cinnoxicam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, isoxicam derivatives 655 87234-24-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sinartrol
  • cinnoxicam
  • piroxicam cinnamate
  • Molecular weight: 461.49
  • Formula: C24H19N3O5S
  • CLOGP: 4.42
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 105.67
  • ALOGS: -5.32
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:35544 cyclooxygenase inhibitors
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:50630 COX-1 inhibitor
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.9 acidic
pKa2 4.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05512 KEGG_DRUG
33787 RXNORM
4018626 VANDF
C0071149 UMLSCUI
CHEBI:135749 CHEBI
CHEBI:8249 CHEBI
DB15883 DRUGBANK_ID
C057291 MESH_SUPPLEMENTAL_RECORD_UI
6436090 PUBCHEM_CID
1529 MMSL
5308 MMSL
d00343 MMSL
002389 NDDF
004364 NDDF
27754002 SNOMEDCT_US
387153005 SNOMEDCT_US
C0031990 UMLSCUI
CHEMBL2106889 ChEMBL_ID
DB00554 DRUGBANK_ID
3713 INN_ID
D010894 MESH_DESCRIPTOR_UI
54676228 PUBCHEM_CID
7E8Q32N75N UNII

Pharmaceutical products:

None