codeine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
725 76-57-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • codeine phosphate anhydrous
  • codeine anhydrous
  • codeine monohydrate
  • codeine
  • (-)-Codeine
  • morphine monomethyl ether
  • methylmorphine
  • codeine phosphate
  • codeine sulfate
  • codeine phosphate hydrate
  • codeine polistirex
  • N-Methylmorphine
An opioid analgesic related to MORPHINE but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.
  • Molecular weight: 299.37
  • Formula: C18H21NO3
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.93
  • ALOGS: -2.72
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 15998.34 37.26 3656 5611 64744 4564981
Toxicity to various agents 5144.50 37.26 1545 7722 70495 4559230
Drug abuse 3995.05 37.26 1039 8228 26908 4602817
Completed suicide 1520.51 37.26 548 8719 41897 4587828
Overdose 1050.13 37.26 422 8845 43137 4586588
Substance abuse 705.02 37.26 151 9116 1537 4628188
Intentional product misuse 585.39 37.26 219 9048 18274 4611451
Death 468.89 37.26 428 8839 197735 4431990
Rheumatoid arthritis 461.71 37.26 201 9066 24798 4604927
Granuloma skin 442.31 37.26 72 9195 111 4629614
Rash 419.02 37.26 312 8955 108076 4521649
Vomiting 413.16 37.26 322 8945 119377 4510348
Poisoning 411.71 37.26 127 9140 5847 4623878
Drug dependence 400.66 37.26 129 9138 6838 4622887
Blood parathyroid hormone decreased 397.55 37.26 74 9193 333 4629392
Nausea 385.79 37.26 366 8901 176967 4452758
Drug intolerance 359.93 37.26 162 9105 21584 4608141
Panniculitis 349.72 37.26 74 9193 704 4629021
Intentional overdose 337.63 37.26 155 9112 21611 4608114
Rheumatoid nodule 334.18 37.26 72 9195 752 4628973
Cardio-respiratory arrest 332.24 37.26 149 9118 19673 4610052
Drug ineffective 323.09 37.26 340 8927 185721 4444004
Respiratory depression 320.04 37.26 101 9166 5009 4624716
Respiratory arrest 318.08 37.26 129 9138 13291 4616434
Somnolence 291.80 37.26 177 9090 43483 4586242
Pain 281.62 37.26 232 9035 92638 4537087
Accidental overdose 272.06 37.26 104 9163 9151 4620574
Skin necrosis 256.36 37.26 70 9197 2075 4627650
Urticaria 250.45 37.26 155 9112 39418 4590307
Hypercalcaemia 249.70 37.26 83 9184 4855 4624870
Contraindicated product administered 246.26 37.26 83 9184 5068 4624657
Depressed level of consciousness 244.54 37.26 111 9156 15043 4614682
Hypersensitivity 234.29 37.26 147 9120 38274 4591451
Peripheral swelling 222.52 37.26 125 9142 26567 4603158
Loss of personal independence in daily activities 220.10 37.26 86 9181 8019 4621706
Drug eruption 218.72 37.26 81 9186 6522 4623203
Cardiac arrest 217.13 37.26 134 9133 33873 4595852
Coma 214.18 37.26 106 9161 17413 4612312
Basal cell carcinoma 211.85 37.26 76 9191 5588 4624137
Asphyxia 207.93 37.26 60 9207 2182 4627543
Anaphylactic reaction 203.15 37.26 103 9164 17807 4611918
Ulcer 201.34 37.26 64 9203 3243 4626482
Drug interaction 199.03 37.26 163 9104 64345 4565380
Constipation 197.89 37.26 137 9130 42017 4587708
Skin ulcer 196.82 37.26 77 9190 7201 4622524
Infusion related reaction 189.00 37.26 99 9168 18303 4611422
Contrast media allergy 185.30 37.26 39 9228 360 4629365
Malaise 183.32 37.26 180 9087 89977 4539748
Inflammation 181.59 37.26 80 9187 10091 4619634
Serotonin syndrome 173.61 37.26 70 9197 7082 4622643
Aspartate aminotransferase increased 171.22 37.26 103 9164 24835 4604890
Alanine aminotransferase increased 166.43 37.26 106 9161 28267 4601458
Rash pruritic 165.92 37.26 80 9187 12403 4617322
Poisoning deliberate 163.81 37.26 50 9217 2212 4627513
C-reactive protein increased 157.96 37.26 78 9189 12734 4616991
Treatment failure 156.42 37.26 80 9187 14067 4615658
Miosis 155.78 37.26 51 9216 2839 4626886
Pulmonary oedema 149.23 37.26 79 9188 14907 4614818
Pruritus 145.71 37.26 144 9123 72428 4557297
Drug tolerance decreased 134.29 37.26 31 9236 452 4629273
Dyspnoea 116.14 37.26 177 9090 138808 4490917
