cortisone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 734 50-04-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cortisone acetate
  • cortone acetate
  • irisone acetate
  • adrenalex
A naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)
  • Molecular weight: 402.49
  • Formula: C23H30O6
  • CLOGP: 2.02
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 97.74
  • ALOGS: -4.16
  • ROTB: 4
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.28 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 13.87 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.300 Moderate 0.77
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.606 Moderate 0.77
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 40.365 10^-6 cm/s Moderate 0.77
dh-clint Dog hepatocyte intrinsic clearance 80.168 uL/min/10^6 cells Moderate 0.77
dppb Dog plasma protein binding (% unbound) 42.910 % Moderate 0.77
fcs-ppb Fetal calf serum protein binding (% unbound) 57.710 % Moderate 0.77
herg hERG pIC50 4.232 pIC50 Moderate 0.77
hh-clint Human hepatocyte intrinsic clearance 90.782 uL/min/10^6 cells Moderate 0.77
hlm-clint Human liver microsomal intrinsic clearance 101.391 uL/min/mg protein Moderate 0.77
hppb Human plasma protein binding (% unbound) 39.510 % Moderate 0.77
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.377 Moderate 0.77
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 5.559 Moderate 0.77
mh-clint Mouse hepatocyte intrinsic clearance 269.153 Moderate 0.77
mppb Mouse plasma protein binding (% unbound) 44.210 Moderate 0.77
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 10.471 Moderate 0.77
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 57.650 % Moderate 0.77
rat-kpuu-brain Rat brain Kpuu 0.049 % Moderate 0.77
rh-clint Rat hepatocyte intrinsic clearance 194.984 uL/min/10^6 cells Moderate 0.77
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.370 % Moderate 0.77
rppb Rat plasma protein binding (% unbound) 34.830 % Moderate 0.77
solubility-dd Solubility at pH 7.4 in DMSO 948.418 uM Moderate 0.77

Approvals:

DateAgencyCompanyOrphan
June 13, 1950 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 3328.91 68.83 4401 258260 322463 90043323
Systemic lupus erythematosus 3123.96 68.83 4499 258162 357397 90008389
Glossodynia 2875.39 68.83 4068 258593 317711 90048075
Hand deformity 2744.40 68.83 3812 258849 292550 90073236
Wound 2507.93 68.83 3695 258966 299285 90066501
Pericarditis 2288.98 68.83 3332 259329 266819 90098967
Swelling 2006.82 68.83 4008 258653 415050 89950736
Anti-cyclic citrullinated peptide antibody positive 2001.73 68.83 2916 259745 233517 90132269
Abdominal discomfort 1921.54 68.83 4252 258409 473076 89892710
Alopecia 1883.48 68.83 4312 258349 490759 89875027
Arthropathy 1845.92 68.83 3580 259081 362662 90003124
Synovitis 1782 68.83 3321 259340 326431 90039355
Discomfort 1781.48 68.83 2995 259666 271340 90094446
Contraindicated product administered 1721.99 68.83 3218 259443 316921 90048865
Duodenal ulcer perforation 1618.04 68.83 2550 260111 218738 90147048
Helicobacter infection 1593.97 68.83 2567 260094 224283 90141503
Rheumatoid factor positive 1476.13 68.83 2134 260527 169516 90196270
Maternal exposure during pregnancy 1397.72 68.83 3164 259497 356899 90008887
Hepatic enzyme increased 1314.27 68.83 3092 259569 357644 90008142
Infusion related reaction 1267.51 68.83 3334 259327 413446 89952340
Rheumatic fever 1176.13 68.83 1806 260855 151315 90214471
Product use issue 1022.25 68.83 2659 260002 327260 90038526
Type 2 diabetes mellitus 1018.07 68.83 1984 260677 201260 90164526
Hypersensitivity 987.02 68.83 3226 259435 451451 89914335
Treatment failure 966.62 68.83 2474 260187 301454 90064332
Drug intolerance 951.11 68.83 3153 259508 444438 89921348
Swollen joint count increased 903.72 68.83 1347 261314 109859 90255927
Anaemia 902.92 68.83 26 262635 352776 90013010
Acute kidney injury 879.44 68.83 9 262652 320378 90045408
Therapeutic product effect decreased 834.66 68.83 2213 260448 275358 90090428
Toxicity to various agents 810.19 68.83 4 262657 287842 90077944
Blood cholesterol increased 804.39 68.83 1827 260834 206185 90159601
Blister 793.07 68.83 2059 260602 252939 90112847
Joint swelling 784.04 68.83 3207 259454 500093 89865693
Folliculitis 763.79 68.83 1771 260890 202582 90163204
Fall 743.40 68.83 236 262425 481574 89884212
Liver injury 729.29 68.83 1560 261101 169007 90196779
Constipation 719.75 68.83 20 262641 280375 90085411
Drug interaction 716.07 68.83 18 262643 276435 90089351
Urinary tract infection 714.06 68.83 43 262618 305589 90060197
Irritable bowel syndrome 710.61 68.83 1738 260923 205710 90160076
Muscle injury 710.13 68.83 1576 261085 175078 90190708
Cough 695.19 68.83 117 262544 368845 89996941
Fibromyalgia 674.72 68.83 1698 260963 204571 90161215
Death 670.59 68.83 243 262418 456308 89909478
Impaired healing 670.28 68.83 1834 260827 232365 90133421
Psoriatic arthropathy 654.36 68.83 1789 260872 226546 90139240
General physical health deterioration 635.29 68.83 2365 260296 352750 90013036
Neutropenia 600.83 68.83 10 262651 224894 90140892
Back pain 589.88 68.83 104 262557 317071 90048715
Hypotension 566.75 68.83 125 262536 325272 90040514
Product dose omission issue 566.22 68.83 85 262576 291602 90074184
Injury 565.05 68.83 1546 261115 195803 90169983
Erythema 545.36 68.83 29 262632 229217 90136569
Intentional product use issue 531.81 68.83 1607 261054 215285 90150501
Mobility decreased 525.58 68.83 1760 260901 248974 90116812
Sleep disorder due to general medical condition, insomnia type 520.15 68.83 1151 261510 127543 90238243
Facet joint syndrome 518.39 68.83 982 261679 97407 90268379
Somnolence 515.02 68.83 21 262640 209063 90156723
Nausea 504.99 68.83 1600 261061 1108716 89257070
Dehydration 494.73 68.83 15 262646 194432 90171354
Ill-defined disorder 493.41 68.83 1412 261249 183479 90182307
Musculoskeletal stiffness 480.89 68.83 1915 260746 294617 90071169
Lip dry 475.27 68.83 961 261700 99994 90265792
Sepsis 464.38 68.83 12 262649 179802 90185984
Stomatitis 454.22 68.83 1785 260876 272913 90092873
Febrile neutropenia 431.73 68.83 5 262656 158344 90207442
Disease progression 431.36 68.83 4 262657 156611 90209175
Tremor 416.87 68.83 5 262656 153168 90212618
Feeling abnormal 414.53 68.83 16 262645 167219 90198567
