clonazepam Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 703 1622-61-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clonazepam
  • lonazep
  • klonopin
An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
  • Molecular weight: 315.71
  • Formula: C15H10ClN3O3
  • CLOGP: 2.38
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 87.28
  • ALOGS: -4.47
  • ROTB: 2

Drug dosage:

DoseUnitRoute
8 mg O
8 mg P

Approvals:

DateAgencyCompanyOrphan
June 4, 1975 FDA ROCHE

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 12308.92 36.28 2908 9481 39537 4587066
Toxicity to various agents 7768.56 36.28 2265 10124 69775 4556828
Respiratory arrest 3105.30 36.28 781 11608 12639 4613964
Drug abuse 3090.58 36.28 908 11481 27039 4599564
Cardiac arrest 2906.26 36.28 906 11483 33101 4593502
Cardio-respiratory arrest 2904.96 36.28 803 11586 19019 4607584
Overdose 1978.17 36.28 723 11666 42836 4583767
Death 1533.19 36.28 970 11419 197193 4429410
Intentional overdose 1268.11 36.28 436 11953 21330 4605273
Poisoning 1133.37 36.28 298 12091 5676 4620927
Suicide attempt 1099.94 36.28 388 12001 20454 4606149
Drug ineffective 1005.27 36.28 732 11657 185329 4441274
Intentional product misuse 985.83 36.28 347 12042 18146 4608457
Somnolence 979.87 36.28 438 11951 43222 4583381
Seizure 851.02 36.28 415 11974 49822 4576781
Anxiety 769.26 36.28 382 12007 47629 4578974
Depressed level of consciousness 644.76 36.28 241 12148 14913 4611690
Hypotension 603.11 36.28 365 12024 67035 4559568
Respiratory depression 590.72 36.28 173 12216 4937 4621666
Coma 586.29 36.28 234 12155 17285 4609318
Unresponsive to stimuli 581.60 36.28 201 12188 9892 4616711
Sedation 556.68 36.28 182 12207 7535 4619068
Drug interaction 532.60 36.28 332 12057 64176 4562427
Depression 450.88 36.28 268 12121 47465 4579138
Agitation 417.65 36.28 203 12186 23997 4602606
Insomnia 411.03 36.28 248 12141 45097 4581506
Confusional state 374.07 36.28 240 12149 48594 4578009
Neuroleptic malignant syndrome 368.17 36.28 124 12265 5623 4620980
Drug withdrawal syndrome 354.47 36.28 149 12240 12523 4614080
Loss of consciousness 351.45 36.28 206 12183 35476 4591127
Drug dependence 344.80 36.28 124 12265 6843 4619760
Tremor 335.31 36.28 201 12188 36058 4590545
Foetal exposure during pregnancy 330.87 36.28 171 12218 22998 4603605
Suicidal ideation 330.56 36.28 167 12222 21416 4605187
Aggression 328.23 36.28 145 12244 13754 4612849
Bradycardia 314.87 36.28 164 12225 22405 4604198
Exposure via ingestion 304.54 36.28 79 12310 1411 4625192
Electrocardiogram QT prolonged 293.17 36.28 138 12251 15157 4611446
Encephalopathy 277.79 36.28 117 12272 9870 4616733
Serotonin syndrome 275.77 36.28 106 12283 7046 4619557
Ataxia 270.90 36.28 97 12292 5280 4621323
Status epilepticus 270.81 36.28 95 12294 4868 4621735
Condition aggravated 268.67 36.28 210 12179 57961 4568642
Fall 265.51 36.28 236 12153 77810 4548793
Mental status changes 256.81 36.28 118 12271 12258 4614345
Fatigue 256.74 36.28 309 12080 145257 4481346
Psychotic disorder 256.03 36.28 113 12276 10682 4615921
Substance abuse 243.60 36.28 68 12321 1620 4624983
Disturbance in attention 235.67 36.28 106 12283 10475 4616128
Withdrawal syndrome 225.79 36.28 89 12300 6325 4620278
Lethargy 225.33 36.28 120 12269 17121 4609482
Dysarthria 220.16 36.28 106 12283 12226 4614377
Medication error 218.97 36.28 111 12278 14305 4612298
Hyperhidrosis 218.78 36.28 143 12246 29774 4596829
Accidental overdose 213.39 36.28 95 12294 9160 4617443
Dizziness 205.87 36.28 230 12159 99641 4526962
Tachycardia 201.58 36.28 138 12251 31007 4595596
