cinoxacin indications/contra

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 657 28657-80-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cinoxacin
  • cinobac
  • cinobactin
Synthetic antimicrobial related to OXOLINIC ACID and NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
  • Molecular weight: 262.22
  • Formula: C12H10N2O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 88.43
  • ALOGS: -2.44
  • ROTB: 2

Drug dosage:

DoseUnitRoute
1 g O

Approvals:

DateAgencyCompanyOrphan
June 13, 1980 FDA LILLY

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01MB06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Other quinolones
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:35441 antiinfective agent
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Urinary tract infectious disease indication 68566005

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 acidic
pKa2 3.27 Basic
pKa3 0.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme IC50 4.08 WOMBAT-PK
DNA gyrase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4019087 VUID
N0000147347 NUI
C0008806 UMLSCUI
D00872 KEGG_DRUG
DB00827 DRUGBANK_ID
2762 PUBCHEM_CID
4019087 VANDF
N0000007043 NDFRT
N0000147347 NDFRT
002865 NDDF
109 MMSL
2550 RXNORM
387549004 SNOMEDCT_US
96081007 SNOMEDCT_US
4450 MMSL
d01129 MMSL
CHEMBL1208 ChEMBL_ID
CHEBI:3716 CHEBI
D002937 MESH_DESCRIPTOR_UI
LMK22VUH23 UNII
3513 INN_ID

Pharmaceutical products:

None