Live birth 406.10 68.83 781 261880 78326 90287460
Deep vein thrombosis postoperative 403.36 68.83 731 261930 70078 90295708
Haemoglobin decreased 403.13 68.83 15 262646 161941 90203845
Hip arthroplasty 400.60 68.83 760 261901 75448 90290338
COVID-19 393.40 68.83 24 262637 168819 90196967
Injection site pain 383.66 68.83 32 262629 173667 90192119
Seizure 380.36 68.83 14 262647 152615 90213171
White blood cell count decreased 376.90 68.83 28 262633 167081 90198705
Neuropathy peripheral 366.11 68.83 6 262655 136964 90228822
Platelet count decreased 361.99 68.83 7 262654 136962 90228824
Myalgia 361.30 68.83 42 262619 175083 90190703
Joint range of motion decreased 359.85 68.83 1034 261627 134609 90231177
Breast cancer stage III 358.97 68.83 771 261890 83676 90282110
Autoimmune disorder 347.49 68.83 719 261942 76025 90289761
Renal failure 341.07 68.83 8 262653 130999 90234787
Pain 339.66 68.83 4387 258274 991954 89373832
Lower respiratory tract infection 339.54 68.83 1533 261128 249126 90116660
Pancytopenia 331.51 68.83 3 262658 120260 90245526
Obesity 330.49 68.83 855 261806 104652 90261134
Pulmonary embolism 329.46 68.83 11 262650 130809 90234977
Chills 329.23 68.83 12 262649 131969 90233817
Cerebrovascular accident 327.73 68.83 6 262655 123527 90242259
Rash 326.09 68.83 3631 259030 792469 89573317
Syncope 324.37 68.83 14 262647 132649 90233137
Hyperhidrosis 321.72 68.83 18 262643 136287 90229499
Respiratory failure 321.61 68.83 4 262657 118414 90247372
C-reactive protein abnormal 311.86 68.83 944 261717 126485 90239301
Palpitations 310.93 68.83 22 262639 136706 90229080
Alanine aminotransferase increased 308.94 68.83 7 262654 118331 90247455
Knee arthroplasty 307.10 68.83 718 261943 82464 90283322
Blood pressure increased 304.74 68.83 96 262565 197121 90168665
Diarrhoea 303.51 68.83 1547 261114 937643 89428143
Cardiac failure 300.55 68.83 3 262658 109493 90256293
Influenza 298.52 68.83 29 262632 139235 90226551
Peripheral venous disease 294.26 68.83 710 261951 83211 90282575
Chest discomfort 290.91 68.83 31 262630 138334 90227452
Prescribed overdose 290.33 68.83 776 261885 96849 90268937
Vision blurred 289.99 68.83 6 262655 110287 90255499
Gait inability 287.20 68.83 1006 261655 145450 90220336
Renal impairment 284.36 68.83 4 262657 105417 90260369
Malignant neoplasm progression 280.25 68.83 6 262655 106864 90258922
Myocardial infarction 277.69 68.83 6 262655 105966 90259820
Grip strength decreased 277.45 68.83 738 261923 91838 90273948
Dysphagia 277.34 68.83 11 262650 112267 90253519
Aspartate aminotransferase increased 277.25 68.83 4 262657 102933 90262853
Thrombocytopenia 277.02 68.83 129 262532 208596 90157190
Heart rate increased 275.74 68.83 12 262649 112890 90252896
Blood creatinine increased 268.63 68.83 5 262656 101381 90264405
Oropharyngeal pain 266.41 68.83 17 262644 115170 90250616
Inappropriate schedule of product administration 266.13 68.83 55 262606 149878 90215908
Hypercholesterolaemia 264.52 68.83 766 261895 100126 90265660
Bursitis 263.91 68.83 911 261750 130743 90235043
Lower limb fracture 252.01 68.83 675 261986 84338 90281448
Dyspnoea 250.07 68.83 1514 261147 879441 89486345
Injection site erythema 249.03 68.83 8 262653 98494 90267292
Balance disorder 248.65 68.83 7 262654 97073 90268713
Onychomadesis 248.22 68.83 464 262197 45534 90320252
Oxygen saturation decreased 248.17 68.83 16 262645 107467 90258319
Adverse event 248.11 68.83 827 261834 116591 90249195
Gastrointestinal haemorrhage 245.28 68.83 3 262658 90245 90275541
Hypoaesthesia 240.62 68.83 1647 261014 312563 90053223
Cellulitis 240.00 68.83 5 262656 91332 90274454
Wound infection 239.73 68.83 766 261895 105636 90260150
Sleep disorder 239.37 68.83 1172 261489 196858 90168928
Herpes zoster 238.16 68.83 8 262653 94636 90271150
Dry skin 234.75 68.83 4 262657 88069 90277717
Flushing 231.90 68.83 5 262656 88486 90277300
Blepharospasm 231.89 68.83 503 262158 54942 90310844
Prescribed underdose 230.84 68.83 604 262057 74415 90291371
Night sweats 227.44 68.83 855 261806 127911 90237875
Road traffic accident 227.35 68.83 758 261903 106868 90258918
Lupus vulgaris 225.24 68.83 440 262221 44619 90321167
Sciatica 224.89 68.83 726 261935 100656 90265130
Blood glucose increased 223.45 68.83 13 262648 95233 90270553
Deep vein thrombosis 216.50 68.83 12 262649 91608 90274178
Osteoarthritis 215.22 68.83 1128 261533 194602 90171184
Bradycardia 214.91 68.83 6 262655 83841 90281945
Pulmonary fibrosis 211.18 68.83 739 261922 106764 90259022
Anti-cyclic citrullinated peptide antibody 209.89 68.83 322 262339 26899 90338887
Dry mouth 209.48 68.83 1071 261590 182988 90182798
Epistaxis 204.76 68.83 10 262651 85115 90280671
Drug abuse 203.60 68.83 8 262653 82339 90283447
Suicide attempt 202.75 68.83 3 262658 75396 90290390
Wheezing 200.98 68.83 1279 261382 236801 90128985
Foot deformity 200.91 68.83 497 262164 59154 90306632
C-reactive protein 200.84 68.83 341 262320 31026 90334760
Rhinorrhoea 198.52 68.83 15 262646 88301 90277485
Coma 194.83 68.83 3 262658 72629 90293157
Swelling face 194.27 68.83 10 262651 81342 90284444
Chronic obstructive pulmonary disease 194.14 68.83 4 262657 73825 90291961
Nasal congestion 193.82 68.83 12 262649 83402 90282384
Interstitial lung disease 190.35 68.83 7 262654 76398 90289388
Adjustment disorder with depressed mood 184.98 68.83 467 262194 56286 90309500
Pneumonia 179.95 68.83 1098 261563 636961 89728825
Suicidal ideation 179.84 68.83 8 262653 73847 90291939
Lung disorder 179.58 68.83 885 261776 148998 90216788
Blood pressure decreased 179.50 68.83 9 262652 74886 90290900
Colitis 179.27 68.83 5 262656 69937 90295849
Cognitive disorder 177.76 68.83 5 262656 69402 90296384
Infection 173.21 68.83 1706 260955 360388 90005398
Angioedema 172.68 68.83 3 262658 64873 90300913
Gastrointestinal disorder 172.39 68.83 1304 261357 255383 90110403
Cataract 171.71 68.83 9 262652 72083 90293703
Haematochezia 168.44 68.83 9 262652 70904 90294882
Illness 168.16 68.83 20 262641 81949 90283837
Retinitis 166.67 68.83 354 262307 38104 90327682
Dislocation of vertebra 165.44 68.83 444 262217 55524 90310262
Onychomycosis 165.41 68.83 347 262314 37029 90328757
Oedema 164.68 68.83 1069 261592 199226 90166560
Lethargy 163.76 68.83 4 262657 63135 90302651
Thrombosis 163.06 68.83 13 262648 73238 90292548
