cicloprolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 637 94651-09-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cicloprolol
  • cicloprolol hydrochloride
  • cycloprolol
  • cicloprolol HCl
  • Molecular weight: 323.43
  • Formula: C18H29NO4
  • CLOGP: 2.39
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -3.69
  • ROTB: 12

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR Ki 6.20 WOMBAT-PK
Beta-1 adrenergic receptor GPCR Ki 8 WOMBAT-PK

External reference:

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IDSource
552 IUPHAR_LIGAND_ID
D03490 KEGG_DRUG
1K2ACH4U3R UNII
5250 INN_ID
63659-12-1 SECONDARY_CAS_RN
146294 PUBCHEM_CID
C053708 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2105976 ChEMBL_ID
CHEMBL2110772 ChEMBL_ID
CHEBI:135377 CHEBI

Pharmaceutical products:

None