acetylcarnitine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 64 | 3040-38-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 32 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BX12 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics |
| FDA CS | M0003493 | Carnitine |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018977 | Micronutrients |
| MeSH PA | D018697 | Nootropic Agents |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| FDA EPC | N0000175903 | Carnitine Analog |
| CHEBI has role | CHEBI:27314 | water-soluble vitamins |
| CHEBI has role | CHEBI:35679 | antilipemic drugs |
| CHEBI has role | CHEBI:50733 | Dietary Supplement |
| CHEBI has role | CHEBI:66980 | intelligence enhancer |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Senile dementia | indication | 15662003 | |
| Alzheimer's disease | indication | 26929004 | DOID:10652 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.41 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4029065 | VUID |
| N0000179824 | NUI |
| 193 | RXNORM |
| C0001040 | UMLSCUI |
| CHEBI:73024 | CHEBI |
| CHEBI:16347 | CHEBI |
| CHEMBL1358846 | ChEMBL_ID |
| CHEMBL1697733 | ChEMBL_ID |
| DB08842 | DRUGBANK_ID |
| D000108 | MESH_DESCRIPTOR_UI |
| 7045767 | PUBCHEM_CID |
| 6DH1W9VH8Q | UNII |
| DB00583 | DRUGBANK_ID |
| 329486002 | SNOMEDCT_US |
| 372601001 | SNOMEDCT_US |
| C0087163 | UMLSCUI |
| 4018934 | VANDF |
| 4020870 | VANDF |
| 4029065 | VANDF |
| 6098 | INN_ID |
| 10917 | PUBCHEM_CID |
| 10540 | MMSL |
| 147388 | MMSL |
| 4970 | MMSL |
| d00491 | MMSL |
| D002331 | MESH_DESCRIPTOR_UI |
| 003576 | NDDF |
| 006988 | NDDF |
Pharmaceutical products:
None