Hypoglycaemia 162.43 68.83 10 262651 69838 90295948
Productive cough 160.10 68.83 18 262643 77045 90288741
Confusional state 159.88 68.83 1767 260894 384438 89981348
Nail disorder 159.17 68.83 453 262208 58614 90307172
Epilepsy 157.89 68.83 561 262100 81645 90284141
Hot flush 157.31 68.83 3 262658 59485 90306301
Skin exfoliation 157.10 68.83 10 262651 67903 90297883
Weight decreased 156.98 68.83 569 262092 379341 89986445
Multiple organ dysfunction syndrome 155.32 68.83 11 262650 68325 90297461
Overdose 154.00 68.83 138 262523 157571 90208215
Cystitis 150.89 68.83 11 262650 66707 90299079
Cardiac disorder 149.86 68.83 3 262658 56869 90308917
Hallucination 148.82 68.83 11 262650 65948 90299838
Dysphonia 146.79 68.83 9 262652 63075 90302711
Vertigo 145.80 68.83 16 262645 69795 90295991
Mucosal inflammation 141.10 68.83 6 262655 57619 90308167
Back injury 140.98 68.83 373 262288 46249 90319537
Unevaluable event 140.28 68.83 4 262657 54844 90310942
Abdominal pain 138.77 68.83 632 262029 395089 89970697
Dry eye 138.70 68.83 7 262654 57924 90307862
Dysarthria 135.68 68.83 5 262656 54477 90311309
Metabolic acidosis 135.66 68.83 6 262655 55670 90310116
Pulmonary oedema 135.48 68.83 12 262649 62068 90303718
Drug ineffective for unapproved indication 134.89 68.83 17 262644 66627 90299159
Hypertension 134.26 68.83 1964 260697 455568 89910218
Blood pressure systolic increased 133.75 68.83 9 262652 58336 90307450
Liver function test abnormal 132.72 68.83 3 262658 50842 90314944
Exostosis 132.13 68.83 396 262265 52738 90313048
Inflammation 131.72 68.83 928 261733 177664 90188122
Dyspnoea exertional 129.32 68.83 26 262635 72262 90293524
Burning sensation 128.88 68.83 16 262645 63436 90302350
Hypothyroidism 128.55 68.83 6 262655 53121 90312665
Abortion spontaneous 127.95 68.83 7 262654 54049 90311737
Agitation 126.78 68.83 21 262640 67077 90298709
Leukopenia 126.38 68.83 67 262594 100643 90265143
Multiple sclerosis relapse 126.26 68.83 6 262655 52299 90313487
Rash erythematous 126.12 68.83 19 262642 65085 90300701
Contusion 125.61 68.83 1195 261466 250021 90115765
Blood alkaline phosphatase increased 124.86 68.83 3 262658 48076 90317710
Atrial fibrillation 124.46 68.83 122 262539 133489 90232297
Hyperglycaemia 122.54 68.83 6 262655 50964 90314822
Disturbance in attention 122.11 68.83 3 262658 47106 90318680
Bone erosion 121.46 68.83 384 262277 52637 90313149
Intentional product misuse 120.97 68.83 54 262607 89550 90276236
Depressed mood 120.46 68.83 6 262655 50216 90315570
Seronegative arthritis 119.07 68.83 200 262461 18034 90347752
Swollen tongue 118.84 68.83 3 262658 45953 90319833
Urticaria 118.60 68.83 1407 261254 311327 90054459
Lymphadenopathy 118.33 68.83 3 262658 45772 90320014
X-ray abnormal 118.15 68.83 344 262317 45080 90320706
Bone pain 118.01 68.83 19 262642 61964 90303822
Lupus-like syndrome 117.66 68.83 360 262301 48486 90317300
Condition aggravated 117.39 68.83 2398 260263 593147 89772639
Loss of consciousness 117.36 68.83 140 262521 140098 90225688
Drug tolerance decreased 117.06 68.83 276 262385 31854 90333932
Vomiting 117.05 68.83 1596 261065 786697 89579089
Hepatic cirrhosis 116.64 68.83 426 262235 62827 90302959
Liver disorder 116.52 68.83 674 261987 120595 90245191
Anaphylactic reaction 116.20 68.83 54 262607 87470 90278316
Exposure during pregnancy 116.18 68.83 1128 261533 237282 90128504
Skin ulcer 113.98 68.83 8 262653 50067 90315719
Blood potassium decreased 113.53 68.83 6 262655 47721 90318065
Diverticulitis 113.04 68.83 4 262657 45183 90320603
Heart rate decreased 112.40 68.83 12 262649 53493 90312293
Blood bilirubin increased 111.80 68.83 3 262658 43467 90322319
Laryngitis 111.19 68.83 362 262299 50391 90315395
Skin discolouration 110.59 68.83 4 262657 44311 90321475
Breast cancer 110.56 68.83 13 262648 53748 90312038
Red blood cell count decreased 109.72 68.83 6 262655 46345 90319441
Blood pressure fluctuation 109.48 68.83 12 262649 52401 90313385
Adverse drug reaction 109.13 68.83 644 262017 116057 90249729
Surgery 108.83 68.83 5 262656 44882 90320904
Arrhythmia 108.58 68.83 3 262658 42329 90323457
Haemorrhage 108.47 68.83 33 262628 69336 90296450
Eczema 108.20 68.83 13 262648 52857 90312929
Transient ischaemic attack 107.39 68.83 4 262657 43172 90322614
Viral infection 105.99 68.83 3 262658 41411 90324375
Therapy non-responder 105.29 68.83 718 261943 135986 90229800
International normalised ratio increased 103.65 68.83 9 262652 47307 90318479
Haematocrit decreased 103.62 68.83 4 262657 41828 90323958
Femur fracture 103.07 68.83 8 262653 46074 90319712
Flatulence 102.32 68.83 4 262657 41363 90324423
Pleural effusion 102.30 68.83 104 262557 111887 90253899
Joint destruction 102.18 68.83 157 262504 13130 90352656
Respiratory tract infection 102.09 68.83 23 262638 59055 90306731
Fluid retention 101.45 68.83 65 262596 88026 90277760
Staphylococcal infection 101.41 68.83 11 262650 48428 90317358
Infusion site reaction 101.38 68.83 191 262470 18848 90346938
Rash maculo-papular 101.10 68.83 4 262657 40929 90324857
Eye pain 100.69 68.83 7 262654 44161 90321625
Pain in jaw 100.19 68.83 11 262650 47974 90317812
Taste disorder 99.09 68.83 397 262264 61149 90304637
Nasopharyngitis 98.35 68.83 1692 260969 405412 89960374
Hepatic failure 97.72 68.83 4 262657 39724 90326062
Hypokalaemia 97.35 68.83 143 262518 130973 90234813
Cholelithiasis 95.78 68.83 18 262643 52488 90313298
Pneumonitis 95.15 68.83 9 262652 44161 90321625
Ulcer haemorrhage 94.69 68.83 225 262436 26096 90339690
Transaminases increased 94.07 68.83 3 262658 37189 90328597
Urinary incontinence 91.68 68.83 4 262657 37562 90328224
Headache 91.47 68.83 1858 260803 860888 89504898
Diabetes mellitus 89.30 68.83 38 262623 64837 90300949
Renal disorder 89.30 68.83 5 262656 37854 90327932
Gastritis 88.65 68.83 9 262652 41744 90324042
Lymphocyte count decreased 88.03 68.83 3 262658 35047 90330739
Dysgeusia 87.79 68.83 22 262639 52538 90313248
Musculoskeletal pain 87.72 68.83 819 261842 170432 90195354
Drug tolerance 87.16 68.83 173 262488 17743 90348043
Respiratory distress 86.43 68.83 7 262654 38939 90326847
Irritability 86.37 68.83 4 262657 35658 90330128
Asthenia 86.32 68.83 1061 261600 532690 89833096
Neoplasm progression 86.13 68.83 13 262648 44473 90321313
Joint dislocation 85.37 68.83 304 262357 44278 90321508