Confusional state 115.20 37.26 106 9161 48728 4580997
Gait disturbance 111.55 37.26 92 9175 36548 4593177
Tenosynovitis 111.37 37.26 30 9237 842 4628883
Dizziness 111.24 37.26 146 9121 99725 4530000
Blood pressure systolic increased 110.89 37.26 44 9223 4264 4625461
Arthralgia 110.68 37.26 132 9135 81862 4547863
Unresponsive to stimuli 108.42 37.26 56 9211 10037 4619688
Red blood cell sedimentation rate increased 106.84 37.26 40 9227 3313 4626412
Toxicologic test abnormal 106.80 37.26 24 9243 308 4629417
Tachycardia 104.96 37.26 83 9184 31062 4598663
Pulmonary congestion 103.80 37.26 41 9226 3925 4625800
Hypotension 101.79 37.26 115 9152 67285 4562440
Arteriosclerosis coronary artery 101.74 37.26 38 9229 3126 4626599
Hyperhidrosis 99.25 37.26 79 9188 29838 4599887
Hallucination 98.55 37.26 64 9203 17604 4612121
Joint swelling 98.39 37.26 72 9195 24006 4605719
Headache 95.37 37.26 151 9116 122222 4507503
Abdominal discomfort 94.19 37.26 75 9192 28333 4601392
Herpes zoster 92.27 37.26 59 9208 15804 4613921
Coma scale abnormal 89.74 37.26 29 9238 1547 4628178
Loss of consciousness 89.08 37.26 80 9187 35602 4594123
Abdominal pain upper 88.20 37.26 79 9188 35036 4594689
Dysarthria 87.32 37.26 52 9215 12280 4617445
Red blood cell sedimentation rate abnormal 86.23 37.26 23 9244 621 4629104
Bradypnoea 85.25 37.26 24 9243 796 4628929
Wrist surgery 84.48 37.26 18 9249 177 4629548
Cough 84.15 37.26 95 9172 55492 4574233
Abdominal pain 83.17 37.26 98 9169 59926 4569799
Accidental poisoning 83.16 37.26 20 9247 351 4629374
Renal papillary necrosis 81.22 37.26 16 9251 102 4629623
Delirium 80.60 37.26 50 9217 12702 4617023
Body temperature decreased 79.83 37.26 30 9237 2509 4627216
Upper respiratory tract infection 79.48 37.26 51 9216 13736 4615989
Pancreatic fibrosis 78.74 37.26 12 9255 8 4629717
Pneumonia aspiration 76.83 37.26 44 9223 9662 4620063
Musculoskeletal stiffness 76.02 37.26 56 9211 18846 4610879
Visceral congestion 74.31 37.26 16 9251 166 4629559
Therapeutic product effect decreased 74.17 37.26 55 9212 18698 4611027
Brain oedema 73.50 37.26 34 9233 4793 4624932
Agitation 72.01 37.26 60 9207 24140 4605585
Drug withdrawal syndrome 70.89 37.26 46 9221 12626 4617099
Hypertension 70.44 37.26 83 9184 50715 4579010
Arthropathy 70.28 37.26 43 9224 10655 4619070
C-reactive protein abnormal 69.88 37.26 22 9245 1078 4628647
Obliterative bronchiolitis 68.41 37.26 19 9248 599 4629126
Hepatic steatosis 68.15 37.26 35 9232 6193 4623532
Aggression 67.02 37.26 46 9221 13853 4615872
Pneumonia 66.77 37.26 117 9150 102698 4527027
Metabolic acidosis 66.76 37.26 44 9223 12396 4617329
Drug screen positive 65.44 37.26 25 9242 2187 4627538
Acute hepatic failure 65.39 37.26 33 9234 5629 4624096
Red blood cell sedimentation rate 63.33 37.26 11 9256 30 4629695
Distributive shock 63.32 37.26 15 9252 246 4629479
Insomnia 62.71 37.26 74 9193 45271 4584454
Accidental death 62.38 37.26 19 9248 833 4628892
Postmortem blood drug level abnormal 61.15 37.26 11 9256 39 4629686
Sleep disorder 60.83 37.26 40 9227 11223 4618502
Disturbance in attention 60.63 37.26 39 9228 10542 4619183
Suicide attempt 60.60 37.26 51 9216 20791 4608934
Limb operation 60.10 37.26 18 9249 745 4628980
Macrocytosis 59.67 37.26 16 9251 441 4629284
Aspiration 59.66 37.26 27 9240 3618 4626107
Syncope 59.08 37.26 62 9205 33333 4596392
Fall 58.87 37.26 95 9172 77951 4551774
Pancreatitis acute 57.43 37.26 35 9232 8608 4621117
Swelling 57.37 37.26 53 9214 24429 4605296
Psoriasis 56.77 37.26 58 9209 30226 4599499
Withdrawal syndrome 55.96 37.26 31 9236 6383 4623342
Exposure via ingestion 55.70 37.26 20 9247 1470 4628255
Snoring 55.13 37.26 18 9249 992 4628733
Respiratory rate decreased 54.35 37.26 18 9249 1037 4628688
Condition aggravated 54.01 37.26 78 9189 58093 4571632
Gallbladder cholesterolosis 53.68 37.26 12 9255 150 4629575
