 86017 157777 79500588
White blood cell count decreased 144.15 52.38 17 86006 188271 79470094
Osteoarthritis 141.99 52.38 300 85723 87009 79571356
Cerebrovascular accident 141.70 52.38 6 86017 155286 79503079
Cough 140.27 52.38 114 85909 366675 79291690
Blood pressure increased 139.43 52.38 29 85994 211331 79447034
Blood creatinine increased 138.20 52.38 7 86016 155050 79503315
Fatigue 137.97 52.38 1569 84454 928158 78730207
Joint range of motion decreased 136.63 52.38 174 85849 33108 79625257
Cardiac failure 134.87 52.38 8 86015 154834 79503531
Alanine aminotransferase increased 134.07 52.38 11 86012 162559 79495806
Sinusitis 133.60 52.38 489 85534 195012 79463353
Feeling abnormal 133.45 52.38 10 86013 159189 79499176
Syncope 133.00 52.38 18 86005 179431 79478934
Arthralgia 133.00 52.38 1062 84961 570741 79087624
Contusion 131.66 52.38 406 85617 148370 79509995
Gastrointestinal haemorrhage 130.61 52.38 7 86016 147712 79510653
Hypoaesthesia 129.69 52.38 457 85566 178895 79479470
Neuropathy peripheral 127.15 52.38 6 86017 141299 79517066
Chills 126.36 52.38 13 86010 160221 79498144
Systemic lupus erythematosus rash 125.82 52.38 54 85969 1806 79656559
Bradycardia 118.07 52.38 7 86016 135550 79522815
Overdose 117.99 52.38 27 85996 184179 79474186
Myalgia 115.39 52.38 29 85994 185612 79472753
Breast cancer stage III 115.29 52.38 91 85932 9735 79648630
Dyspnoea 115.16 52.38 505 85518 856520 78801845
Hyperhidrosis 112.72 52.38 15 86008 151477 79506888
Multiple organ dysfunction syndrome 111.89 52.38 4 86019 120242 79538123
Obesity 109.90 52.38 161 85862 34964 79623401
Product dose omission issue 107.62 52.38 67 85956 247470 79410895
Aspartate aminotransferase increased 107.39 52.38 12 86011 138629 79519736
Oedema 107.33 52.38 328 85695 119252 79539113
COVID-19 105.29 52.38 21 86002 157653 79500712
Pregnancy 104.92 52.38 137 85886 26714 79631651
Diarrhoea 104.16 52.38 543 85480 879946 78778419
Hyperkalaemia 102.46 52.38 5 86018 114393 79543972
Exostosis 100.86 52.38 107 85916 16751 79641614
Oxygen saturation decreased 100.38 52.38 11 86012 129036 79529329
Tachycardia 99.09 52.38 34 85989 177734 79480631
Bursitis 98.96 52.38 155 85868 35689 79622676
Wound infection 97.79 52.38 125 85898 23866 79634499
Hypoxia 97.60 52.38 3 86020 103240 79555125
Rhabdomyolysis 97.48 52.38 3 86020 103128 79555237
Blood glucose increased 96.99 52.38 7 86016 114968 79543397
Bone erosion 95.82 52.38 107 85916 17740 79640625
Leukopenia 95.73 52.38 8 86015 116505 79541860
Lupus-like syndrome 93.82 52.38 94 85929 13763 79644602
Loss of consciousness 93.82 52.38 32 85991 167911 79490454
Asthenia 93.75 52.38 264 85759 511425 79146940
Dysphagia 93.52 52.38 11 86012 122125 79536240
Joint dislocation 93.44 52.38 103 85920 16836 79641529
Lower limb fracture 93.12 52.38 120 85903 23095 79635270
Coma 91.43 52.38 4 86019 100645 79557720
Cellulitis 90.97 52.38 7 86016 109053 79549312
Sciatica 90.79 52.38 143 85880 33079 79625286
Epistaxis 90.68 52.38 8 86015 111507 79546858
Nasopharyngitis 89.58 52.38 523 85500 253358 79405007
Injection site pain 89.44 52.38 16 86007 129822 79528543
Nerve injury 89.33 52.38 77 85946 9315 79649050
Hypoglycaemia 89.22 52.38 5 86018 101589 79556776
C-reactive protein abnormal 89.04 52.38 175 85848 48192 79610173
Malignant neoplasm progression 88.96 52.38 19 86004 135971 79522394
C-reactive protein 87.78 52.38 59 85964 4920 79653445
Vision blurred 87.76 52.38 7 86016 105891 79552474
Deep vein thrombosis 87.54 52.38 13 86010 120906 79537459
Heart rate increased 87.35 52.38 13 86010 120711 79537654
Chest discomfort 84.94 52.38 22 86001 138022 79520343
Laryngitis 84.13 52.38 95 85928 15944 79642421
Herpes zoster 80.47 52.38 5 86018 93078 79565287
Balance disorder 77.98 52.38 8 86015 98849 79559516
Vomiting 76.70 52.38 414 85609 665414 78992951
Night sweats 76.68 52.38 172 85851 51923 79606442
Palpitations 76.34 52.38 21 86002 126589 79531776