Hepatotoxicity 85.17 68.83 15 262646 45827 90319959
Generalised tonic-clonic seizure 84.25 68.83 4 262657 34899 90330887
Haematoma 84.00 68.83 8 262653 39040 90326746
Localised infection 83.85 68.83 3 262658 33559 90332227
C-reactive protein increased 83.85 68.83 849 261812 180540 90185246
Fungal infection 83.68 68.83 12 262649 42649 90323137
Basal cell carcinoma 83.36 68.83 3 262658 33386 90332400
No adverse event 82.71 68.83 47 262614 67935 90297851
Coeliac disease 82.71 68.83 301 262360 44309 90321477
Drug eruption 82.53 68.83 5 262656 35402 90330384
Hip fracture 82.49 68.83 3 262658 33074 90332712
Throat irritation 82.08 68.83 20 262641 48675 90317111
Nervousness 81.90 68.83 4 262657 34052 90331734
Eye irritation 81.68 68.83 4 262657 33974 90331812
Oral pain 81.38 68.83 3 262658 32680 90333106
Hypophagia 81.05 68.83 6 262655 35931 90329855
Tachycardia 79.22 68.83 216 262445 157457 90208329
Weight increased 78.98 68.83 1673 260988 416254 89949532
Neoplasm malignant 78.32 68.83 5 262656 33875 90331911
Pregnancy 78.31 68.83 372 262289 61675 90304111
Neuralgia 78.06 68.83 3 262658 31497 90334289
Restlessness 77.69 68.83 7 262654 35713 90330073
Oral herpes 77.34 68.83 5 262656 33519 90332267
Bronchitis 77.21 68.83 209 262452 152718 90213068
Skin lesion 76.92 68.83 9 262652 37356 90328430
Angina pectoris 76.84 68.83 11 262650 39149 90326637
Mouth ulceration 76.67 68.83 12 262649 39962 90325824
Gamma-glutamyltransferase increased 76.03 68.83 10 262651 37942 90327844
Liver function test increased 75.95 68.83 463 262198 84392 90281394
Sleep apnoea syndrome 75.48 68.83 4 262657 31743 90334043
Ocular hyperaemia 75.21 68.83 6 262655 33792 90331994
Limb injury 74.82 68.83 4 262657 31504 90334282
Systemic lupus erythematosus rash 74.34 68.83 59 262602 2330 90363456
Psychotic disorder 74.05 68.83 4 262657 31226 90334560
Haemoptysis 73.91 68.83 6 262655 33314 90332472
Pollakiuria 73.06 68.83 6 262655 32999 90332787
Disease recurrence 72.90 68.83 11 262650 37642 90328144
Eye pruritus 71.14 68.83 3 262658 29024 90336762
Spondylitis 70.29 68.83 138 262523 14040 90351746

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Onychoclasis 139.26 25.82 33 2867 2619 42615816
Tooth loss 124.55 25.82 33 2867 4121 42614314
Lymphoma 87.94 25.82 34 2866 14287 42604148
Suture rupture 83.25 25.82 16 2884 462 42617973
Neoplasm malignant 75.90 25.82 35 2865 22708 42595727
Soft tissue disorder 68.40 25.82 15 2885 839 42617596
Lymphocele 64.53 25.82 16 2884 1531 42616904
Acetabulum fracture 59.66 25.82 12 2888 440 42617995
Autoimmune disorder 57.00 25.82 16 2884 2471 42615964
Alopecia 50.79 25.82 29 2871 29247 42589188
Osteonecrosis of jaw 47.43 25.82 24 2876 19025 42599410
Lymphoedema 46.16 25.82 16 2884 4932 42613503
Administration site discomfort 46.01 25.82 7 2893 46 42618389
Erysipelas 42.40 25.82 16 2884 6280 42612155
Genital herpes simplex 39.68 25.82 7 2893 124 42618311
Drug intolerance 39.36 25.82 37 2863 80387 42538048
Hepatitis 39.35 25.82 24 2876 27276 42591159
Contraindicated product administered 38.45 25.82 23 2877 25249 42593186
Eye inflammation 36.29 25.82 12 2888 3206 42615229
Wound dehiscence 34.33 25.82 12 2888 3788 42614647
Sleep disorder 33.35 25.82 27 2873 48068 42570367
Drug-induced liver injury 31.99 25.82 24 2876 38249 42580186
Drug tolerance decreased 31.49 25.82 10 2890 2350 42616085
Venous thrombosis limb 31.46 25.82 10 2890 2359 42616076
Impaired healing 29.84 25.82 17 2883 17036 42601399
Prostate cancer 28.72 25.82 24 2876 44619 42573816

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 2878.41 62.46 2690 200904 211880 110173825
Systemic lupus erythematosus 2779.65 62.46 2850 200744 251488 110134217
Glossodynia 2522.14 62.46 2541 201053 219463 110166242
Hand deformity 2508.06 62.46 2515 201079 215991 110169714
Pericarditis 2356.23 62.46 2435 201159 216679 110169026
Wound 2141.69 62.46 2390 201204 232047 110153658
Anti-cyclic citrullinated peptide antibody positive 2082.46 62.46 2092 201502 179892 110205813
Synovitis 1938.31 62.46 2452 201142 271640 110114065
Duodenal ulcer perforation 1893.51 62.46 1966 201628 175734 110209971
Helicobacter infection 1873.26 62.46 1976 201618 179901 110205804
Arthropathy 1694.85 62.46 2353 201241 285169 110100536
Swelling 1663.85 62.46 2592 201002 348449 110037256
Alopecia 1663.55 62.46 2646 200948 362107 110023598
Rheumatoid factor positive 1528.29 62.46 1526 202068 130114 110255591
Contraindicated product administered 1502.02 62.46 2058 201536 246209 110139496
Abdominal discomfort 1428.26 62.46 2580 201014 391278 109994427
Hepatic enzyme increased 1407.88 62.46 2288 201306 318604 110067101
Discomfort 1364.05 62.46 1823 201771 212884 110172821
Rheumatic fever 1353.28 62.46 1383 202211 121196 110264509
Maternal exposure during pregnancy 1321.03 62.46 1963 201631 252920 110132785
Infusion related reaction 1175.70 62.46 2331 201263 378831 110006874
Type 2 diabetes mellitus 1173.42 62.46 1536 202058 175696 110210009
Blister 1112.20 62.46 1705 201889 225671 110160034
Hypersensitivity 1108.34 62.46 2354 201240 401644 109984061
Acute kidney injury 1106.17 62.46 12 203582 635418 109750287
Irritable bowel syndrome 1097.60 62.46 1430 202164 162785 110222920
Folliculitis 1094.33 62.46 1443 202151 166210 110219495
Fibromyalgia 1069.48 62.46 1441 202153 169468 110216237
Impaired healing 1050.32 62.46 1537 202057 195180 110190525
Muscle injury 1046.74 62.46 1293 202301 139514 110246191
Drug intolerance 1001.82 62.46 2269 201325 404243 109981462
Therapeutic product effect decreased 996.67 62.46 1687 201907 242629 110143076
Psoriatic arthropathy 972.66 62.46 1483 202111 195278 110190427
Joint swelling 966.39 62.46 2357 201237 440488 109945217
Swollen joint count increased 957.79 62.46 963 202631 82698 110303007
Anaemia 907.30 62.46 21 203573 547065 109838640
Liver injury 902.69 62.46 1243 202351 149170 110236535
Treatment failure 869.04 62.46 1708 201886 275526 110110179
Facet joint syndrome 863.24 62.46 976 202618 95852 110289853
Toxicity to various agents 850.64 62.46 6 203588 480549 109905156
Blood cholesterol increased 849.34 62.46 1347 202247 183438 110202267
Ill-defined disorder 798.74 62.46 1199 202395 155654 110230051
Drug interaction 796.99 62.46 28 203566 500155 109885550
Lip dry 779.09 62.46 941 202653 99142 110286563