Finger deformity 53.67 37.26 18 9249 1079 4628646
Restless legs syndrome 53.62 37.26 25 9242 3586 4626139
Hyporesponsive to stimuli 53.59 37.26 14 9253 348 4629377
Acute kidney injury 53.47 37.26 86 9181 70345 4559380
Musculoskeletal pain 53.25 37.26 43 9224 16545 4613180
Pyrexia 52.30 37.26 108 9159 107036 4522689
Wrong patient received product 52.12 37.26 15 9252 539 4629186
Myocardial fibrosis 50.93 37.26 13 9254 294 4629431
Urinary retention 50.82 37.26 34 9233 9813 4619912
Medication error 49.76 37.26 39 9228 14377 4615348
Acidosis 48.78 37.26 23 9244 3383 4626342
Hepatotoxicity 48.56 37.26 31 9236 8268 4621457
Alcohol poisoning 48.39 37.26 16 9251 917 4628808
Patient uncooperative 47.37 37.26 9 9258 46 4629679
Fatigue 47.23 37.26 125 9142 145441 4484284
Enthesopathy 46.57 37.26 12 9255 282 4629443
Mobility decreased 46.18 37.26 36 9231 13169 4616556
Pallor 46.02 37.26 29 9238 7563 4622162
Drug withdrawal syndrome neonatal 45.44 37.26 18 9249 1734 4627991
Sciatica 45.05 37.26 21 9246 3010 4626715
Increased bronchial secretion 44.91 37.26 13 9254 477 4629248
Deformity 44.50 37.26 14 9253 684 4629041
Blood pressure diastolic decreased 43.93 37.26 18 9249 1893 4627832
Needle issue 43.82 37.26 18 9249 1905 4627820
Irritability 43.80 37.26 35 9232 13264 4616461
Suicidal ideation 43.49 37.26 43 9224 21540 4608185
White blood cell count abnormal 43.33 37.26 16 9251 1273 4628452
Foetal exposure during pregnancy 42.73 37.26 44 9223 23125 4606600
Stubbornness 41.77 37.26 8 9259 43 4629682
Feeling abnormal 41.60 37.26 54 9213 36351 4593374
Synovitis 41.59 37.26 21 9246 3584 4626141
Gangrene neonatal 40.00 37.26 6 9261 3 4629722
Intentional self-injury 39.32 37.26 26 9241 7357 4622368
Poor feeding infant 39.18 37.26 10 9257 226 4629499
Appetite disorder 39.10 37.26 14 9253 1020 4628705
Analgesic drug level above therapeutic 38.80 37.26 8 9259 66 4629659
Lower respiratory tract infection 38.77 37.26 29 9238 9974 4619751
Hand deformity 38.77 37.26 15 9252 1357 4628368
Liver function test abnormal 38.73 37.26 34 9233 14658 4615067
Nervous system disorder 37.57 37.26 24 9243 6407 4623318
Back pain 37.30 37.26 61 9206 50538 4579187
Angioedema 37.29 37.26 38 9229 19727 4609998

Pharmacologic Action:

SourceCodeDescription
ATC R05DA04 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Opium alkaloids and derivatives
ATC N02AA59 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA79 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AJ06 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ07 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ08 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ09 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:60606 opioid receptor agonist
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:35482 opioid analgesic
CHEBI has role CHEBI:88188 drug allergen
MeSH PA D000996 Antitussive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Sneezing indication 76067001
Common cold indication 82272006 DOID:10459
Headache disorder indication 230461009
Sore throat symptom indication 267102003
Influenza-like symptoms indication 315642008
Fever indication 386661006
Tension-type headache indication 398057008
Muscle Spasm with Pain indication
Diarrhea off-label use 62315008
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Sedation contraindication 72641008
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Acute intermittent porphyria contraindication 234422006 DOID:3890
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Poor metabolizer due to cytochrome p450 CYP2C19 variant contraindication 424500005
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Acute exacerbation of asthma contraindication 708038006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.38 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