Suicide attempt 76.32 52.38 3 86020 82929 79575436
Lethargy 74.61 52.38 3 86020 81289 79577076
Maternal exposure timing unspecified 73.08 52.38 56 85967 5736 79652629
Hunger 71.84 52.38 54 85969 5374 79652991
Blood pressure decreased 71.30 52.38 11 86012 99455 79558910
X-ray abnormal 70.71 52.38 55 85968 5758 79652607
Inappropriate schedule of product administration 70.35 52.38 28 85995 133600 79524765
Hypokalaemia 69.80 52.38 34 85989 144006 79514359
Stress 69.65 52.38 4 86019 79608 79578757
Influenza 68.48 52.38 27 85996 129579 79528786
Hallucination 67.47 52.38 7 86016 85738 79572627
Seronegative arthritis 67.31 52.38 49 85974 4643 79653722
Walking aid user 67.16 52.38 68 85955 10080 79648285
Agitation 67.15 52.38 13 86010 99702 79558663
Chronic obstructive pulmonary disease 67.14 52.38 7 86016 85412 79572953
Haematochezia 66.83 52.38 8 86015 87637 79570728
International normalised ratio increased 66.45 52.38 7 86016 84714 79573651
Wheezing 65.94 52.38 275 85748 116389 79541976
Bunion operation 65.59 52.38 28 85995 924 79657441
Pulmonary oedema 65.02 52.38 9 86014 88245 79570120
Lupus vulgaris 64.69 52.38 42 85981 3304 79655061
Rash pruritic 64.56 52.38 3 86020 71626 79586739
Pleural effusion 63.54 52.38 39 85984 145223 79513142
Colitis 63.18 52.38 4 86019 73303 79585062
Hypercholesterolaemia 62.54 52.38 99 85924 22996 79635369
Oropharyngeal pain 62.53 52.38 20 86003 109333 79549032
Peripheral swelling 60.93 52.38 498 85525 269119 79389246
Weight increased 60.89 52.38 509 85514 276877 79381488
Suicidal ideation 60.67 52.38 6 86017 76334 79582031
Injection site erythema 59.97 52.38 7 86016 78190 79580175
Gait inability 59.90 52.38 169 85854 58748 79599617
Abdominal pain 59.40 52.38 218 85805 389351 79269014
Haemorrhage 59.04 52.38 13 86010 91105 79567260
Chronic kidney disease 58.88 52.38 3 86020 66151 79592214
Intentional product misuse 58.85 52.38 15 86008 95150 79563215
Dry skin 57.74 52.38 4 86019 67991 79590374
Mucosal inflammation 57.38 52.38 7 86016 75573 79582792
Joint destruction 57.21 52.38 49 85974 5876 79652489
Drug tolerance decreased 56.68 52.38 70 85953 12908 79645457
Foot operation 56.56 52.38 48 85975 5685 79652680
Blood bilirubin increased 55.94 52.38 4 86019 66228 79592137
Swelling face 55.55 52.38 6 86017 71206 79587159
Angioedema 55.43 52.38 8 86015 76027 79582338
Therapy non-responder 54.86 52.38 221 85802 92084 79566281
Gastrooesophageal reflux disease 54.61 52.38 22 86001 104224 79554141
Dysarthria 54.57 52.38 5 86018 67617 79590748
Road traffic accident 54.30 52.38 135 85888 43529 79614836
Sleep disorder 54.04 52.38 209 85814 85468 79572897
Abdominal distension 53.91 52.38 31 85992 119619 79538746
Blood alkaline phosphatase increased 53.33 52.38 4 86019 63660 79594705
Atrial fibrillation 53.11 52.38 82 85941 197804 79460561

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000893 Anti-Inflammatory Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Proctitis indication 3951002 DOID:3127
Keratitis indication 5888003 DOID:4677
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Chronic ulcerative proctitis indication 52231000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Lรถffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Hemorrhoids indication 70153002 DOID:9746
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Infective otitis externa indication 86981007 DOID:9463
Infection by larvae of Trichinella spiralis indication 88264003
Acne vulgaris indication 88616000
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Recurrent herpes simplex labialis indication 402892009
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Itching of ear indication 699392007
Inflammatory dermatosis indication 703938007
Post-Op Ocular Inflammation indication
Staphylococcus Aureus Otitis Externa indication
Mastoidectomy Cavity Infections indication
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Gingival Disorders indication