Sleep disorder due to general medical condition, insomnia type 778.25 62.46 966 202628 104677 110281028
Injury 763.88 62.46 1255 202339 176010 110209695
Mobility decreased 723.61 62.46 1446 202148 235976 110149729
Stomatitis 696.86 62.46 1537 202057 268705 110117000
Death 680.87 62.46 220 203374 698649 109687056
Product use issue 659.89 62.46 1641 201953 310054 110075651
Joint range of motion decreased 646.93 62.46 950 202644 120882 110264823
Neutropenia 634.29 62.46 11 203583 374609 110011096
Hypotension 623.96 62.46 107 203487 523742 109861963
Breast cancer stage III 581.85 62.46 723 202871 78394 110307311
Constipation 566.32 62.46 21 203573 357765 110027940
C-reactive protein abnormal 564.94 62.46 923 202671 128772 110256933
Lower respiratory tract infection 557.12 62.46 1320 202274 241786 110143919
Febrile neutropenia 555.19 62.46 5 203589 316762 110068943
Obesity 535.27 62.46 837 202757 112514 110273191
Bursitis 532.92 62.46 900 202694 129018 110256687
Musculoskeletal stiffness 532.92 62.46 1416 202178 278406 110107299
Live birth 531.96 62.46 648 202946 68836 110316869
Deep vein thrombosis postoperative 510.20 62.46 587 203007 58704 110327001
Peripheral venous disease 505.55 62.46 696 202898 83421 110302284
General physical health deterioration 494.87 62.46 1813 201781 423482 109962223
Fall 486.96 62.46 252 203342 603230 109782475
Sepsis 486.46 62.46 29 203565 327317 110058388
Cough 478.96 62.46 129 203465 461512 109924193
Osteoarthritis 470.71 62.46 1039 202555 181584 110204121
Intentional product use issue 462.33 62.46 1245 202349 246661 110139044
Hypoaesthesia 460.01 62.46 1447 202147 312776 110072929
Autoimmune disorder 458.52 62.46 584 203010 64899 110320806
Hip arthroplasty 454.25 62.46 537 203057 55276 110330429
Gait inability 449.59 62.46 859 202735 135517 110250188
Night sweats 445.48 62.46 847 202747 133136 110252569
Urinary tract infection 445.06 62.46 43 203551 326239 110059466
Erythema 444.93 62.46 22 203572 291425 110094280
Sleep disorder 441.37 62.46 1066 202528 197578 110188127
Dehydration 440.21 62.46 17 203577 279494 110106211
Grip strength decreased 436.81 62.46 633 202961 79541 110306164
Somnolence 434.05 62.46 29 203565 297420 110088285
Completed suicide 419.24 62.46 5 203589 242376 110143329
Dry mouth 410.42 62.46 1041 202553 198907 110186798
Disease progression 409.52 62.46 8 203586 244026 110141679
Hypercholesterolaemia 404.33 62.46 653 202941 90184 110295521
Blepharospasm 398.01 62.46 498 203096 54353 110331352
Onychomadesis 397.76 62.46 455 203139 45208 110340497
Wound infection 396.48 62.46 669 202925 95796 110289909
Back pain 385.98 62.46 103 203491 370893 110014812
Knee arthroplasty 370.23 62.46 524 203070 64424 110321281
Renal failure 366.54 62.46 11 203583 226563 110159142
Sciatica 364.17 62.46 629 202965 91770 110293935
Haemoglobin decreased 363.60 62.46 24 203570 248703 110137002
Lower limb fracture 362.04 62.46 561 203033 74787 110310918
Respiratory failure 361.54 62.46 7 203587 215325 110170380
Hyponatraemia 354.17 62.46 10 203584 217643 110168062
Pancytopenia 347.24 62.46 8 203586 209605 110176100
Product dose omission issue 344.95 62.46 84 203510 321698 110064007
Seizure 343.06 62.46 15 203579 221170 110164535
Tremor 341.87 62.46 6 203588 202226 110183479
Adverse event 338.59 62.46 669 202925 108140 110277565
COVID-19 337.58 62.46 31 203563 245029 110140676
Platelet count decreased 337.54 62.46 22 203572 230421 110155284
Exposure during pregnancy 336.58 62.46 865 202729 166559 110219146
Cardiac arrest 336.12 62.46 5 203589 196748 110188957
Pulmonary embolism 334.45 62.46 14 203580 214460 110171245
Gastrointestinal disorder 330.09 62.46 1088 202506 240864 110144841
Prescribed overdose 328.01 62.46 583 203011 86998 110298707
Wheezing 325.51 62.46 1122 202472 254108 110131597
Road traffic accident 324.19 62.46 652 202942 106746 110278959
Myocardial infarction 323.46 62.46 6 203588 192077 110193628
Thrombocytopenia 323.34 62.46 119 203475 348766 110036939
Renal impairment 316.87 62.46 6 203588 188439 110197266
Nail disorder 309.11 62.46 453 203141 57482 110328223
Inflammation 308.77 62.46 918 202676 192320 110193385
White blood cell count decreased 308.12 62.46 32 203562 229358 110156347
Cardiac failure 307.58 62.46 8 203586 187618 110198087
Lung disorder 305.58 62.46 874 202720 179173 110206532
Syncope 300.62 62.46 18 203576 202518 110183187
C-reactive protein 299.94 62.46 323 203271 30008 110355697
Chills 298.63 62.46 12 203582 190568 110195137
Neuropathy peripheral 296.33 62.46 7 203587 179270 110206435
Blood creatinine increased 295.36 62.46 9 203585 182880 110202825
Drug abuse 289.19 62.46 8 203586 177403 110208302
Cerebrovascular accident 288.92 62.46 10 203584 181274 110204431
Alanine aminotransferase increased 286.52 62.46 12 203582 183761 110201944
Adjustment disorder with depressed mood 283.20 62.46 376 203218 43507 110342198
Nausea 280.22 62.46 1248 202346 1234442 109151263
Onychomycosis 273.42 62.46 346 203248 38185 110347520
Feeling abnormal 271.45 62.46 15 203579 180696 110205009
Hyperhidrosis 271.00 62.46 19 203575 187279 110198426
Gastrointestinal haemorrhage 267.81 62.46 8 203586 165510 110220195
Myalgia 267.59 62.46 44 203550 222337 110163368
Foot deformity 267.25 62.46 385 203209 48095 110337610
Dislocation of vertebra 265.97 62.46 364 203230 43357 110342348
Infection 262.44 62.46 1339 202255 360861 110024844
Blood pressure increased 257.03 62.46 78 203516 258295 110127410
Back injury 253.41 62.46 371 203223 47028 110338677
Epilepsy 251.10 62.46 564 203030 99645 110286060
Sinusitis 247.36 62.46 1142 202452 295546 110090159
Multiple organ dysfunction syndrome 246.68 62.46 7 203587 151703 110234002
Bradycardia 246.36 62.46 9 203585 155508 110230197
Malignant neoplasm progression 246.06 62.46 20 203574 174547 110211158
Aspartate aminotransferase increased 244.24 62.46 12 203582 159924 110225781
Urticaria 242.40 62.46 1195 202399 317662 110068043
Musculoskeletal pain 240.60 62.46 813 202781 182210 110203495
Anti-cyclic citrullinated peptide antibody 239.72 62.46 236 203358 19728 110365977
Nasopharyngitis 238.59 62.46 1388 202206 392973 109992732
Rash 235.48 62.46 2426 201168 818538 109567167
Pain 234.53 62.46 2736 200858 952219 109433486
Lupus vulgaris 232.12 62.46 299 203295 33584 110352121
Interstitial lung disease 231.98 62.46 5 203589 139329 110246376