Generalised tonic-clonic seizure 199.13 36.28 93 12296 10017 4616586
Exposure during pregnancy 194.47 36.28 138 12251 32833 4593770
Muscle rigidity 189.83 36.28 69 12320 3918 4622685
Disorientation 186.48 36.28 95 12294 12364 4614239
Hypoglycaemia 185.49 36.28 108 12281 18301 4608302
Speech disorder 184.29 36.28 92 12297 11470 4615133
Gait disturbance 181.43 36.28 138 12251 36502 4590101
Abnormal behaviour 180.65 36.28 92 12297 11964 4614639
Pulmonary oedema 178.21 36.28 98 12291 14888 4611715
Poisoning deliberate 177.78 36.28 57 12332 2205 4624398
Memory impairment 177.77 36.28 109 12280 20294 4606309
Dystonia 174.96 36.28 68 12321 4650 4621953
Intentional self-injury 174.08 36.28 77 12312 7306 4619297
Product complaint 164.70 36.28 75 12314 7619 4618984
Epilepsy 164.38 36.28 80 12309 9438 4617165
Acute respiratory distress syndrome 163.23 36.28 74 12315 7439 4619164
Hallucination 163.19 36.28 98 12291 17570 4609033
Feeling abnormal 160.44 36.28 128 12261 36277 4590326
Miosis 156.39 36.28 55 12334 2835 4623768
Respiratory failure 156.25 36.28 117 12272 30209 4596394
Parkinsonism 154.08 36.28 56 12333 3177 4623426
Pneumonia aspiration 151.04 36.28 76 12313 9630 4616973
Myoclonus 147.85 36.28 62 12327 5162 4621441
Restlessness 146.92 36.28 74 12315 9395 4617208
Headache 144.67 36.28 214 12175 122159 4504444
Hypotonia 143.92 36.28 55 12334 3591 4623012
Drug hypersensitivity 143.23 36.28 159 12230 68241 4558362
Myocardial depression 142.23 36.28 27 12362 96 4626507
Irritability 141.87 36.28 81 12308 13218 4613385
Mental disorder 141.23 36.28 67 12322 7467 4619136
Panic attack 141.15 36.28 63 12326 6104 4620499
Sopor 140.89 36.28 64 12325 6462 4620141
Product substitution issue 136.36 36.28 70 12319 9248 4617355
Electrocardiogram QRS complex prolonged 134.53 36.28 45 12344 1991 4624612
Delirium 134.23 36.28 77 12312 12675 4613928
Decorticate posture 133.58 36.28 23 12366 38 4626565
Weight increased 132.83 36.28 115 12274 36466 4590137
Catatonia 129.28 36.28 43 12346 1869 4624734
Drug screen positive 127.00 36.28 44 12345 2168 4624435
Cognitive disorder 125.84 36.28 69 12320 10412 4616191
Dyskinesia 125.18 36.28 66 12323 9209 4617394
Hypothermia 121.18 36.28 51 12338 4283 4622320
Rhabdomyolysis 120.18 36.28 84 12305 19474 4607129
Heart rate increased 119.48 36.28 82 12307 18460 4608143
Therapeutic response unexpected 118.96 36.28 58 12331 6864 4619739
Maternal exposure during pregnancy 115.86 36.28 78 12311 17015 4609588
Vomiting 115.84 36.28 191 12198 119508 4507095
Aspiration 115.82 36.28 47 12342 3598 4623005
Sleep disorder 113.19 36.28 66 12323 11197 4615406
Myocardial stunning 112.72 36.28 20 12369 43 4626560
Treatment noncompliance 111.76 36.28 67 12322 11960 4614643
Mydriasis 110.69 36.28 46 12343 3742 4622861
Multiple-drug resistance 110.65 36.28 30 12359 638 4625965
Balance disorder 109.75 36.28 74 12315 16182 4610421
Brain oedema 109.46 36.28 49 12340 4778 4621825
Nausea 106.86 36.28 231 12158 177102 4449501
Arrhythmia 106.52 36.28 68 12321 13564 4613039
Blood creatine phosphokinase increased 104.97 36.28 70 12319 15029 4611574
Amnesia 102.31 36.28 65 12324 12856 4613747
Coma scale abnormal 100.83 36.28 34 12355 1542 4625061
Salivary hypersecretion 100.68 36.28 40 12349 2897 4623706
Off label use 100.21 36.28 187 12202 128926 4497677
Sleep apnoea syndrome 99.76 36.28 45 12344 4466 4622137
Paranoia 99.02 36.28 45 12344 4544 4622059
Nervousness 98.25 36.28 53 12336 7739 4618864
Drug withdrawal syndrome neonatal 97.30 36.28 34 12355 1718 4624885