54.3MG TUXARIN ER MAINPOINTE N206323 June 22, 2015 RX TABLET, EXTENDED RELEASE ORAL 9066942 Jan. 3, 2032 TREATMENT OF COUGH AND SYMPTOMS ASSOCIATED WITH UPPER RESPIRATORY ALLERGIES OR A COMMON COLD WITH CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE ORALLY ADMINISTERED EXTENDED RELEASE TABLETS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 6.14 CHEMBL CHEMBL
Kappa-type opioid receptor GPCR AGONIST Ki 4.59 CHEMBL
Delta-type opioid receptor GPCR AGONIST Ki 4.28 CHEMBL
Opioid receptor GPCR IC50 8 CHEMBL

External reference:

IDSource
D003061 MESH_DESCRIPTOR_UI
4017509 VUID
N0000145894 NUI
C0009214 UMLSCUI
D00195 KEGG_DRUG
11QV9BS0CB UNII
6854-40-6 SECONDARY_CAS_RN
85990009 SNOMEDCT_US
4017509 VANDF
001550 NDDF
2670 RXNORM
387494007 SNOMEDCT_US
4490 MMSL
d00012 MMSL
CHEBI:16714 CHEBI
CHEMBL485 ChEMBL_ID
CHEMBL284671 ChEMBL_ID
CHEMBL369475 ChEMBL_ID
DB00318 DRUGBANK_ID
CHEMBL1159819 ChEMBL_ID
1673 IUPHAR_LIGAND_ID
5284371 PUBCHEM_CID
CHEMBL1201099 ChEMBL_ID
CHEMBL1201463 ChEMBL_ID
CHEMBL4297091 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 30 mg ORAL NDA 20 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0243 TABLET 15 mg ORAL NDA 19 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0244 TABLET 30 mg ORAL NDA 19 sections
Codeine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0245 TABLET 60 mg ORAL NDA 19 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0050 TABLET 15 mg ORAL ANDA 14 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0150 TABLET 30 mg ORAL ANDA 14 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0093-0350 TABLET 60 mg ORAL ANDA 14 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0121-0504 SOLUTION 12 mg ORAL ANDA 15 sections
PROMETHAZINE HYDROCHLORIDE AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0121-0547 SYRUP 10 mg ORAL ANDA 15 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-0775 SOLUTION 10 mg ORAL OTC monograph final 9 sections
Acetaminophen and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 2 0121-1008 SOLUTION 30 mg ORAL ANDA 15 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-1550 SOLUTION 10 mg ORAL OTC monograph final 9 sections
Guaifenesin and Codeine Phosphate HUMAN OTC DRUG LABEL 2 0121-1775 SOLUTION 10 mg ORAL OTC monograph final 9 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0483 TABLET 15 mg ORAL ANDA 14 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0484 TABLET 30 mg ORAL ANDA 14 sections
ACETAMINOPHEN AND CODEINE PHOSPHATE HUMAN PRESCRIPTION DRUG LABEL 2 0406-0485 TABLET 60 mg ORAL ANDA 14 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0440-7026 TABLET 30 mg ORAL ANDA 15 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0440-7027 TABLET 60 mg ORAL ANDA 15 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0527-1312 CAPSULE 30 mg ORAL ANDA 12 sections
Codeine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0527-1698 TABLET 30 mg ORAL ANDA 19 sections
Codeine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0527-1699 TABLET 60 mg ORAL ANDA 19 sections
Codeine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0527-1727 TABLET 15 mg ORAL ANDA 19 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-2641 CAPSULE 30 mg ORAL ANDA 19 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-3220 CAPSULE 30 mg ORAL NDA AUTHORIZED GENERIC 19 sections
Butalbital, Aspirin, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0591-3546 CAPSULE 30 mg ORAL NDA AUTHORIZED GENERIC 20 sections
Promethazine with Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-1585 SOLUTION 10 mg ORAL ANDA 18 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2337 TABLET 15 mg ORAL ANDA 15 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2338 TABLET 30 mg ORAL ANDA 15 sections
Acetaminophen And Codeine HUMAN PRESCRIPTION DRUG LABEL 2 0603-2339 TABLET 60 mg ORAL ANDA 15 sections
Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0603-2553 CAPSULE 30 mg ORAL ANDA 20 sections