acetyldigitoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 67 | 1111-39-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Cardioactive derivatives of lanatoside A or of DIGITOXIN. They are used for fast digitalization in congestive heart failure.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 70 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 24, 1975 | FDA | NOVARTIS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01AA01 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Digitalis glycosides |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:23924 | enzyme inhibitors |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:38147 | cardiotonic drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Congestive heart failure | indication | 42343007 | DOID:6000 |
| Atrial fibrillation | indication | 49436004 | DOID:0060224 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium/potassium-transporting ATPase | Transporter | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D06881 | KEGG_DRUG |
| 132871 | RXNORM |
| C0520442 | UMLSCUI |
| CHEBI:53773 | CHEBI |
| CHEMBL3545057 | ChEMBL_ID |
| D000112 | MESH_DESCRIPTOR_UI |
| DB00511 | DRUGBANK_ID |
| 6794 | IUPHAR_LIGAND_ID |
| 792 | INN_ID |
| 0ZV4Q4L2FU | UNII |
| 5284512 | PUBCHEM_CID |
| 7834009 | SNOMEDCT_US |
| 000596 | NDDF |
Pharmaceutical products:
None