ciprofibrate Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists 658 52214-84-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ciprofibrate
  • lipanor
  • oroxadin
Ciprofibrate is a new derivative of phenoxyisobutyric acid which has a marked hypolipidaemic action. It reduces both LDL and VLDL and hence the levels of triglyceride and cholesterol associated with these lipoprotein fractions. It also increases levels of HDL cholesterol.
  • Molecular weight: 289.15
  • Formula: C13H14Cl2O3
  • CLOGP: 3.18
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -4.57
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
June 18, 2009 UK Medicines and Healthcare Products Regulatory Agency (MHRA) Winthrop Pharmaceuticals UK Limited

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AB08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
Fibrates
CHEBI has role CHEBI:35679 antilipemic drug
MeSH PA D000963 Antimetabolites
MeSH PA D002273 Carcinogens
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
MeSH PA D009676 Noxae
MeSH PA D020025 Peroxisome Proliferators

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor AGONIST EC50 6.05 CHEMBL SCIENTIFIC LITERATURE

External reference:

IDSource
C0055775 UMLSCUI
D03521 KEGG_DRUG
320016006 SNOMEDCT_US
21149 RXNORM
395957009 SNOMEDCT_US
004087 NDDF
CHEBI:50867 CHEBI
CHEMBL557555 ChEMBL_ID
F8252JGO9S UNII
4057 INN_ID
DB09064 DRUGBANK_ID
3438 IUPHAR_LIGAND_ID
2763 PUBCHEM_CID
C019304 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None