clioquinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 681 130-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clioquinol
  • chloroiodoquin
  • chloroiodoquine
  • cliquinol
  • iodochlorhydroxyquin
A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
  • Molecular weight: 305.50
  • Formula: C9H5ClINO
  • CLOGP: 3.73
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 33.12
  • ALOGS: -3.06
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D08AH30 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Quinoline derivatives
ATC D09AA10 DERMATOLOGICALS
MEDICATED DRESSINGS
MEDICATED DRESSINGS
Medicated dressings with antiinfectives
ATC G01AC02 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Quinoline derivatives
ATC P01AA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Hydroxyquinoline derivatives
ATC P01AA52 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Hydroxyquinoline derivatives
ATC S02AA05 SENSORY ORGANS
OTOLOGICALS
ANTIINFECTIVES
Antiinfectives
FDA CS M0000728 Allergens
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA EPC N0000185508 Standardized Chemical Allergen
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35718 antifungal agents
CHEBI has role CHEBI:35820 antiprotozoal drugs
CHEBI has role CHEBI:38161 Chelating agent
CHEBI has role CHEBI:166831 copper chelator

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Tinea corporis indication 84849002
Tinea cruris indication 399029005
Open wound contraindication 125643001
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Diarrhea Indication

🐶 Veterinary products

ProductApplicantIngredients
Rheaform Bolus Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.63 acidic
pKa2 2.39 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amyloid beta A4 protein Unclassified IC50 4 CHEMBL
Catechol O-methyltransferase Enzyme IC50 5.32 CHEMBL
Botulinum neurotoxin type A Enzyme IC50 4.69 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.63 CHEMBL
Spike glycoprotein Glycoprotein IC50 5.25 CHEMBL

External reference:

IDSource
4018572 VUID
N0000146888 NUI
D03538 KEGG_DRUG
5942 RXNORM
4018572 VANDF
C0021978 UMLSCUI
CHEBI:74460 CHEBI
CQL PDB_CHEM_ID
CHEMBL497 ChEMBL_ID
DB04815 DRUGBANK_ID
D007464 MESH_DESCRIPTOR_UI
2788 PUBCHEM_CID
2116 INN_ID
7BHQ856EJ5 UNII
4470 MMSL
6683 MMSL
002874 NDDF
387291001 SNOMEDCT_US
52896000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DERMOSCRIBE ICHYBUM HUMAN OTC DRUG LABEL 2 69683-101 CREAM 1 g TOPICAL OTC monograph not final 9 sections
DERMOSCRIBE ICHYBUM HUMAN OTC DRUG LABEL 2 69683-101 CREAM 1 g TOPICAL OTC monograph not final 9 sections
DERMOSCRIBE DIAPER HUMAN OTC DRUG LABEL 2 69683-102 OINTMENT 1 g TOPICAL OTC monograph not final 9 sections
DERMOSCRIBE DIAPER HUMAN OTC DRUG LABEL 2 69683-102 OINTMENT 1 g TOPICAL OTC monograph not final 9 sections