Respiratory rate decreased 97.10 36.28 30 12359 1025 4625578
Malaise 95.52 36.28 150 12239 90007 4536596
Cyanosis 94.67 36.28 48 12341 6174 4620429
Thinking abnormal 94.52 36.28 40 12349 3404 4623199
Dysphagia 92.09 36.28 80 12309 25451 4601152
Schizophrenia 90.78 36.28 40 12349 3755 4622848
Drug resistance 90.64 36.28 51 12338 8085 4618518
Delusion 89.46 36.28 42 12347 4568 4622035
Drug level increased 88.43 36.28 46 12343 6240 4620363
Hyperthermia 88.13 36.28 38 12351 3386 4623217
Disinhibition 87.66 36.28 25 12364 644 4625959
Personality disorder 87.58 36.28 25 12364 646 4625957
Asthenia 86.64 36.28 140 12249 86023 4540580
Drooling 84.24 36.28 30 12359 1603 4625000
Depressed mood 84.06 36.28 50 12339 8794 4617809
Hallucination, auditory 83.75 36.28 40 12349 4521 4622082
Akathisia 83.64 36.28 37 12352 3506 4623097
Blood pressure decreased 83.20 36.28 65 12324 17835 4608768
Cardiogenic shock 83.17 36.28 42 12347 5356 4621247
Product use in unapproved indication 82.80 36.28 75 12314 25198 4601405
Mania 82.77 36.28 41 12348 5017 4621586
Metabolic acidosis 82.45 36.28 56 12333 12384 4614219
Anger 81.50 36.28 42 12347 5587 4621016
Altered state of consciousness 80.84 36.28 47 12342 7924 4618679
Acute kidney injury 79.90 36.28 121 12268 70310 4556293
Feeling of despair 79.12 36.28 23 12366 635 4625968
Coordination abnormal 79.11 36.28 36 12353 3646 4622957
Weight decreased 78.64 36.28 105 12284 54359 4572244
Pneumonia 78.54 36.28 148 12241 102667 4523936
Asterixis 77.84 36.28 22 12367 548 4626055
Depressive symptom 77.65 36.28 25 12364 979 4625624
Hypomania 77.55 36.28 28 12361 1557 4625046
Intentional product use issue 77.52 36.28 44 12345 7091 4619512
Sinus tachycardia 77.47 36.28 42 12347 6192 4620411
Hyperreflexia 77.12 36.28 28 12361 1582 4625021
Ventricular hypokinesia 76.93 36.28 27 12362 1382 4625221
Psychomotor hyperactivity 74.67 36.28 36 12353 4153 4622450
Apathy 74.51 36.28 32 12357 2823 4623780
Vision blurred 74.26 36.28 70 12319 24733 4601870
Aphasia 73.61 36.28 46 12343 8834 4617769
Hypersomnia 73.56 36.28 36 12353 4291 4622312
Accidental death 73.26 36.28 23 12366 829 4625774
Premature baby 73.24 36.28 48 12341 10003 4616600
Alanine aminotransferase increased 71.74 36.28 73 12316 28300 4598303
Abortion spontaneous 71.34 36.28 54 12335 14138 4612465
Hyponatraemia 70.63 36.28 68 12321 24662 4601941
Respiratory rate increased 70.53 36.28 31 12358 2892 4623711
Electroencephalogram abnormal 70.19 36.28 26 12363 1555 4625048
Extrapyramidal disorder 69.43 36.28 37 12352 5269 4621334
Bradykinesia 68.95 36.28 24 12365 1198 4625405
Drug screen negative 68.75 36.28 16 12373 177 4626426
Developmental glaucoma 67.25 36.28 12 12377 27 4626576
Acute pulmonary oedema 66.65 36.28 29 12360 2640 4623963
Constipation 66.63 36.28 85 12304 42069 4584534
Incoherent 66.49 36.28 26 12363 1804 4624799
Hypoxia 66.11 36.28 50 12339 13071 4613532
Drug withdrawal convulsions 65.31 36.28 20 12369 663 4625940
Syncope 65.27 36.28 75 12314 33320 4593283
Urinary bladder rupture 64.90 36.28 13 12376 65 4626538
Illness anxiety disorder 64.68 36.28 14 12375 108 4626495
Pulmonary congestion 64.45 36.28 32 12357 3934 4622669
Tachypnoea 63.57 36.28 34 12355 4877 4621726
Ventricular septal defect 63.23 36.28 27 12362 2348 4624255
Pyrexia 62.53 36.28 138 12251 107006 4519597
Respiratory acidosis 62.34 36.28 24 12365 1597 4625006
Stevens-Johnson syndrome 62.32 36.28 41 12348 8598 4618005
Multiple organ dysfunction syndrome 62.09 36.28 56 12333 18700 4607903
Dehydration 61.73 36.28 82 12307 42208 4584395