Pneumonia 231.54 62.46 833 202761 875881 109509824
Dysphagia 229.92 62.46 13 203581 153587 110232118
Hyperkalaemia 225.59 62.46 5 203589 135791 110249914
Retinitis 222.60 62.46 286 203308 32041 110353664
Hypoxia 222.45 62.46 3 203591 129512 110256193
Oxygen saturation decreased 221.21 62.46 18 203576 156964 110228741
Injection site pain 219.03 62.46 33 203561 177889 110207816
Oedema 217.21 62.46 863 202731 209113 110176592
Chest discomfort 214.57 62.46 32 203562 173816 110211889
Contusion 212.30 62.46 922 202672 232439 110153266
Vision blurred 205.99 62.46 7 203587 129015 110256690
Rhabdomyolysis 205.87 62.46 3 203591 120398 110265307
Influenza 204.44 62.46 33 203561 169068 110216637
Heart rate increased 204.05 62.46 16 203578 143818 110241887
Dyspnoea 202.99 62.46 1202 202392 1105670 109280035
Atrial fibrillation 201.70 62.46 85 203509 229557 110156148
Blood glucose increased 198.97 62.46 11 203583 132485 110253220
Pregnancy 197.70 62.46 345 203249 50722 110334983
Cellulitis 197.18 62.46 8 203586 126008 110259697
Coma 197.13 62.46 4 203590 117865 110267840
Weight increased 195.80 62.46 1383 202211 418261 109967444
Palpitations 192.63 62.46 31 203563 159181 110226524
Epistaxis 192.19 62.46 12 203582 130360 110255345
X-ray abnormal 191.78 62.46 290 203304 37827 110347878
Taste disorder 190.19 62.46 391 203203 64996 110320709
Deep vein thrombosis 189.14 62.46 19 203575 139868 110245837
Inappropriate schedule of product administration 185.98 62.46 71 203523 203566 110182139
Dry skin 178.67 62.46 4 203590 107649 110278056
Flushing 177.42 62.46 3 203591 104733 110280972
Exostosis 177.29 62.46 310 203284 45646 110340059
Herpes zoster 176.19 62.46 5 203589 108374 110277331
Suicide attempt 174.98 62.46 3 203591 103391 110282314
Chronic obstructive pulmonary disease 173.98 62.46 6 203588 109152 110276553
Hypoglycaemia 173.23 62.46 10 203584 116094 110269611
Coeliac disease 171.41 62.46 295 203299 42892 110342813
Prescribed underdose 171.34 62.46 374 203220 64800 110320905
Confusional state 171.10 62.46 1459 202135 467221 109918484
Balance disorder 171.01 62.46 11 203583 116549 110269156
Stress 170.74 62.46 5 203589 105343 110280362
Oropharyngeal pain 169.02 62.46 24 203570 135252 110250453
Colitis 165.31 62.46 5 203589 102318 110283387
Peripheral swelling 164.27 62.46 1289 202305 402745 109982960
Diarrhoea 162.71 62.46 1331 202263 1138174 109247531
Bone erosion 162.52 62.46 300 203294 46071 110339634
Lupus-like syndrome 161.05 62.46 278 203316 40514 110345191
Haematochezia 160.69 62.46 14 203580 115510 110270195
Adverse drug reaction 160.50 62.46 493 203101 105066 110280639
Lethargy 157.19 62.46 3 203591 93573 110292132
Liver disorder 157.12 62.46 597 202997 141646 110244059
Hypertension 153.85 62.46 1524 202070 508560 109877145
Metabolic acidosis 153.84 62.46 7 203587 99737 110285968
Blood pressure decreased 152.09 62.46 17 203577 115074 110270631
C-reactive protein increased 151.66 62.46 797 202797 217122 110168583
Infusion site reaction 150.26 62.46 174 203420 17508 110368197
Mucosal inflammation 147.45 62.46 7 203587 96134 110289571
Laryngitis 144.40 62.46 271 203323 42140 110343565
Suicidal ideation 143.56 62.46 7 203587 93930 110291775
Pulmonary oedema 143.32 62.46 11 203583 100648 110285057
Hallucination 141.87 62.46 12 203582 101420 110284285
Overdose 141.44 62.46 133 203461 233661 110152044
Injection site erythema 140.84 62.46 8 203586 94168 110291537
Haemorrhage 140.38 62.46 16 203578 106676 110279029
Seronegative arthritis 140.34 62.46 146 203448 13031 110372674
Product quality issue 139.63 62.46 384 203210 76915 110308790
Cognitive disorder 138.80 62.46 5 203589 87506 110298199
Drug hypersensitivity 138.48 62.46 1360 202234 452730 109932975
Agitation 136.78 62.46 22 203572 113029 110272676
Finger deformity 136.54 62.46 230 203364 32862 110352843
Pulmonary fibrosis 135.53 62.46 455 203139 101587 110284118
Swelling face 134.58 62.46 9 203585 92312 110293393
Loss of consciousness 133.09 62.46 100 203494 196206 110189499
Dysarthria 132.76 62.46 5 203589 84116 110301589
Joint dislocation 132.35 62.46 231 203363 33959 110351746
Pleural effusion 131.84 62.46 82 203512 177627 110208078
Drug ineffective for unapproved indication 131.42 62.46 17 203577 102821 110282884
Abdominal pain upper 130.58 62.46 1093 202501 348018 110037687
Thrombosis 129.56 62.46 22 203572 108640 110277065
Rhinorrhoea 128.75 62.46 18 203576 102648 110283057
Angioedema 126.56 62.46 16 203578 98484 110287221
Nasal congestion 126.19 62.46 16 203578 98266 110287439
Productive cough 126.04 62.46 28 203566 114277 110271428
Chronic kidney disease 125.96 62.46 3 203591 76288 110309417
Migraine 123.70 62.46 634 202960 171018 110214687
Rash maculo-papular 122.23 62.46 3 203591 74219 110311486
Influenza like illness 122.18 62.46 11 203583 88401 110297304
Intentional product misuse 121.89 62.46 46 203548 132858 110252847
Memory impairment 121.38 62.46 697 202897 196247 110189458
Liver function test increased 119.52 62.46 397 203197 88151 110297554
International normalised ratio increased 119.37 62.46 11 203583 86761 110298944
Product label confusion 119.03 62.46 176 203418 22501 110363204
Blood bilirubin increased 118.25 62.46 5 203589 75967 110309738
Injection site reaction 118.14 62.46 397 203197 88673 110297032
Dyspnoea exertional 117.79 62.46 24 203570 104036 110281669
Cataract 115.13 62.46 8 203586 79477 110306228
Leukopenia 114.10 62.46 66 203528 148725 110236980
Hypokalaemia 113.65 62.46 101 203493 182347 110203358
Blood alkaline phosphatase increased 112.69 62.46 4 203590 70931 110314774
Skin exfoliation 110.78 62.46 15 203579 87636 110298069
Hepatic cirrhosis 110.49 62.46 324 203270 67302 110318403
Hypothyroidism 109.60 62.46 6 203588 72893 110312812
Hepatic failure 108.77 62.46 4 203590 68735 110316970
Therapy non-responder 107.80 62.46 573 203021 156734 110228971
Weight decreased 107.78 62.46 469 203125 467588 109918117
Hot flush 107.50 62.46 3 203591 66033 110319672
Heart rate decreased 107.41 62.46 13 203581 82743 110302962
Joint destruction 107.24 62.46 116 203478 10827 110374878
Pneumonitis 107.18 62.46 9 203585 76522 110309183
Urinary retention 107.10 62.46 5 203589 69678 110316027
Arrhythmia 106.91 62.46 5 203589 69570 110316135
Dysphonia 106.14 62.46 9 203585 75920 110309785
Hyperglycaemia 104.20 62.46 16 203578 85074 110300631
