acetyldigoxin indications/contra

Stem definitionDrug idCAS RN
68 5355-48-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetyldigoxin
  • novodigal
  • beta-Acetyldigoxin
  • beta acetyldigoxin
Alpha- or beta-acetyl derivatives of DIGOXIN or lanatoside C from Digitalis lanata. They are better absorbed and longer acting than digoxin and are used in congestive heart failure.
  • Molecular weight: 822.99
  • Formula: C43H66O15
  • CLOGP: 1.99
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 5
  • TPSA: 209.13
  • ALOGS: -4.08
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.50 mg O

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Stevens-Johnson syndrome 64.36 57.27 10 15 6762 3379072

Pharmacologic Action:

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SourceCodeDescription
ATC C01AA02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides
ATC C01AA52 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC GLYCOSIDES
Digitalis glycosides

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
N0000168451 NUI
C0001050 UMLSCUI
N0000168451 NDFRT
199 RXNORM
007426 NDDF
CHEMBL2074725 ChEMBL_ID
10350481 PUBCHEM_CID
D000113 MESH_DESCRIPTOR_UI
CHEBI:135892 CHEBI

Pharmaceutical products:

None