Derealisation 61.52 36.28 17 12372 389 4626214
Body temperature decreased 61.50 36.28 27 12362 2512 4624091
Atonic seizures 61.47 36.28 15 12374 206 4626397
Restless legs syndrome 61.26 36.28 30 12359 3581 4623022
Aspartate aminotransferase increased 60.93 36.28 63 12326 24875 4601728
Blood pressure increased 60.69 36.28 68 12321 29392 4597211
Wrong product administered 60.47 36.28 29 12360 3306 4623297
Hallucination, visual 60.37 36.28 35 12354 5867 4620736
Therapeutic product effect decreased 60.13 36.28 55 12334 18698 4607905
Loss of personal independence in daily activities 59.77 36.28 39 12350 8066 4618537
Paradoxical drug reaction 59.66 36.28 21 12368 1084 4625519
Nightmare 59.45 36.28 37 12352 7053 4619550
Ejection fraction decreased 59.42 36.28 34 12355 5562 4621041
Dysmetria 59.34 36.28 14 12375 165 4626438
Palpitations 59.32 36.28 62 12327 24784 4601819
Sinus bradycardia 58.81 36.28 31 12358 4318 4622285
Postictal paralysis 58.35 36.28 12 12377 70 4626533
Persecutory delusion 57.87 36.28 20 12369 977 4625626
Tardive dyskinesia 57.82 36.28 28 12361 3261 4623342
Fear 57.29 36.28 30 12359 4122 4622481
Intellectual disability 56.74 36.28 16 12373 395 4626208
Dyspnoea 56.68 36.28 156 12233 138829 4487774
Pregnancy 56.67 36.28 39 12350 8805 4617798
Incorrect dose administered 56.66 36.28 54 12335 19331 4607272
Pupil fixed 56.54 36.28 19 12370 852 4625751
Mental impairment 55.95 36.28 31 12358 4767 4621836
Abdominal pain 55.51 36.28 94 12295 59930 4566673
Electrocardiogram QRS complex shortened 55.43 36.28 13 12376 149 4626454
Product use issue 55.39 36.28 60 12329 24976 4601627
Purpura senile 55.30 36.28 10 12379 25 4626578
Muscle twitching 55.16 36.28 31 12358 4900 4621703
Depersonalisation/derealisation disorder 54.89 36.28 16 12373 446 4626157
Obsessive-compulsive disorder 54.59 36.28 22 12367 1653 4624950
Hepatic enzyme increased 54.27 36.28 51 12338 17940 4608663
Shock 54.05 36.28 38 12351 8878 4617725
Decreased appetite 53.05 36.28 89 12300 56308 4570295
Hypertension 52.98 36.28 84 12305 50714 4575889
Myoclonic epilepsy 52.96 36.28 16 12373 506 4626097
Hepatitis 51.73 36.28 42 12347 12163 4614440
Incontinence 51.37 36.28 24 12365 2580 4624023
Upper airway obstruction 51.27 36.28 14 12375 306 4626297
Drug level above therapeutic 51.15 36.28 19 12370 1145 4625458
Respiratory distress 50.84 36.28 40 12349 11076 4615527
Poor feeding infant 50.57 36.28 13 12376 223 4626380
Ammonia increased 50.41 36.28 21 12368 1717 4624886
Sexual abuse 50.14 36.28 11 12378 91 4626512
Maternal drugs affecting foetus 50.06 36.28 27 12362 3938 4622665
Snoring 50.00 36.28 18 12371 992 4625611
Therapeutic response decreased 49.51 36.28 44 12345 14407 4612196
Hyperammonaemia 49.50 36.28 22 12367 2107 4624496
Hyperprolactinaemia 48.99 36.28 18 12371 1052 4625551
No adverse event 48.83 36.28 53 12336 22110 4604493
Pupillary reflex impaired 48.45 36.28 17 12372 869 4625734
Developmental delay 48.33 36.28 18 12371 1093 4625510
Stress 48.11 36.28 37 12352 9911 4616692
Acidosis 48.11 36.28 25 12364 3381 4623222
Hallucinations, mixed 47.59 36.28 18 12371 1141 4625462
Muscle spasms 47.51 36.28 66 12323 35424 4591179
Dysphoria 47.17 36.28 23 12366 2718 4623885
Drug abuser 47.13 36.28 23 12366 2724 4623879
Hypoxic-ischaemic encephalopathy 46.73 36.28 20 12369 1749 4624854
Caesarean section 46.30 36.28 28 12361 5070 4621533
Blood sodium decreased 45.81 36.28 29 12360 5693 4620910
Panic disorder 45.65 36.28 16 12373 815 4625788
Obstructive airways disorder 45.14 36.28 22 12367 2598 4624005
Cough 44.84 36.28 82 12307 55505 4571098