Lymphadenopathy 103.55 62.46 3 203591 63832 110321873
Maternal exposure timing unspecified 103.05 62.46 158 203436 20855 110364850
Blood pressure systolic increased 103.02 62.46 15 203579 82976 110302729
Cerebral haemorrhage 102.05 62.46 4 203590 64964 110320741
Tachycardia 101.20 62.46 163 203431 226482 110159223
Haemoptysis 101.01 62.46 8 203586 71346 110314359
Vertigo 100.50 62.46 19 203575 86851 110298854
Red blood cell count decreased 100.45 62.46 5 203589 65918 110319787
Haematocrit decreased 97.69 62.46 6 203588 66111 110319594
Breast cancer stage II 97.05 62.46 178 203416 27197 110358508
Respiratory distress 96.73 62.46 8 203586 68866 110316839
Unevaluable event 95.29 62.46 3 203591 59224 110326481
Illness 95.00 62.46 18 203576 82153 110303552
Blood pressure fluctuation 94.10 62.46 13 203581 74811 110310894
Systemic lupus erythematosus rash 93.84 62.46 54 203540 1981 110383724
Staphylococcal infection 93.25 62.46 10 203584 69934 110315771
Transaminases increased 92.92 62.46 6 203588 63384 110322321
Abdominal pain 92.63 62.46 559 203035 512430 109873275
Ulcer haemorrhage 91.96 62.46 156 203438 22415 110363290
Cardiac disorder 91.92 62.46 15 203579 76265 110309440
Lymphocyte count decreased 91.73 62.46 3 203591 57240 110328465
Swollen tongue 90.65 62.46 5 203589 60357 110325348
Adverse reaction 89.64 62.46 180 203414 29414 110356291
Off label use 89.28 62.46 2094 201500 1498091 108887614
Cystitis 89.17 62.46 9 203585 66027 110319678
Skin ulcer 87.73 62.46 8 203586 63637 110322068
Disturbance in attention 87.62 62.46 7 203587 61988 110323717
Anaphylactic reaction 87.21 62.46 51 203543 114249 110271456
Pallor 86.95 62.46 4 203590 56463 110329242
Septic shock 86.87 62.46 97 203497 157431 110228274
Dry eye 85.76 62.46 4 203590 55789 110329916
Leukocytosis 85.63 62.46 3 203591 53825 110331880
Diverticulitis 85.08 62.46 3 203591 53519 110332186
Paraesthesia 85.06 62.46 830 202764 275691 110110014
Red blood cell sedimentation rate increased 84.26 62.46 326 203268 77976 110307729
Tubulointerstitial nephritis 83.09 62.46 4 203590 54280 110331425
Angina pectoris 82.81 62.46 9 203585 62286 110323419
Drug tolerance decreased 82.81 62.46 167 203427 27373 110358332
Flatulence 82.63 62.46 3 203591 52146 110333559
Tinnitus 82.41 62.46 8 203586 60532 110325173
Cerebral infarction 82.08 62.46 3 203591 51835 110333870
Gastritis 82.05 62.46 4 203590 53695 110332010
Neoplasm progression 81.76 62.46 11 203583 64584 110321121
Arthralgia 81.70 62.46 1944 201650 777688 109608017
Spondylitis 79.13 62.46 101 203493 11237 110374468
Walking aid user 78.94 62.46 155 203439 24920 110360785
Drug eruption 78.89 62.46 5 203589 53654 110332051
Ventricular tachycardia 78.81 62.46 3 203591 50006 110335699
Depressed mood 77.82 62.46 10 203584 60799 110324906
Restlessness 77.74 62.46 7 203587 56252 110329453
Hepatotoxicity 77.45 62.46 12 203582 63388 110322317
Hypophagia 77.08 62.46 5 203589 52621 110333084
Urinary incontinence 76.28 62.46 3 203591 48584 110337121
Burning sensation 76.21 62.46 17 203577 69195 110316510
Disease recurrence 75.41 62.46 11 203583 60773 110324932
Eczema 75.22 62.46 20 203574 72273 110313432
Viral infection 75.10 62.46 6 203588 53133 110332572
Drug tolerance 74.80 62.46 120 203474 16465 110369240
Psychotic disorder 74.14 62.46 5 203589 50932 110334773
Haematoma 73.91 62.46 10 203584 58466 110327239
Ear infection 72.31 62.46 267 203327 62465 110323240
Product prescribing error 71.98 62.46 6 203588 51325 110334380
Obstructive airways disorder 71.95 62.46 3 203591 46146 110339559
Gamma-glutamyltransferase increased 71.80 62.46 13 203581 61296 110324409
Bacterial infection 71.75 62.46 3 203591 46033 110339672
Irritability 71.67 62.46 4 203590 47805 110337900
Blood potassium decreased 71.47 62.46 8 203586 54106 110331599
Condition aggravated 71.17 62.46 1813 201781 733023 109652682
Skin discolouration 70.84 62.46 5 203589 49041 110336664
Drug resistance 70.41 62.46 10 203584 56364 110329341
Neuralgia 69.86 62.46 5 203589 48473 110337232
Dysgeusia 69.78 62.46 21 203573 69964 110315741
Diabetes mellitus 69.45 62.46 49 203545 99332 110286373
Renal disorder 68.79 62.46 6 203588 49473 110336232
Respiratory tract infection 68.71 62.46 23 203571 71594 110314111
Bone pain 67.80 62.46 18 203576 65115 110320590
Multiple sclerosis relapse 67.44 62.46 7 203587 50233 110335472
Localised infection 66.44 62.46 3 203591 43045 110342660
Head injury 66.39 62.46 3 203591 43014 110342691
Circulatory collapse 66.35 62.46 3 203591 42990 110342715
Dysuria 65.90 62.46 15 203579 60216 110325489
Sinus tachycardia 65.85 62.46 4 203590 44489 110341216
Full blood count abnormal 65.39 62.46 12 203582 56040 110329665
Pollakiuria 65.33 62.46 4 203590 44191 110341514
Eye pain 64.69 62.46 8 203586 50091 110335614
Rash erythematous 64.60 62.46 35 203559 81797 110303908
Joint stiffness 64.39 62.46 270 203324 66973 110318732
Stevens-Johnson syndrome 64.36 62.46 6 203588 46895 110338810
Ulcer 63.44 62.46 4 203590 43112 110342593
Hepatocellular injury 63.21 62.46 9 203585 50633 110335072
Amnesia 62.92 62.46 370 203224 105038 110280667
Palmar-plantar erythrodysaesthesia syndrome 62.86 62.46 3 203591 41022 110344683
Coagulopathy 62.66 62.46 3 203591 40908 110344797
Nail operation 62.64 62.46 39 203555 1655 110384050
Skin lesion 62.55 62.46 10 203584 51621 110334084

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Otitis externa indication 3135009
Proctitis indication 3951002 DOID:3127
Keratitis indication 5888003 DOID:4677
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Cyclitis indication 17657000
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Chronic ulcerative proctitis indication 52231000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Ulcerative colitis indication 64766004 DOID:8577
Löffler's syndrome indication 64936001 DOID:9503
Iritis indication 65074000 DOID:1406
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Blepharoconjunctivitis indication 68659002 DOID:2456
Rheumatoid arthritis indication 69896004 DOID:7148
Hemorrhoids indication 70153002 DOID:9746
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Iridocyclitis indication 77971008
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Corneal abrasion indication 85848002
Infective otitis externa indication 86981007 DOID:9463