Synovitis due to Osteoarthritis indication
Minor Bacterial Skin Infections indication
Erythroblastic Anemia indication
Transfusion Reaction Urticaria indication
Superficial Ocular Infection indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Orthostatic hypotension off-label use 28651003
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Chronic purulent otitis media off-label use 38394007 DOID:14247
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Adrenoleukodystrophy off-label use 65389002 DOID:10588
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Pityriasis simplex off-label use 200767005
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Allergic otitis externa off-label use 405821001
Giant cell arteritis off-label use 414341000 DOID:13375
Itching of skin off-label use 418363000
Congenital Pituitary Hypoplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Esophagitis contraindication 16761005 DOID:11963
Disease caused by parasite contraindication 17322007
Mood swings contraindication 18963009
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Cirrhosis of liver contraindication 19943007 DOID:5082
Herpes zoster auricularis contraindication 21954000 DOID:9210
Glaucoma contraindication 23986001 DOID:1686
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Viral disease contraindication 34014006 DOID:934
Severe myopia contraindication 34187009
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Hypercortisolism contraindication 47270006
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Duodenal ulcer disease contraindication 51868009 DOID:1724
Perforation of tympanic membrane contraindication 60442001
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Third degree burn injury contraindication 80247002
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Krukenberg spindle contraindication 85430004
Bacterial infectious disease contraindication 87628006
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of mucous membrane contraindication 95351003
Bilateral cataracts contraindication 95722004
Hypoalbuminemia contraindication 119247004
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Tuberculosis of ear contraindication 186269001
Ophthalmic herpes simplex contraindication 186542001
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Peripheral edema contraindication 271809000
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Severe depression contraindication 310497006
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Skin irritation contraindication 367466007
Vaccinia keratitis contraindication 397552005
Gastric ulcer contraindication 397825006 DOID:10808
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Blister contraindication 417237009
Denuded skin contraindication 418242004
Exposure to varicella contraindication 444453009
Psychiatric Disturbance contraindication
Protozoal Infection contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Kd 6.02 WOMBAT-PK KEGG DRUG
Annexin A1 Cytosolic other WOMBAT-PK
Corticosteroid-binding globulin Secreted Ki 6.89 CHEMBL
Potassium voltage-gated channel subfamily A member 1 Ion channel EC50 4.48 CHEMBL
Sex hormone-binding globulin Secreted Kd 6.43 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.67 CHEMBL
Protein farnesyltransferase Enzyme IC50 4.85 CHEMBL

External reference:

IDSource
4017937 VUID
N0000146287 NUI
D00973 KEGG_DRUG
21655 RXNORM
4017936 VANDF
C0056391 UMLSCUI
CHEBI:3897 CHEBI
CHEMBL1650 ChEMBL_ID
D003348 MESH_DESCRIPTOR_UI
DB01380 DRUGBANK_ID
5745 PUBCHEM_CID
883WKN7W8X UNII
4508 MMSL
51 MMSL
92 MMSL
002146 NDDF
127382005 SNOMEDCT_US
53-06-5 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0143-1202 TABLET 25 mg ORAL ANDA 14 sections
Cortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9700 TABLET 25 mg ORAL ANDA 14 sections
Cortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62135-173 TABLET 25 mg ORAL ANDA 10 sections