Tarsal tunnel syndrome 44.76 36.28 9 12380 46 4626557
Hypophagia 44.60 36.28 32 12357 7716 4618887
Drug tolerance 44.51 36.28 16 12373 878 4625725
Oxygen saturation decreased 44.45 36.28 41 12348 14080 4612523
Libido decreased 44.41 36.28 20 12369 1976 4624627
Polydactyly 44.26 36.28 14 12375 517 4626086
Urinary retention 44.10 36.28 35 12354 9812 4616791
Atrioventricular block first degree 43.94 36.28 20 12369 2025 4624578
Apnoea 43.75 36.28 23 12366 3185 4623418
Pain 43.67 36.28 110 12279 92760 4533843
Crying 43.42 36.28 29 12360 6234 4620369
Toxic encephalopathy 43.40 36.28 19 12370 1755 4624848
Device interaction 43.18 36.28 10 12379 108 4626495
Ventricular arrhythmia 42.99 36.28 18 12371 1490 4625113
Drug reaction with eosinophilia and systemic symptoms 42.80 36.28 37 12352 11676 4614927
Nervous system disorder 42.72 36.28 29 12360 6402 4620201
Blood bicarbonate decreased 42.58 36.28 16 12373 996 4625607
Helplessness 42.47 36.28 9 12380 62 4626541
Depression suicidal 42.42 36.28 14 12375 593 4626010
Feeling jittery 42.15 36.28 22 12367 3002 4623601
Emotional disorder 41.96 36.28 23 12366 3462 4623141
Blood pH decreased 41.94 36.28 16 12373 1038 4625565
Toxicologic test abnormal 41.67 36.28 12 12377 320 4626283
Inappropriate antidiuretic hormone secretion 41.53 36.28 25 12364 4489 4622114
Psychomotor retardation 41.14 36.28 16 12373 1094 4625509
Cogwheel rigidity 41.05 36.28 13 12376 482 4626121
Epileptic encephalopathy 41.00 36.28 8 12381 34 4626569
Treatment failure 40.56 36.28 39 12350 14108 4612495
Middle insomnia 40.40 36.28 20 12369 2442 4624161
Brain death 40.29 36.28 16 12373 1156 4625447
Skin abrasion 40.26 36.28 19 12370 2089 4624514
Movement disorder 40.22 36.28 25 12364 4754 4621849
Drug use disorder 39.53 36.28 15 12374 959 4625644
Nodal rhythm 39.30 36.28 14 12375 748 4625855
Dry mouth 39.24 36.28 37 12352 13064 4613539
Alcohol abuse 39.19 36.28 15 12374 982 4625621
Coma blister 39.15 36.28 8 12381 45 4626558
Hepatic failure 39.12 36.28 37 12352 13112 4613491
Bradyphrenia 39.08 36.28 18 12371 1873 4624730
Eosinophilic myocarditis 39.07 36.28 11 12378 270 4626333
Blood lactic acid increased 38.62 36.28 18 12371 1924 4624679
Soft tissue haemorrhage 38.15 36.28 9 12380 106 4626497
Compartment syndrome 38.13 36.28 15 12374 1057 4625546
Antipsychotic drug level increased 37.83 36.28 16 12373 1358 4625245
Impaired driving ability 37.63 36.28 17 12372 1691 4624912
Pulse absent 37.62 36.28 18 12371 2041 4624562
Anticonvulsant drug level above therapeutic 37.59 36.28 11 12378 311 4626292
Hepatic necrosis 37.51 36.28 18 12371 2054 4624549
Incorrect route of product administration 37.45 36.28 34 12355 11439 4615164
Product quality issue 37.34 36.28 44 12345 20055 4606548
Maternal exposure during breast feeding 37.20 36.28 16 12373 1416 4625187
Muscle spasticity 37.14 36.28 21 12368 3357 4623246
Alcohol use 36.92 36.28 16 12373 1442 4625161
Cardiotoxicity 36.86 36.28 20 12369 2950 4623653
Self esteem decreased 36.81 36.28 11 12378 335 4626268
Clonus 36.76 36.28 15 12374 1163 4625440
Somatic symptom disorder 36.67 36.28 12 12377 495 4626108
Autonomic nervous system imbalance 36.61 36.28 14 12375 914 4625689
Alcohol poisoning 36.54 36.28 14 12375 919 4625684
Muscular weakness 36.46 36.28 50 12339 26500 4600103
Areflexia 36.45 36.28 15 12374 1189 4625414
Tension 36.37 36.28 14 12375 931 4625672
Bipolar disorder 36.28 36.28 18 12371 2208 4624395

Pharmacologic Action:

SourceCodeDescription
ATC N03AE01 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Benzodiazepine derivatives