Infection by larvae of Trichinella spiralis indication 88264003
Acne vulgaris indication 88616000
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Corneal ulcer indication 91514001 DOID:8463
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Uveitis indication 128473001 DOID:13141
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Malignant otitis externa due to Pseudomonas aeruginosa indication 232230009
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Punctate keratopathy indication 246936005
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Infective blepharitis indication 312219000
Bacterial keratitis indication 314557000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Herpes zoster keratitis indication 397573005
Rosacea indication 398909004 DOID:8881
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Recurrent herpes simplex labialis indication 402892009
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Aphthous ulcer of mouth indication 426965005 DOID:9663
Allergic conjunctivitis indication 473460002 DOID:11204
Post traumatic osteoarthritis indication 699262001
Itching of ear indication 699392007
Inflammatory dermatosis indication 703938007
Post-Op Ocular Inflammation indication
Staphylococcus Aureus Otitis Externa indication
Mastoidectomy Cavity Infections indication
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Gingival Disorders indication
Synovitis due to Osteoarthritis indication
Minor Bacterial Skin Infections indication
Erythroblastic Anemia indication
Transfusion Reaction Urticaria indication
Superficial Ocular Infection indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Orthostatic hypotension off-label use 28651003
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Chronic purulent otitis media off-label use 38394007 DOID:14247
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Adrenoleukodystrophy off-label use 65389002 DOID:10588
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Pityriasis simplex off-label use 200767005
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Allergic otitis externa off-label use 405821001
Giant cell arteritis off-label use 414341000 DOID:13375
Itching of skin off-label use 418363000
Congenital Pituitary Hypoplasia off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Otitis Externa Eczema off-label use
Otitis Externa Seborrhea off-label use
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Herpes simplex keratitis contraindication 9389005
Bacterial septicemia contraindication 10001005 DOID:0040085
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Esophagitis contraindication 16761005 DOID:11963
Disease caused by parasite contraindication 17322007
Mood swings contraindication 18963009
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Cirrhosis of liver contraindication 19943007 DOID:5082
Herpes zoster auricularis contraindication 21954000 DOID:9210
Glaucoma contraindication 23986001 DOID:1686
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Shock contraindication 27942005
Herpes simplex dendritic keratitis contraindication 29943008
Fungal infection of eye contraindication 31194008
Bullous myringitis contraindication 33528003 DOID:13791
Viral disease contraindication 34014006 DOID:934
Severe myopia contraindication 34187009
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Hypercortisolism contraindication 47270006
Chronic heart failure contraindication 48447003
Tuberculosis of eye contraindication 49107007
Duodenal ulcer disease contraindication 51868009 DOID:1724
Perforation of tympanic membrane contraindication 60442001
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Third degree burn injury contraindication 80247002
Hyperglycemia contraindication 80394007 DOID:4195
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Krukenberg spindle contraindication 85430004
Bacterial infectious disease contraindication 87628006
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Disorder of mucous membrane contraindication 95351003
Bilateral cataracts contraindication 95722004
Hypoalbuminemia contraindication 119247004
Open wound contraindication 125643001
Eye infection contraindication 128351009
Seizure disorder contraindication 128613002
Bacterial infection of eye contraindication 128984004
Disorder of muscle contraindication 129565002 DOID:423
Tuberculosis of ear contraindication 186269001
Ophthalmic herpes simplex contraindication 186542001
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Disease of liver contraindication 235856003 DOID:409
Condyloma acuminatum contraindication 240542006 DOID:11168
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Peripheral edema contraindication 271809000
Injury of eye region contraindication 282752000
Varicella-zoster virus infection contraindication 309465005
Severe depression contraindication 310497006
Viral eye infection contraindication 312132001
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Skin irritation contraindication 367466007
Vaccinia keratitis contraindication 397552005
Gastric ulcer contraindication 397825006 DOID:10808
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Blister contraindication 417237009
Denuded skin contraindication 418242004
Exposure to varicella contraindication 444453009
Psychiatric Disturbance contraindication
Protozoal Infection contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.63 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Kd 6.02 WOMBAT-PK KEGG DRUG
Annexin A1 Cytosolic other WOMBAT-PK
Corticosteroid-binding globulin Secreted Ki 6.89 CHEMBL
Potassium voltage-gated channel subfamily A member 1 Ion channel EC50 4.48 CHEMBL
Sex hormone-binding globulin Secreted Kd 6.43 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.67 CHEMBL
Protein farnesyltransferase Enzyme IC50 4.85 CHEMBL

External reference:

IDSource
4017937 VUID
N0000146287 NUI
D00973 KEGG_DRUG
21655 RXNORM
C0056391 UMLSCUI
CHEBI:3897 CHEBI
CHEMBL1650 ChEMBL_ID
D003348 MESH_DESCRIPTOR_UI
DB01380 DRUGBANK_ID
5745 PUBCHEM_CID
883WKN7W8X UNII
4508 MMSL
51 MMSL
92 MMSL
002146 NDDF
127382005 SNOMEDCT_US
53-06-5 SECONDARY_CAS_RN
4017936 VANDF
883WKN7W8X INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cortisone Acetate HUMAN PRESCRIPTION DRUG LABEL 1 62135-173 TABLET 25 mg ORAL ANDA 10 sections