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50268 GABA modulator
CHEBI has role CHEBI:35474 anxiolytic drug
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D018377 Neurotransmitter Agents
FDA EPC N0000175694 Benzodiazepine
FDA CS M0002356 Benzodiazepines

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myoclonic seizure indication 37356005
Atonic seizure indication 42365007
Absence seizure indication 79631006
Lennox-Gastaut syndrome indication 230418006
Panic disorder indication 371631005 DOID:594
Akathisia off-label use 285145004
Manic Bipolar Disorder Adjunct Treatment off-label use
Suicidal thoughts contraindication 6471006
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.65 acidic
pKa2 1.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.07 WOMBAT-PK CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL
GABA-A receptor; anion channel Ion channel IC50 8.77 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 9.07 CHEMBL

External reference:

IDSource
D002998 MESH_DESCRIPTOR_UI
4017791 VUID
N0000146152 NUI
C0009011 UMLSCUI
D00280 KEGG_DRUG
5PE9FDE8GB UNII
2765 INN_ID
69708003 SNOMEDCT_US
4017791 VANDF
001635 NDDF
2598 RXNORM
377 MMSL
d00197 MMSL
387383007 SNOMEDCT_US
4477 MMSL
CHEMBL452 ChEMBL_ID
DB01068 DRUGBANK_ID
CHEBI:3756 CHEBI
6963 IUPHAR_LIGAND_ID
2802 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0058 TABLET 1 mg ORAL NDA 15 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0068 TABLET 0.50 mg ORAL NDA 15 sections
Klonopin HUMAN PRESCRIPTION DRUG LABEL 1 0004-0098 TABLET 2 mg ORAL NDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0832 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3212 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0093-3213 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0063 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0064 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0185-0065 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3003 TABLET 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3004 TABLET 1 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-3005 TABLET 2 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1910 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1912 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-1914 TABLET 2 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0094 TABLET, ORALLY DISINTEGRATING 0.13 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0095 TABLET, ORALLY DISINTEGRATING 0.25 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0096 TABLET, ORALLY DISINTEGRATING 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0097 TABLET, ORALLY DISINTEGRATING 1 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0555-0098 TABLET, ORALLY DISINTEGRATING 2 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-7796 TABLET 0.50 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8001 TABLET 0.50 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8002 TABLET 1 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8048 TABLET 2 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8227 TABLET 0.50 mg ORAL ANDA 15 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8234 TABLET 0.50 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8235 TABLET 1 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0615-8236 TABLET 2 mg ORAL ANDA 13 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5567 TABLET 1 mg ORAL ANDA 14 sections
Clonazepam HUMAN PRESCRIPTION DRUG LABEL 1 0781-5569 TABLET 2 mg ORAL ANDA 14 sections